The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
MicroRNA-122 in human cancers: from mechanistic to clinical perspectives
Open accessAbstract
MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptionally and interact with mRNA-coding genes. MiRNAs play vital roles in many biological functions, and abnormal miRNA expression has been linked to various illnesses, including cancer. Among the miRNAs, miR-122, miR-206, miR-21, miR-210, miR-223, and miR-424 have been extensively studied in various cancers. Although research in miRNAs has grown considerably over the last decade, much is yet to be discovered, especially regarding their role in cancer therapies. Several kinds of cancer have been linked to dysregulation and abnormal expression of miR-122, indicating that miR-122 may serve as a diagnostic and/or prognostic biomarker for human cancer. Consequently, in this review literature, miR-122 has been analyzed in numerous cancer types to sort out the function of cancer cells miR-122 and enhance patient response to standard therapy.
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“From this analysis, we selected the three abundant miRNAs-hsa-miR-122-5p, hsa-let-7a-5p, and hsa-miR26a-5p-based on their complementary and comprehensive coverage of almost all the critical genes associated with the MAPK signaling pathway 27-33 as analyzed using miRTarBase version 8.0 and TarBase v8.0 integrated within miRNet (Figure S1).”
From rAAV-mediated Multi-miRNA Delivery Targeting MAPK Pathway Suppresses Laser-induced Choroidal Neovascularization in Mice (2026) · cites this paper as [33]
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7 retracted
Sun, Y., Jin, J., Mi, W., Hao-Wu, Zhang, S., Meng, Q., & Zhang, S. (2017) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504017x14934860122864 · Cited by 60
RetractedRETRACTED: MiR-211 plays a dual role in cancer development: From tumor suppressor to tumor enhancer
Shirvani, H., Ghanavi, J., Aliabadi, A., Mousavinasab, F., Talebi, M., Majidpoor, J., Najafi, S., Miryounesi, S. M., & Zarch, S. M. A. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110504 · Cited by 48
Self-citationRetractedRETRACTED: MiR-122 Induces Radiosensitization in Non-Small Cell Lung Cancer Cell Line
Ma, D., Jia, H., Qin, M., Dai, W., Wang, T., Liang, E., Dong, G., Wang, Z., Zhang, Z., & Feng, F. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160922137 · Cited by 47
RetractedmiR-122 Inhibits Hepatocarcinoma Cell Progression by Targeting LMNB2
Li, X.-N., Yang, H., & Yang, T. (2020) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504019x15615433287579 · Cited by 34
RetractedMicroRNA-122 inhibits proliferation and invasion in gastric cancer by targeting CREB1.
Rao, M., Zhu, Y., Zhou, Y., Cong, X., & Li, F. (2017) · Europe PMC (PubMed Central) · Cited by 33
RetractedRETRACTED: MiR-122 Promotes the Development of Colon Cancer by Targeting ALDOA In Vitro
Li, H., Zhang, X., Jin, Z. Y., Yin, T., Duan, C., Sun, J., Xiong, R., & Li, Z. (2019) · Technology in Cancer Research & Treatment · doi:10.1177/1533033819871300 · Cited by 29
RetractedRETRACTED: Non-coding RNA in SARS-CoV-2: Progress toward therapeutic significance
Shirvani, H., Jafari, H., Moravveji, S. S., Faranghizadeh, F. A., Talebi, M., Ghanavi, J., Esfandi, F., Najafi, S., Moghadam, M. N., Farnia, P., et al. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.09.105 · Cited by 20
Self-citationRetractedA microRNA expression signature of human solid tumors defines cancer gene targets
Volinia, S., Calin, G. A., Liu, C.-G., Ambs, S., Cimmino, A., Petrocca, F., Visone, R., Iorio, M., Roldo, C., Ferracin, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510565103 · Cited by 5,697
Yang (2021) · doi:10.1038/s41598-020-79139-8 · Cited by 5,035
The role of MicroRNAs in human cancer
Peng, Y., & Croce, C. M. (2016) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2015.4 · Cited by 2,566
Research works printed but not linked: 1
- Shirvani H, Ghanavi J, Aliabadi A, Mousavinasab F, Talebi M, Majidpour J, et al. MiR-211 play dual regulatory role in cancer development: from tumor suppressor to tumor enhancer. Cell Signal. 2022;101:110504. · DOI
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RETRACTED: microRNA-382 as a tumor suppressor? Roles in tumorigenesis and clinical significance
Fattahi, M., Shahrabi, S., Saadatpour, F., Rezaee, D., Beyglu, Z., Delavari, S., Amrolahi, A., Ahmadi, S., Bagheri‐Mohammadi, S., Noori, E., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125863 · Cited by 75
Self-citationRetractedRezaee, D., Saadatpour, F., Akbari, N., Zoghi, A., Najafi, S., Beyranvand, P., Rarani, F. Z., Rashidi, M. A., Bagheri‐Mohammadi, S., & Bakhtiari, M. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102090 · Cited by 76
Self-citationAn interplay between non-coding RNAs and gut microbiota in human health
Fardi, F., Khasraghi, L. B., Shahbakhti, N., Naseriyan, A. S., Najafi, S., Sanaaee, S., Alipourfard, I., Zamany, M., Karamipour, S., Jahani, M., et al. (2023) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2023.110739 · Cited by 60
Self-citationNon-coding RNAs/DNMT3B axis in human cancers: from pathogenesis to clinical significance
Huang, C., Azizi, P., Vazirzadeh, M., Zarch, S. M. A., Aghaei-Zarch, F., Ghanavi, J., & Farnia, P. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04510-y · Cited by 56
Self-citationZaki, M. B., Abulsoud, A. I., Elshaer, S. S., Fathi, D., Abdelmaksoud, N. M., El‐Mahdy, H. A., Ismail, A., Elsakka, E. G. E., Sallam, A.-A. M., & Doghish, A. S. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154437 · Cited by 53
Metadata
- Authors
- Faramin Lashkarian, M., Hashemipour, N., Niaraki, N., Soghala, S., Moradi, A., Sarhangi, S., Hatami, M., Aghaei-Zarch, F., Khosravifar, M., Mohammadzadeh, A., Najafi, S., Majidpoor, J., Farnia, P., & Aghaei-Zarch, S. M.
- Affiliations
- Yazd University (IR)
- Shahid Beheshti University (IR)
- Islamic Azad University, Tehran (IR)
- Kerman University of Medical Sciences (IR)
- University of Pennsylvania (US)
- Gonabad University of Medical Sciences (IR)
- Masih Daneshvari Hospital (IR)
- Corresponding author
- Aghaei-Zarch, Fatemehsadat
- Najafi, Sajad
- Majidpoor, Jamal
- Farnia, Poopak
- ORCID
- Venue
- Cancer Cell International
- Published
- 2023-02-20
- Volume
- 23
- Issue
- 1
- Pages
- 29-29
- ISSN
- 1475-2867 (ISSN-L)
- PMC
- PMC9940444
- OpenAlex
- W4321371253
- Cited by
- 105
- References
- 121
- Citations by year
- 2026: 9 · 2025: 36 · 2024: 30 · 2023: 30
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cancer Cell International (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- miR-122, microRNA, cancer, post-transcriptional regulation, microRNA dysregulation, diagnostic biomarkers, prognostic factors, cancer therapy response, miR-21, miR-210, miR-223, miR-424, miR-206
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