Cited by 106MicroRNA in disease regulationCancer-related molecular mechanisms researchCancer-related Molecular Pathways

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MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

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Faramin Lashkarian, Mahboobeh, Hashemipour, Nasrin, Niaraki, Negin, Soghala, Shahrad, Moradi, Ali, Sarhangi, Sareh, Hatami, Mahsa, Aghaei-Zarch, Fatemehsadat, Khosravifar, Mina, Mohammadzadeh, Alireza, Najafi, Sajad, Majidpoor, Jamal, Farnia, Poopak, Aghaei-Zarch, Seyed Mohsen·2023·Cancer Cell International

DOI 10.1186/s12935-023-02868-zPMC PMC9940444

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Abstract

MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptionally and interact with mRNA-coding genes. MiRNAs play vital roles in many biological functions, and abnormal miRNA expression has been linked to various illnesses, including cancer. Among the miRNAs, miR-122, miR-206, miR-21, miR-210, miR-223, and miR-424 have been extensively studied in various cancers. Although research in miRNAs has grown considerably over the last decade, much is yet to be discovered, especially regarding their role in cancer therapies. Several kinds of cancer have been linked to dysregulation and abnormal expression of miR-122, indicating that miR-122 may serve as a diagnostic and/or prognostic biomarker for human cancer. Consequently, in this review literature, miR-122 has been analyzed in numerous cancer types to sort out the function of cancer cells miR-122 and enhance patient response to standard therapy.

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Fig. 1 Schematic representation of miR-122 biosynthesis and its role in cancer progressionCC BY · PubMed Central

Fig. 2 miR-122 target different mRNA in different tissuesCC BY · PubMed Central

Fig. 3 An overview of the regulatory role of miR-122 in cancer therapy resistance in different cancers. Recent studies have shown that miR-122 by targeting different proteins plays a major role in resistance to different cancer therapiesCC BY · PubMed Central

Fig. 4 An overview of the regulatory role of miR-122 in cancer stem cells in different cancers. Recent studies demonstrated that miR-122 by targeting various proteins plays a crucial in the stemness of cancer stem cellsCC BY · PubMed Central

Fig. 5 miR-122 replacement therapy via various tools to combat cancerCC BY · PubMed Central

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Long Noncoding RNA UCA1 Targets miR-122 to Promote Proliferation, Migration, and Invasion of Glioma Cells
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RETRACTED: MiR-211 plays a dual role in cancer development: From tumor suppressor to tumor enhancer
Shirvani, H., Ghanavi, J., Aliabadi, A., Mousavinasab, F., Talebi, M., Majidpoor, J., Najafi, S., Miryounesi, S. M., & Zarch, S. M. A. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110504 · Cited by 48
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RETRACTED: MiR-122 Induces Radiosensitization in Non-Small Cell Lung Cancer Cell Line
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miR-122 Inhibits Hepatocarcinoma Cell Progression by Targeting LMNB2
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MicroRNA-122 inhibits proliferation and invasion in gastric cancer by targeting CREB1.
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RETRACTED: MiR-122 Promotes the Development of Colon Cancer by Targeting ALDOA In Vitro
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Shirvani H, Ghanavi J, Aliabadi A, Mousavinasab F, Talebi M, Majidpour J, et al. MiR-211 play dual regulatory role in cancer development: from tumor suppressor to tumor enhancer. Cell Signal. 2022;101:110504. · DOI

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Additional file 8 of LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability
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Additional file 3 of LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability
Han, L., Jiang, Y., Shi, M., Gan, L., Wu, Z., Xue, M., Zhu, Y., Xiong, C., Wang, T., Lin, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26643397
Additional file 1 of Profiling the metabolic disorder and detection of colorectal cancer based on targeted amino acids metabolomics
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Additional file 5 of LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability
Han, L., Jiang, Y., Shi, M., Gan, L., Wu, Z., Xue, M., Zhu, Y., Xiong, C., Wang, T., Lin, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26643403
Additional file 1 of LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability
Han, L., Jiang, Y., Shi, M., Gan, L., Wu, Z., Xue, M., Zhu, Y., Xiong, C., Wang, T., Lin, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26643391
Additional file 2 of LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability
Han, L., Jiang, Y., Shi, M., Gan, L., Wu, Z., Xue, M., Zhu, Y., Xiong, C., Wang, T., Lin, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26643394
Additional file 6 of LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability
Han, L., Jiang, Y., Shi, M., Gan, L., Wu, Z., Xue, M., Zhu, Y., Xiong, C., Wang, T., Lin, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26643406
Additional file 2 of Rutaecarpine induces the differentiation of triple-negative breast cancer cells through inhibiting fumarate hydratase
Lei, J., Pan, Y., Gao, R., He, B., Wang, Z., Lei, X., Zhang, Z., Yang, N., & Yan, M. (2023) · Figshare · doi:10.6084/m9.figshare.23983353
Additional file 1 of Cancer-associated fibroblasts drive colorectal cancer cell progression through exosomal miR-20a-5p-mediated targeting of PTEN and stimulating interleukin-6 production
Shahpar, M. G., Pakravan, K., Razmara, E., Amooie, F., Mahmoudian, M., Heshmati, M., & Babashah, S. (2024) · Figshare · doi:10.6084/m9.figshare.25522689
Additional file 4 of LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability
Han, L., Jiang, Y., Shi, M., Gan, L., Wu, Z., Xue, M., Zhu, Y., Xiong, C., Wang, T., Lin, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26643400
Additional file 7 of LIPH contributes to glycolytic phenotype in pancreatic ductal adenocarcinoma by activating LPA/LPAR axis and maintaining ALDOA stability
Han, L., Jiang, Y., Shi, M., Gan, L., Wu, Z., Xue, M., Zhu, Y., Xiong, C., Wang, T., Lin, X., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26643409

Authors: Faramin Lashkarian, M., Hashemipour, N., Niaraki, N., Soghala, S., Moradi, A., Sarhangi, S., Hatami, M., Aghaei-Zarch, F., Khosravifar, M., Mohammadzadeh, A., Najafi, S., Majidpoor, J., Farnia, P., & Aghaei-Zarch, S. M.
Affiliations: Yazd University (IR)
Shahid Beheshti University (IR)
Islamic Azad University, Tehran (IR)
Kerman University of Medical Sciences (IR)
University of Pennsylvania (US)
Gonabad University of Medical Sciences (IR)
Masih Daneshvari Hospital (IR)
Corresponding author: Aghaei-Zarch, Fatemehsadat
Najafi, Sajad
Majidpoor, Jamal
Farnia, Poopak
ORCID: Hashemipour, Nasrin
Moradi, Ali
Hatami, Mahsa
Khosravifar, Mina
Mohammadzadeh, Alireza
Najafi, Sajad
Majidpoor, Jamal
Farnia, Poopak
Venue: Cancer Cell International
Publisher: Springer Science and Business Media LLC
Published: 2023-02-20
Volume: 23
Issue: 1
Pages: 29-29
ISSN: 1475-2867 (ISSN-L)
DOI: 10.1186/s12935-023-02868-z
PMC: PMC9940444
OpenAlex: W4321371253
Cited by: 105
References: 121
Citations by year: 2026: 9 · 2025: 36 · 2024: 30 · 2023: 30
FWCI: 3.35
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Cancer Cell International (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: miR-122, microRNA, cancer, post-transcriptional regulation, microRNA dysregulation, diagnostic biomarkers, prognostic factors, cancer therapy response, miR-21, miR-210, miR-223, miR-424, miR-206

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MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

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