The role of early detection and treatment in malaria elimination
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Falciparum malaria persists in hard-to-reach areas or demographic groups that are missed by conventional healthcare systems but could be reached by trained community members in a malaria post (MP). The main focus of a MP is to provide uninterrupted and rapid access to rapid diagnostic tests (RDTs) and artemisinin-based combination therapy (ACT) too all inhabitants of a village. RDTs allow trained community members to perform malaria diagnosis accurately and prescribe appropriate treatment, reducing as much as possible any delay between the onset of fever and treatment. Early treatment with ACT and with a low-dose of primaquine prevents further transmission from human to mosquito. A functioning MP represents an essential component of any malaria elimination strategy. Implementing large-scale, high-coverage, community-based early diagnosis and treatment through MPs requires few technological innovations but relies on a very well structured organization able to train, supervise and supply MPs, to monitor activity and to perform strict malaria surveillance.
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The early detection and prompt treatment approach with combination therapy artesunate/mefloquine for P. falciparum and chloroquine for non-falciparum infections, introduced in 1995, has been very effective and consistent with previous publications on malaria control in the Thailand-Myanmar border camps and for migrant populations.
“The early detection and prompt treatment approach with combination therapy artesunate/mefloquine for P. falciparum and chloroquine for non-falciparum (principally P. vivax) infections, introduced in 1995, has been very effective and consistent with previous publications on malaria control in the Thailand-Myanmar border camps and for migrant populations (Landier et al., 2016; Carrara et al., 2013;”
From Mother, child and adolescent health outcomes in two long-term refugee camp settings at the Thai-Myanmar border 2000–2018: a retrospective analysis (2024) · cites this paper as Landier et al., 2016
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Antimalarial Drug Discovery from Natural and Synthetic Sources
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Malaria elimination in West Java, Indonesia: A descriptive-and-qualitative study
Fauziah, N., Rinawan, F. R., Nugraha, N. F., Faridah, L., Jati, K. M., Dakosta, A., Kalya, S. M., Zakiyyudin, M. Y., Muhsin, A., Rizkillah, K. F., et al. (2024) · Journal of Vector Borne Diseases · doi:10.4103/jvbd.jvbd_113_23 · Cited by 3 · see citing works
- Authors
- Landier, J., Parker, D. M., Thu, A. M., Carrara, V. I., Lwin, K. M., Bonnington, C. A., Pukrittayakamee, S., Delmas, G., & Nosten, F. H.
- Affiliations
- Mahidol University (TH)
- Corresponding author
- Landier, Jordi
- ORCID
- Venue
- Malaria Journal
- Published
- 2016-07-15
- Volume
- 15
- Issue
- 1
- Pages
- 363-363
- ISSN
- 1475-2875 (ISSN-L)
- PMC
- PMC4946177
- OpenAlex
- W2463148194
- Cited by
- 170
- References
- 64
- Citations by year
- 2026: 8 · 2025: 23 · 2024: 18 · 2023: 13 · 2022: 33 · 2021: 24 · 2020: 13 · 2019: 10 · 2018: 14 · 2017: 12 · 2016: 2
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Malaria Journal (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- Bill and Melinda Gates Foundation
- Global Fund to Fight AIDS, Tuberculosis and Malaria
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Social Sciences › Arts and Humanities › History › History of Medicine and Tropical Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Travel-related health issues
- Keywords
- malaria elimination, early diagnosis and treatment, falciparum malaria, rapid diagnostic tests, artemisinin-based combination therapy, primaquine, community health workers, malaria surveillance, hard-to-reach populations, malaria transmission reduction
- MeSH terms
- Antimalarials, Diagnostic Tests, Routine, Drug Therapy, Combination, Humans, Lactones, Malaria, Primaquine, Disease Transmission, Infectious, Artemisinins, Early Diagnosis, Secondary Prevention, Disease Eradication
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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