Analysis of spleen histopathology, splenocyte composition and haematological parameters in four strains of mice infected with Plasmodium berghei K173
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Abstract
BACKGROUND: Malaria is a fatal disease that presents clinically as a continuum of symptoms and severity, which are determined by complex host-parasite interactions. Clearance of infection is believed to be accomplished by the spleen and mononuclear phagocytic system (MPS), independent of artemisinin treatment. The spleen filters infected red blood cells (RBCs) from circulation through immune-mediated recognition of the infected RBCs followed by phagocytosis. This study evaluated the tolerance of four different strains of mice to Plasmodium berghei strain K173 (P. berghei K173), and the differences in the role of the spleen in controlling P. berghei K173 infection. METHODS: Using different strains of mice (C57BL/6, BALB/C, ICR, and KM mice) infected with P. berghei K173, the mechanisms leading to splenomegaly, histopathology, splenocyte activation and proliferation, and their relationship to the control of parasitaemia and host mortality were examined and evaluated. RESULTS: Survival time of mice infected with P. berghei K173 varied, although the infection was uniformly lethal. Mice of the C57BL/6 strain were the most resistant, while mice of the strain ICR were the most susceptible. BALB/c and KM mice were intermediate. In the course of P. berghei K173 infection, all infected mice experienced significant splenomegaly. Parasites were observed in the red pulp at 3 days post infection (dpi) in all animals. All spleens retained late trophozoite stages as well as a fraction of earlier ring-stage parasites. The percentages of macrophages in infected C57BL/6 and KM mice were higher than uninfected mice on 8 dpi. Spleens of infected ICR and KM mice exhibited structural disorganization and remodelling. Furthermore, parasitaemia was significantly higher in KM versus C57BL/6 mice at 8 dpi. The percentages of macrophages in ICR infected mice were lower than uninfected mice, and the parasitaemia was higher than other strains. CONCLUSIONS: The results presented here demonstrate the rate of splenic mechanical filtration and that splenic macrophages are the predominant roles in controlling an individual's total parasite burden. This can influence the pathogenesis of malaria. Finally, different genetic backgrounds of mice have different splenic mechanisms for controlling malaria infection.
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The treated group showed an expansion of white pulp in the spleens compared to the control group.
“In addition, the treated group showed an expansion of white pulp, a major control center for the humoral immune response (56), in the spleens compared to the control group, as evidenced by hematoxylin and eosin (H&E) staining (Fig. 7H).”
From SRC kinase drives multidrug resistance induced by KRAS-G12C inhibition (2024) · cites this paper as [56]
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- Authors
- Wang, H., Li, S., Cui, Z., Qin, T., Shi, H., Ma, J., Li, L., Yu, G., Jiang, T., & Li, C.
- Affiliations
- China Academy of Chinese Medical Sciences (CN)
- Corresponding author
- Li, Canghai
- Venue
- Malaria Journal
- Published
- 2021-06-06
- Volume
- 20
- Issue
- 1
- Pages
- 249-249
- ISSN
- 1475-2875 (ISSN-L)
- PMC
- PMC8180108
- OpenAlex
- W3168760303
- Cited by
- 36
- References
- 49
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 4 · 2023: 5 · 2022: 4 · 2021: 1 · 2018: 1
- FWCI
- 3.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Malaria Journal (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81641002)
- National Major Scientific and Technological Special Project for “Significant New Drugs Development” (2017ZX09101002-002-005)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Immunology and Microbiology › Parasitology › Bird parasitology and diseases
- Health Sciences › Medicine › Physiology › Erythrocyte Function and Pathophysiology
- Keywords
- malaria, mouse strain differences, splenomegaly, spleen histopathology, splenic macrophages, host-parasite interactions, reticuloendothelial system, C57BL/6 mice, ICR mice, BALB/c mice
- MeSH terms
- Animals, Hematologic Tests, Malaria, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Inbred ICR, Plasmodium berghei, Spleen, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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