The DOI matches its Crossref record; 81 of the 81 references it cites were found in a registry or an index.
Bacillus subtilis: a universal cell factory for industry, agriculture, biomaterials and medicine
Open accessAbstract
Due to its clear inherited backgrounds as well as simple and diverse genetic manipulation systems, Bacillus subtilis is the key Gram-positive model bacterium for studies on physiology and metabolism. Furthermore, due to its highly efficient protein secretion system and adaptable metabolism, it has been widely used as a cell factory for microbial production of chemicals, enzymes, and antimicrobial materials for industry, agriculture, and medicine. In this mini-review, we first summarize the basic genetic manipulation tools and expression systems for this bacterium, including traditional methods and novel engineering systems. Secondly, we briefly introduce its applications in the production of chemicals and enzymes, and summarize its advantages, mainly focusing on some noteworthy products and recent progress in the engineering of B. subtilis. Finally, this review also covers applications such as microbial additives and antimicrobials, as well as biofilm systems and spore formation. We hope to provide an overview for novice researchers in this area, offering them a better understanding of B. subtilis and its applications.
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Cites
Spores of Bacillus subtilis: their resistance to and killing by radiation, heat and chemicals
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Bacillus subtilis antibiotics: structures, syntheses and specific functions
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Ecology and genomics of Bacillus subtilis
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Riboflavin: The Health Benefits of a Forgotten Natural Vitamin
Suwannasom, N., Kao, I., Pruß, A., Georgieva, R., & Bäumler, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030950 · Cited by 444
Bacillus subtilis: from soil bacterium to super-secreting cell factory
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Bacillus strains as human probiotics: characterization, safety, microbiome, and probiotic carrier
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Cited by
Li, Z., Zheng, M., Zheng, J., & Gänzle, M. G. (2023) · Current Opinion in Food Science · doi:10.1016/j.cofs.2023.101007 · Cited by 128
Improving Surfactin Production in Bacillus subtilis 168 by Metabolic Engineering
Guo, Z., Sun, J., Ma, Q., Li, M., Dou, Y., Yang, S., & Gao, X. (2024) · Microorganisms · doi:10.3390/microorganisms12050998 · Cited by 34
Treinen, C., Magosch, O., Hoffmann, M., Klausmann, P., Würtz, B., Pfannstiel, J., Morabbi Heravi, K., Lilge, L., Hausmann, R., & Henkel, M. (2021) · AMB Express · doi:10.1186/s13568-021-01306-5 · Cited by 14
Grigs, O., Didrihsone, E., & Bolmanis, E. (2023) · Fermentation · doi:10.3390/fermentation9040390 · Cited by 7
Ngearnpat, N., Chunhachart, O., Kotabin, N., & Issakul, K. (2023) · Journal of Ecological Engineering · doi:10.12911/22998993/172054 · Cited by 4
Metadata
- Authors
- Su, Y., Liu, C., Fang, H., & Zhang, D.
- Venue
- Microbial Cell Factories
- Published
- 2020-09-03
- Volume
- 19
- Issue
- 1
- Pages
- 173-173
- ISSN
- 1475-2859 (ISSN-L)
- OpenAlex
- W3081744280
- Cited by
- 531
- References
- 81
- FWCI
- 13.00
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
