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Cited by 152Asthma and respiratory diseasesOccupational exposure and asthmaChronic Obstructive Pulmonary Disease (COPD) Research

The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.

Determinants and impact of suboptimal asthma control in Europe: The INTERNATIONAL CROSS-SECTIONAL AND LONGITUDINAL ASSESSMENT ON ASTHMA CONTROL (LIAISON) study

Open access
on behalf of the LIAISON Study Group, Braido, Fulvio, Brusselle, Guy, Guastalla, Daniele, Ingrassia, Eleonora, Nicolini, Gabriele, Price, David, Roche, Nicolas, Soriano, Joan B., Worth, Heinrich·2016·Respiratory Research
DOI 10.1186/s12931-016-0374-zPMC PMC4894377
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Abstract

BACKGROUND: According to the Global Initiative of Asthma, the aim of asthma treatment is to gain and maintain control. In the INTERNATIONAL CROSS-SECTIONAL AND LONGITUDINAL ASSESSMENT ON ASTHMA CONTROL (LIAISON) study, we evaluated the level of asthma control and quality of life (QoL), as well as their determinants and impact in a population consulting specialist settings. METHODS: LIAISON is a prospective, multicentre, observational study with a cross-sectional and a 12-month longitudinal phase. Adults with an asthma diagnosis since at least 6 months, receiving the same asthma treatment in the 4 weeks before enrolment were included. Asthma control was assessed with the 6-item Asthma Control Questionnaire (ACQ) and QoL with the MiniAsthma Quality of Life Questionnaire (MiniAQLQ). RESULTS: Overall, 8111 asthmatic patients were enrolled in 12 European countries. Asthma control was suboptimal in 56.5 % of patients and it was associated with poorer asthma-related QoL, higher risk of exacerbations and greater consumption of healthcare resources. Variables associated with suboptimal control were age, gender, obesity, smoking and comorbidities. Major determinants of poor asthma control were seasonal worsening and persisting exposure to allergens/irritants/triggers, followed by treatment-related issues. CONCLUSIONS: The cross-sectional phase results confirm that suboptimal control is frequent and has a high individual and economic impact. TRIAL REGISTRATION: The clinicaltrials.gov identifier is NCT01567280 .

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Fig. 1 Asthma Control Index among countries of the LIAISON study. The index was computed as the ratio of patients with controlled asthma (6-item ACQ < 0.75) to patients with not well-controlled asthma (6-item ACQ ≤ 0.75). Asthma Control Index >1: greater proportion of patients with controlled asthma. Asthma Control Index <1: greater proportion of patients with not well-controlled asthma
Fig. 1 Asthma Control Index among countries of the LIAISON study. The index was computed as the ratio of patients with controlled asthma (6-item ACQ < 0.75) to patients with not well-controlled asthma (6-item ACQ ≤ 0.75). Asthma Control Index >1: greater proportion of patients with controlled asthma. Asthma Control Index <1: greater proportion of patients with not well-controlled asthmaCC BY · PubMed Central
Fig. 2 Mean overall score of the Mini Asthma Quality of Life Questionnaire by asthma control level. *Overall p-value < .001
Fig. 2 Mean overall score of the Mini Asthma Quality of Life Questionnaire by asthma control level. *Overall p-value < .001CC BY · PubMed Central

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  1. Bettoncelli G, Magnoni MS, Fassari C, Tosatto R, Di Blasi P, De Marco R, Novelletto BF, Mazzaglia GP, Caramori G, Studio P.A.C.I.S. (Point out Asthma Control Italian Survey). Il controllo dell’asma in Italia misurato con ACT (Asthma Control Test). Società Italiana di Medicina Generale. 2006;6:10–7.

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Authors
on behalf of the LIAISON Study Group, Braido, F., Brusselle, G., Guastalla, D., Ingrassia, E., Nicolini, G., Price, D., Roche, N., Soriano, J. B., & Worth, H.
Affiliations
  • Ospedale Policlinico San Martino (IT)
  • Ghent University Hospital (BE)
  • Chiesi (Italy) (IT)
  • University of Aberdeen (GB)
  • Hospital Universitario de La Princesa (ES)
Corresponding author
Ingrassia, Eleonora
ORCID
Venue
Respiratory Research
Publisher
Springer Science and Business Media LLC
Published
2016-05-14
Volume
17
Issue
1
Pages
51-51
ISSN
  • 1465-9921 (ISSN-L)
  • 1465-993X
DOI
10.1186/s12931-016-0374-z
PMC
PMC4894377
OpenAlex
W2360510406
Cited by
152
References
22
Citations by year
2026: 8 · 2025: 15 · 2024: 11 · 2023: 13 · 2022: 19 · 2021: 21 · 2020: 19 · 2019: 21 · 2018: 14 · 2017: 9 · 2016: 2
FWCI
12.35
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Respiratory Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (publishedVersion, cc-by)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion)
  • Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (acceptedVersion, other-oa)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion, cc-by)
  • Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
  • Biblos-e Archivo (Universidad Autónoma de Madrid) (submittedVersion, public-domain)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
  • RePub (Erasmus University Rotterdam) (submittedVersion, other-oa)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
  • Hispana (submittedVersion)
  • CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion, other-oa)
  • RePub (Erasmus University Rotterdam) (submittedVersion)
Funders
Chiesi Farmaceutici
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Keywords
asthma control, asthma quality of life, asthma exacerbations, healthcare resource utilization, Asthma Control Questionnaire, smoking, obesity, comorbidities
MeSH terms
Adult, Age Factors, Aged, Asthma, Cross-Sectional Studies, Europe, Female, Health Resources, Humans, Longitudinal Studies, Lung, Male, Middle Aged, Obesity, Prospective Studies, Quality of Life, Surveys and Questionnaires, Risk Factors, Seasons, Sex Factors, Smoking, Time Factors, Comorbidity, Drug Costs, Treatment Outcome, Disease Progression, Anti-Asthmatic Agents, Medication Adherence

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