The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Unravelling the structural and mechanistic basis of CRISPR–Cas systems
Open accessAbstract
Bacteria and archaea have evolved sophisticated adaptive immune systems, known as CRISPR–Cas (clustered regularly interspaced short palindromic repeats–CRISPR-associated proteins) systems, which target and inactivate invading viruses and plasmids. Immunity is acquired by integrating short fragments of foreign DNA into CRISPR loci, and following transcription and processing of these loci, the CRISPR RNAs (crRNAs) guide the Cas proteins to complementary invading nucleic acid, which results in target interference. In this Review, we summarize the recent structural and biochemical insights that have been gained for the three major types of CRISPR–Cas systems, which together provide a detailed molecular understanding of the unique and conserved mechanisms of RNA-guided adaptive immunity in bacteria and archaea.
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Cites
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
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CRISPR RNA Maturation by Trans-Encoded Small RNA and Host Factor RNase III
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RNA-guided editing of bacterial genomes using CRISPR-Cas systems
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Crystal structure of Cas9 in complex with guide RNA and target DNA
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Self-citationStructures of Cas9 endonucleases reveal RNA-mediated conformational activation
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CRISPR-mediated adaptive immune systems in bacteria and archaea
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Cited by
The new frontier of genome engineering with CRISPR-Cas9
Doudna, J. A., & Charpentier, E. (2014) · Science · doi:10.1126/science.1258096 · Cited by 7,062
An updated evolutionary classification of CRISPR–Cas systems
Makarova, K. S., Wolf, Y. I., Alkhnbashi, O. S., Costa, F., Shah, S. A., Saunders, S. J., Barrangou, R., Brouns, S. J. J., Charpentier, E., Haft, D. H., et al. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3569 · Cited by 2,480
Self-citationCRISPR–Cas9 Structures and Mechanisms
Jiang, F., & Doudna, J. A. (2017) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-062215-010822 · Cited by 2,029
RNA virus interference via CRISPR/Cas13a system in plants
Aman, R., Ali, Z., Butt, H., Mahas, A., Aljedaani, F., Khan, M. Z., Ding, S., & Mahfouz, M. (2018) · Genome Biology · doi:10.1186/s13059-017-1381-1 · Cited by 1,497
Diversity, classification and evolution of CRISPR-Cas systems
Koonin, E. V., Makarova, K. S., & Zhang, F. (2017) · Current Opinion in Microbiology · doi:10.1016/j.mib.2017.05.008 · Cited by 1,423
Metadata
- Authors
- van der Oost, J., Westra, E. R., Jackson, R. N., & Wiedenheft, B.
- Venue
- Nature Reviews Microbiology
- Published
- 2014-06-09
- Volume
- 12
- Issue
- 7
- Pages
- 479-492
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W2153552126
- Cited by
- 714
- References
- 9
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- green
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- van der Oost, J., Westra, E. R., Jackson, R. N., & Wiedenheft, B. (2014). Unravelling the structural and mechanistic basis of CRISPR–Cas systems. Nature Reviews Microbiology. https://doi.org/10.1038/nrmicro3279
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