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Cited by 155Sperm and Testicular FunctionCoffee research and impactsReproductive Health and Technologies

The DOI matches its Crossref record; 62 of the 63 references it cites were found in a registry or an index.

Coffee and caffeine intake and male infertility: a systematic review

Open access
Ricci, Elena, Viganò, Paola, Cipriani, Sonia, Somigliana, Edgardo, Chiaffarino, Francesca, Bulfoni, Alessandro, Parazzini, Fabio·2017·Nutrition Journal
DOI 10.1186/s12937-017-0257-2PMC PMC5482951
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Abstract

BACKGROUND: Semen quality, a predictor of male fertility, has been suggested declining worldwide. Among other life style factors, male coffee/caffeine consumption was hypothesized to influence semen parameters, but also sperm DNA integrity. To summarize available evidence, we performed a systematic review of observational studies on the relation between coffee/caffeine intake and parameters of male fertility including sperm ploidy, sperm DNA integrity, semen quality and time to pregnancy. METHODS: A systematic literature search was performed up to November 2016 (MEDLINE and EMBASE). We included all observational papers that reported the relation between male coffee/caffeine intake and reproductive outcomes: 1. semen parameters, 2. sperm DNA characteristics, 3. fecundability. All pertinent reports were retrieved and the relative reference lists were systematically searched in order to identify any potential additional studies that could be included. RESULTS: We retrieved 28 papers reporting observational information on coffee/caffeine intake and reproductive outcomes. Overall, they included 19,967 men. 1. Semen parameters did not seem affected by caffeine intake, at least caffeine from coffee, tea and cocoa drinks, in most studies. Conversely, other contributions suggested a negative effect of cola-containing beverages and caffeine-containing soft drinks on semen volume, count and concentration. 2. As regards sperm DNA defects, caffeine intake seemed associated with aneuploidy and DNA breaks, but not with other markers of DNA damage. 3. Finally, male coffee drinking was associated to prolonged time to pregnancy in some, but not all, studies. CONCLUSIONS: The literature suggests that caffeine intake, possibly through sperm DNA damage, may negatively affect male reproductive function. Evidence from epidemiological studies on semen parameters and fertility is however inconsistent and inconclusive. Well-designed studies with predefined criteria for semen analysis, subject selection, and life style habits definition, are essential to reach a consistent evidence on the effect of caffeine on semen parameters and male fertility.

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Research works printed but not linked: 2

  1. Al-Inany HG, Dumoulin JCM, Evers JLH. Does bicycling really affect semen quality? Middle East Fert Soc J. 2001;6:250–3.
  2. Pecoraro A, Boeri L, Galdini A, Scano R, Ventimiglia E, Serino A, et al. Dietary habits and reproductive health – results of a sociological case-control study. Hum Rep. 2015;30(Suppl1):i126–7.

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Metadata

Authors
Ricci, E., Viganò, P., Cipriani, S., Somigliana, E., Chiaffarino, F., Bulfoni, A., & Parazzini, F.
Affiliations
  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
  • IRCCS Ospedale San Raffaele (IT)
  • University of Milan (IT)
Corresponding author
Ricci, Elena
ORCID
Venue
Nutrition Journal
Publisher
Springer Science and Business Media LLC
Published
2017-06-24
Volume
16
Issue
1
Pages
37-37
ISSN
1475-2891 (ISSN-L)
DOI
10.1186/s12937-017-0257-2
PMC
PMC5482951
OpenAlex
W2682414161
Cited by
155
References
63
Citations by year
2026: 10 · 2025: 17 · 2024: 23 · 2023: 17 · 2022: 23 · 2021: 20 · 2020: 21 · 2019: 10 · 2018: 12 · 2017: 2
FWCI
2.01
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Nutrition Journal (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Keywords
coffee consumption, caffeine consumption, male infertility, semen quality, sperm DNA damage, sperm aneuploidy, time to pregnancy, fecundability, cola beverages, soft drinks, male reproductive function
MeSH terms
Caffeine, Carbonated Beverages, Coffee, DNA Damage, Fertility, Humans, Infertility, Male, Male, Sperm Count, Sperm Motility, Spermatozoa, Semen Analysis, Observational Studies as Topic

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