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Comprehensive elaboration of glycemic variability in diabetic macrovascular and microvascular complications
Open accessAbstract
Diabetes mellitus is the major risk factor for the development of macrovascular and microvascular complications. It is increasingly recognized that glycemic variability (GV), referring to oscillations in blood glucose levels and representing either short-term or long-term GV, is involved in the pathogenesis of diabetic complications and has emerged as a possible independent risk factor for them. In this review, we summarize the metrics and measurement of GV in clinical practice, as well as comprehensively elaborate the role and related mechanisms of GV in diabetic macrovascular and microvascular complications, aiming to provide the mechanism-based therapeutic strategies for clinicians to manage diabetes mellitus.
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“This glycaemic variability, is associated with both microvascular and macrovascular complications, with reduced quality of life, and increasing in the psychological burden of diabetes management [98–100].”
From Diabetic gastroparesis: pathophysiology and impact on insulin timing choices (2026) · cites this paper as [100]
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Long-term glycemic variability and the risk of heart failure: a meta-analysis
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Metadata
- Authors
- Sun, B., Luo, Z., & Zhou, J.
- Affiliations
- Central South University (CN)
- First Affiliated Hospital of University of South China (CN)
- Corresponding author
- Luo, Zhiying
- Zhou, Jiecan
- Venue
- Cardiovascular Diabetology
- Published
- 2021-01-07
- Volume
- 20
- Issue
- 1
- Pages
- 9-9
- ISSN
- 1475-2840 (ISSN-L)
- PMC
- PMC7792304
- OpenAlex
- W3121117564
- Cited by
- 168
- References
- 122
- Citations by year
- 2026: 26 · 2025: 27 · 2024: 40 · 2023: 33 · 2022: 33 · 2021: 9
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cardiovascular Diabetology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Natural Science Foundation of Hunan Province (2020JJ5513)
- Scientific Research Fund Project of Hunan Provincial Health Commission (20201973)
- Scientific Research Fund of Hunan Provincial Education Department (19A418)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- glycemic variability, diabetes mellitus, macrovascular complications, microvascular complications, risk factors, treatment options
- MeSH terms
- Glycemic Control, Animals, Blood Glucose, Diabetes Mellitus, Diabetic Angiopathies, Glycated Hemoglobin, Humans, Hypoglycemic Agents, Risk Factors, Biomarkers, Treatment Outcome, Risk Assessment
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