The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Exosomal miRNAs and miRNA dysregulation in cancer-associated fibroblasts
Open accessAbstract
PURPOSE: The present review aimed to assess the role of exosomal miRNAs in cancer-associated fibroblasts (CAFs), normal fibroblasts (NFs), and cancer cells. The roles of exosomal miRNAs and miRNA dysregulation in CAF formation and activation were summarized. METHODS: All relevant publications were retrieved from the PubMed database, with key words such as CAFs, CAF, stromal fibroblasts, cancer-associated fibroblasts, miRNA, exosomal, exosome, and similar terms. RESULTS: Recent studies have revealed that CAFs, NFs, and cancer cells can secrete exosomal miRNAs to affect each other. Dysregulation of miRNAs and exosomal miRNAs influence the formation and activation of CAFs. Furthermore, miRNA dysregulation in CAFs is considered to be associated with a secretory phenotype change, tumor invasion, tumor migration and metastasis, drug resistance, and poor prognosis. CONCLUSIONS: Finding of exosomal miRNA secretion provides novel insights into communication among CAFs, NFs, and cancer cells. MicroRNA dysregulation is also involved in the whole processes of CAF formation and function. Dysregulation of miRNAs in CAFs can affect the secretory phenotype of the latter cells.
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Khalaf, K., Hana, D., Chou, J. T.-T., Singh, C., Mackiewicz, A., & Kaczmarek, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.656364 · Cited by 513
The role of exosomal PD-L1 in tumor progression and immunotherapy
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Role of hypoxia-induced exosomes in tumor biology
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Metadata
- Authors
- Yang, F., Ning, Z., Ma, L., Liu, W., Shao, C., Shu, Y., & Shen, H.
- Venue
- Molecular Cancer
- Published
- 2017-08-29
- Volume
- 16
- Issue
- 1
- Pages
- 148-148
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W2750999526
- Cited by
- 329
- References
- 117
- FWCI
- 9.22
- Type
- journal article
- Language
- en
- Open access
- gold
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