The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.
Alzheimer’s disease: risk factors and potentially protective measures
Open accessAbstract
Alzheimer's disease (AD) is the most common type of dementia and typically manifests through a progressive loss of episodic memory and cognitive function, subsequently causing language and visuospatial skills deficiencies, which are often accompanied by behavioral disorders such as apathy, aggressiveness and depression. The presence of extracellular plaques of insoluble β-amyloid peptide (Aβ) and neurofibrillary tangles (NFT) containing hyperphosphorylated tau protein (P-tau) in the neuronal cytoplasm is a remarkable pathophysiological cause in patients' brains. Approximately 70% of the risk of developing AD can be attributed to genetics. However, acquired factors such as cerebrovascular diseases, diabetes, hypertension, obesity and dyslipidemia increase the risk of AD development. The aim of the present minireview was to summarize the pathophysiological mechanism and the main risk factors for AD. As a complement, some protective factors associated with a lower risk of disease incidence, such as cognitive reserve, physical activity and diet will also be addressed.
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Cites
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Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy
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Neurotrophins: Roles in Neuronal Development and Function
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Clinical and biomarker changes in dominantly inherited Alzheimer's disease
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TREM2 Variants in Alzheimer's Disease
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Neurovascular pathways to neurodegeneration in Alzheimer’s disease and other disorders
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Variant of TREM2 Associated with the Risk of Alzheimer's Disease
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Cited by
Zhang, J., Zhang, Y., Wang, J., Xia, Y., Zhang, J., & Chen, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01911-3 · Cited by 1,138
“The objective of this study is to con fi rm the ef fi cacy of masitinib ( 28 ) as an adjunct therapy to cholinesterase inhibitors and/or memantine ( 7 ) in improving cognitive and functional abilities in patients with mild to moderate AD.”
BackgroundAlzheimer's Disease: Treatment Strategies and Their Limitations.
Passeri, E., Elkhoury, K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate, C., Yen, F. T., & Arab-Tehrany, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232213954 · Cited by 689
“Other factors are involved, including nutrition and other environmental parameters that can protect cardiovascular pathologies, thereby reducing AD risk [87].”
BackgroundZhong, Q., Xiao, X., Qiu, Y., Xu, Z., Chen, C., Chong, B., Zhao, X., Hai, S., Li, S., An, Z., et al. (2023) · MedComm · doi:10.1002/mco2.261 · Cited by 442
Alzheimer’s Disease: An Updated Overview of Its Genetics
Andrade-Guerrero, J., Santiago-Balmaseda, A., Jeronimo-Aguilar, P., Vargas-Rodríguez, I., Cadena-Suárez, A. R., Sánchez-Garibay, C., Pozo-Molina, G., Méndez-Catalá, C. F., Cardenas-Aguayo, M.-D.-C., Diaz-Cintra, S., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043754 · Cited by 336
Challenges and hopes for Alzheimer’s disease
Tatulian, S. A. (2022) · Drug Discovery Today · doi:10.1016/j.drudis.2022.01.016 · Cited by 291
Metadata
- Authors
- Silva, M. V. F., Loures, C. D. M. G., Alves, L. C. V., de Souza, L. C., Borges, K. B. G., & Carvalho, M. D. G.
- Venue
- Journal of Biomedical Science
- Published
- 2019-05-09
- Volume
- 26
- Issue
- 1
- Pages
- 33-33
- ISSN
- 1021-7770 (ISSN-L)
- 1423-0127
- OpenAlex
- W2947686928
- Cited by
- 937
- References
- 142
- FWCI
- 46.74
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Silva, M. V. F., Loures, C. D. M. G., Alves, L. C. V., de Souza, L. C., Borges, K. B. G., & Carvalho, M. D. G. (2019). Alzheimer’s disease: risk factors and potentially protective measures. Journal of Biomedical Science. https://doi.org/10.1186/s12929-019-0524-y
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