Microenvironmental regulation of tumor progression and metastasis

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

Hodi, F. S., O'Day, S. J., McDermott, D. F., Weber, R. W., Sosman, J. A., Haanen, J. B., Gonzalez, R., Robert, C., Schadendorf, D., Hassel, J. C., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1003466 · Cited by 15,155 · see citing works

Immunity, Inflammation, and Cancer

Grivennikov, S. I., Greten, F. R., & Karin, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.025 · Cited by 10,755 · see citing works

Tumor angiogenesis: therapeutic implications

Sherwood, L. M., Parris, E. E., & Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197111182852108 · Cited by 10,187 · see citing works

Epithelial-Mesenchymal Transitions in Development and Disease

Thiery, J. P., Acloque, H., Huang, R. Y. J., & Nieto, M. A. (2009) · Cell · doi:10.1016/j.cell.2009.11.007 · Cited by 9,931 · see citing works

Exploring the full spectrum of macrophage activation

Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

Mani, S. A., Guo, W., Liao, M.-J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., Brooks, M. W., Reinhard, F., Zhang, C. C., Shipitsin, M. V., et al. (2008) · Cell · doi:10.1016/j.cell.2008.03.027 · Cited by 8,679 · see citing works

Inflammation and cancer: back to Virchow?

Balkwill, F., & Mantovani, A. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04046-0 · Cited by 7,746 · see citing works

Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. Adults

Calle, E. E., Rodriguez, C., Walker-Thurmond, K., & Thun, M. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021423 · Cited by 7,696 · see citing works

Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

Schreiber, R. D., Old, L. J., & Smyth, M. J. (2011) · Science · doi:10.1126/science.1203486 · Cited by 6,474 · see citing works

Molecular mechanisms and clinical applications of angiogenesis

Carmeliet, P., & Jain, R. K. (2011) · Nature · doi:10.1038/nature10144 · Cited by 5,467 · see citing works

Macrophage Diversity Enhances Tumor Progression and Metastasis

Qian, B., & Pollard, J. W. (2010) · Cell · doi:10.1016/j.cell.2010.03.014 · Cited by 5,208 · see citing works

The immune contexture in human tumours: impact on clinical outcome

Fridman, W. H., Pagès, F., Sautès-Fridman, C., & Galon, J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3245 · Cited by 4,981 · see citing works

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

Hanahan, D., & Coussens, L. M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.022 · Cited by 4,632 · see citing works

Fibroblasts in cancer

Kalluri, R., & Zeisberg, M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1877 · Cited by 4,538 · see citing works

Myofibroblasts and mechano-regulation of connective tissue remodelling

Tomasek, J. J., Gabbiani, G., Hinz, B., Chaponnier, C., & Brown, R. A. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm809 · Cited by 4,290 · see citing works

Nivolumab plus Ipilimumab in Advanced Melanoma

Wolchok, J. D., Kluger, H., Callahan, M. K., Postow, M. A., Rizvi, N. A., Lesokhin, A. M., Segal, N. H., Ariyan, C. E., Gordon, R.-A., Reed, K., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1302369 · Cited by 4,230 · see citing works

Functions of natural killer cells

Vivier, E., Tomasello, E., Baratin, M., Walzer, T., & Ugolini, S. (2008) · Nature Immunology · doi:10.1038/ni1582 · Cited by 3,943 · see citing works

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840 · see citing works

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715 · see citing works

Microenvironmental regulation of metastasis

Joyce, J. A., & Pollard, J. W. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2618 · Cited by 3,684 · see citing works

Coordinated regulation of myeloid cells by tumours

Gabrilovich, D. I., Ostrand-Rosenberg, S., & Bronte, V. (2012) · Nature Reviews Immunology · doi:10.1038/nri3175 · Cited by 3,544 · see citing works

Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in Melanoma

Hamid, O., Robert, C., DAUD, A. I., Hodi, F. S., Hwu, W., Kefford, R. F., Wolchok, J. D., Hersey, P., Joseph, R. W., Weber, J. S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1305133 · Cited by 3,373 · see citing works

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

Kaplan, R. N., Riba, R. D., Zacharoulis, S., Bramley, A. H., Vincent, L., Costa, C., MacDonald, D. D., Jin, D. K., Shido, K., Kerns, S. A., et al. (2005) · Nature · doi:10.1038/nature04186 · Cited by 3,288 · see citing works

Neutrophils in the activation and regulation of innate and adaptive immunity

Mantovani, A., Cassatella, M. A., Costantini, C., & Jaillon, S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3024 · Cited by 3,044 · see citing works

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

Shankaran, V., Ikeda, H., Bruce, A. T., White, J. M., Swanson, P. E., Old, L. J., & Schreiber, R. D. (2001) · Nature · doi:10.1038/35074122 · Cited by 2,896 · see citing works

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

Qian, B.-Z., Li, J., Zhang, H., Kitamura, T., Zhang, J., Campion, L. R., Kaiser, E. A., Snyder, L. A., & Pollard, J. W. (2011) · Nature · doi:10.1038/nature10138 · Cited by 2,874 · see citing works

Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

Condeelis, J. S., & Pollard, J. W. (2006) · Cell · doi:10.1016/j.cell.2006.01.007 · Cited by 2,693 · see citing works

Transplacental Carcinogenesis by Stilbestrol

Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197108122850711 · Cited by 2,640 · see citing works

Metastasis: from dissemination to organ-specific colonization

Nguyen, D. X., Bos, P. D., & Massagué, J. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2622 · Cited by 2,637 · see citing works

Global burden of cancers attributable to infections in 2008: a review and synthetic analysis

de Martel, C., Ferlay, J., Franceschi, S., Vignat, J., Bray, F., Forman, D., & Plummer, M. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70137-7 · Cited by 2,540 · see citing works

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

Pyonteck, S. M., Akkari, L., Schuhmacher, A. J., Bowman, R. L., Sevenich, L., Quail, D. F., Olson, O. C., Quick, M. L., Huse, J. T., Teijeiro, V., et al. (2013) · Nature Medicine · doi:10.1038/nm.3337 · Cited by 2,463 · see citing works

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

Nieman, K. M., Kenny, H. A., Penicka, C. V., Ladanyi, A., Buell-Gutbrod, R., Zillhardt, M. R., Romero, I. L., Carey, M. S., Mills, G. B., Hotamisligil, G. S., et al. (2011) · Nature Medicine · doi:10.1038/nm.2492 · Cited by 2,279 · see citing works

Cancer immunotherapy via dendritic cells

Palucka, K., & Banchereau, J. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3258 · Cited by 2,060 · see citing works

Intra-tumour heterogeneity: a looking glass for cancer?

Marusyk, A., Almendro, V., & Polyák, K. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3261 · Cited by 2,003 · see citing works

Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

Lyden, D., Hattori, K., Dias, S., Costa, C., Blaikie, P., Butros, L., Chadburn, A., Heissig, B., Marks, W., Witte, L., et al. (2001) · Nature Medicine · doi:10.1038/nm1101-1194 · Cited by 1,860 · see citing works

Direct signaling between platelets and cancer cells induces an epithelial–mesenchymal-like transition and promotes metastasis

Labelle, M., Begum, S., & Hynes, R. O. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.09.009 · Cited by 1,833 · see citing works

Tumor angiogenesis: molecular pathways and therapeutic targets

Weis, S. M., & Cheresh, D. A. (2011) · Nature Medicine · doi:10.1038/nm.2537 · Cited by 1,739 · see citing works

Leukocyte Complexity Predicts Breast Cancer Survival and Functionally Regulates Response to Chemotherapy

DeNardo, D. G., Brennan, D. J., Rexhepaj, E., Ruffell, B., Shiao, S. L., Madden, S. F., Gallagher, W. M., Wadhwani, N., Keil, S. D., Junaid, S. A., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8274.cd-10-0028 · Cited by 1,715 · see citing works

Adoptive immunotherapy for cancer: harnessing the T cell response

Restifo, N. P., Dudley, M. E., & Rosenberg, S. A. (2012) · Nature Reviews Immunology · doi:10.1038/nri3191 · Cited by 1,688 · see citing works

CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

Beatty, G. L., Chiorean, E. G., Fishman, M. P., Saboury, B., Teitelbaum, U. R., Sun, W., Huhn, R. D., Song, W., Li, D., Sharp, L. L., et al. (2011) · Science · doi:10.1126/science.1198443 · Cited by 1,678 · see citing works

Models, mechanisms and clinical evidence for cancer dormancy

Aguirre‐Ghiso, J. A. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2256 · Cited by 1,673 · see citing works

Contribution of platelets to tumour metastasis

Gay, L. J., & Felding‐Habermann, B. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3004 · Cited by 1,646 · see citing works

The role of myeloid cells in the promotion of tumour angiogenesis

Murdoch, C., Muthana, M., Coffelt, S. B., & Lewis, C. E. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2444 · Cited by 1,642 · see citing works

Combining immunotherapy and targeted therapies in cancer treatment

Vanneman, M. W., & Dranoff, G. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3237 · Cited by 1,583 · see citing works

Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression

Bissell, M. J., & Hines, W. C. (2011) · Nature Medicine · doi:10.1038/nm.2328 · Cited by 1,516 · see citing works

Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner

Erez, N., Truitt, M., Olson, P., & Hanahan, D. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.041 · Cited by 1,515 · see citing works

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

Calvo, F., Ege, N., Grande-Garcia, A., Hooper, S., Jenkins, R. P., Chaudhry, S. I., Harrington, K., Williamson, P., Moeendarbary, E., Charras, G., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2756 · Cited by 1,478 · see citing works

Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium

Olumi, A., Grossfeld, G., Hayward, S., Carroll, P., Cunha, G., Hein, P., & Tlsty, T. (2000) · Breast Cancer Research · doi:10.1186/bcr138 · Cited by 1,463 · see citing works

Adaptive immunity maintains occult cancer in an equilibrium state

Koebel, C. M., Vermi, W., Swann, J. B., Zerafa, N., Rodig, S. J., Old, L. J., Smyth, M. J., & Schreiber, R. D. (2007) · Nature · doi:10.1038/nature06309 · Cited by 1,438 · see citing works

Signals from the Sympathetic Nervous System Regulate Hematopoietic Stem Cell Egress from Bone Marrow

Katayama, Y., Battista, M., Kao, W.-M., Hidalgo, A., Peired, A. J., Thomas, S. A., & Frenette, P. S. (2006) · Cell · doi:10.1016/j.cell.2005.10.041 · Cited by 1,412 · see citing works

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

Facciabene, A., Peng, X., Hagemann, I. S., Balint, K., Barchetti, A., Wang, L.-P., Gimotty, P. A., Gilks, C. B., Lal, P., Zhang, L., et al. (2011) · Nature · doi:10.1038/nature10169 · Cited by 1,376 · see citing works

Tumor-Infiltrating CD8+Lymphocytes Predict Clinical Outcome in Breast Cancer

Mahmoud, S., Paish, E. C., Powe, D. G., Macmillan, R. D., Grainge, M. J., Lee, A. H. S., Ellis, I. O., & Green, A. R. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.30.5037 · Cited by 1,367 · see citing works

The Matrisome: In Silico Definition and In Vivo Characterization by Proteomics of Normal and Tumor Extracellular Matrices

Naba, A., Clauser, K. R., Hoersch, S., Liu, H., Carr, S. A., & Hynes, R. O. (2012) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.014647 · Cited by 1,354 · see citing works

BMP-7 counteracts TGF-β1–induced epithelial-to-mesenchymal transition and reverses chronic renal injury

Zeisberg, M., Hanai, J., Sugimoto, H., Mammoto, T., Charytan, D. M., Strutz, F. M., & Kalluri, R. (2003) · Nature Medicine · doi:10.1038/nm888 · Cited by 1,345 · see citing works

Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer

Almand, B., Clark, J. I., Nikitina, E., van Beynen, J., English, N. R., Knight, S. C., Carbone, D. P., & Gabrilovich, D. I. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.678 · Cited by 1,340 · see citing works

Interactions between cancer stem cells and their niche govern metastatic colonization

Malanchi, I., Santamaria-Martínez, A., Susanto, E., Peng, H., Lehr, H.-A., Delaloye, J.-F., & Huelsken, J. (2012) · Nature · doi:10.1038/nature10694 · Cited by 1,339 · see citing works

Lessons from the Cancer Genome

Garraway, L. A., & Lander, E. S. (2013) · Cell · doi:10.1016/j.cell.2013.03.002 · Cited by 1,322 · see citing works

Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration

Luga, V., Zhang, L., Viloria-Petit, A. M., Ogunjimi, A. A., Inanlou, M. R., Chiu, E., Buchanan, M., Hosein, A. N., Basik, M., & Wrana, J. L. (2012) · Cell · doi:10.1016/j.cell.2012.11.024 · Cited by 1,311 · see citing works

The metastatic niche: adapting the foreign soil

Psaila, B., & Lyden, D. C. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2621 · Cited by 1,302 · see citing works

Autonomic nerve development contributes to prostate cancer progression

Magnon, C., Hall, S. J., Lin, J., Xue, X., Gerber, L., Freedland, S. J., & Frenette, P. S. (2013) · Science · doi:10.1126/science.1236361 · Cited by 1,287 · see citing works

Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial

Escudier, B. J., Dorval, T., Chaput, N., André, F., Caby, M.-P., Novault, S., Flament, C., Leboulaire, C., Borg, C., Amigorena, S., et al. (2005) · Journal of Translational Medicine · doi:10.1186/1479-5876-3-10 · Cited by 1,285 · see citing works

Tumors as Organs: Complex Tissues that Interface with the Entire Organism

Egeblad, M., Nakasone, E. S., & Werb, Z. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.05.012 · Cited by 1,230 · see citing works

Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy

Diaz-Montero, C. M., Salem, M. L., Nishimura, M. I., Garrett-Mayer, E. S., Cole, D. J., & Montero, A. J. (2008) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-008-0523-4 · Cited by 1,217 · see citing works

Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse.

Bates, G. J., Fox, S., Han, C., Leek, R., García, J. F., Harris, A., & Banham, A. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2006.05.9584 · Cited by 1,209 · see citing works

HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment

Corzo, C. A., Condamine, T., Lu, L., Cotter, M. J., Youn, J.-I., Cheng, P., Cho, H.-I., Celis, E., Quiceno, D. G., Padhya, T., et al. (2010) · Journal of Experimental Medicine · doi:10.1084/jem.20100587 · Cited by 1,173 · see citing works

History of myeloid-derived suppressor cells

Talmadge, J. E., & Gabrilovich, D. I. (2013) · Nature Reviews Cancer · doi:10.1038/nrc3581 · Cited by 1,148 · see citing works

The perivascular niche regulates breast tumour dormancy

Ghajar, C. M., Peinado, H., Mori, H., Matei, I. R., Evason, K. J., Brazier, H., Almeida, D., Koller, A., Hajjar, K. A., Stainier, D. Y. R., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2767 · Cited by 1,148 · see citing works

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

Du, R., Lu, K. V., Petritsch, C. K., Liu, P., Ganß, R., Passegue, E. A., Song, H., VandenBerg, S. R., Johnson, R. S., Werb, Z., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.01.034 · Cited by 1,131 · see citing works

A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer

Morse, M. A., Garst, J. L., Osada, T., Khan, S., Hobeika, A. C., Clay, T. M., Valente, N., Shreeniwas, R., Sutton, M. A., Delcayre, A. X., et al. (2005) · Journal of Translational Medicine · doi:10.1186/1479-5876-3-9 · Cited by 1,123 · see citing works

Macrophage Regulation of Tumor Responses to Anticancer Therapies

De Palma, M., & Lewis, C. E. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.02.013 · Cited by 1,079 · see citing works

Neutralizing Tumor-Promoting Chronic Inflammation: A Magic Bullet?

Coussens, L. M., Zitvogel, L., & Palucka, A. K. (2013) · Science · doi:10.1126/science.1232227 · Cited by 1,070 · see citing works

Natural selection of tumor variants in the generation of “tumor escape” phenotypes

Khong, H. T., & Restifo, N. P. (2002) · Nature Immunology · doi:10.1038/ni1102-999 · Cited by 1,058 · see citing works

Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors

Wyckoff, J. B., Wang, Y., Lin, E. Y., Li, J.-F., Goswami, S. K., Stanley, E. R., Segall, J. E., Pollard, J. W., & Condeelis, J. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1823 · Cited by 1,053 · see citing works

Discovery of Endothelial to Mesenchymal Transition as a Source for Carcinoma-Associated Fibroblasts

Zeisberg, E. M., Potenta, S., Xie, L., Zeisberg, M., & Kalluri, R. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-3127 · Cited by 1,011 · see citing works

Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell–mediated elimination of tumor cells

Palumbo, J. S., Talmage, K. E., Massari, J. V., Jeunesse, C. M. L., Flick, M. J., Kombrinck, K. W., Jiroušková, M., & Degen, J. L. (2004) · Blood · doi:10.1182/blood-2004-06-2272 · Cited by 1,000 · see citing works

Tumor Induction of VEGF Promoter Activity in Stromal Cells

Fukumura, D., Xavier, R., Sugiura, T., Chen, Y., Park, E.-C., Lu, N., Selig, M., Nielsen, G., Taksir, T., Jain, R. K., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81731-6 · Cited by 996 · see citing works

The polarization of immune cells in the tumour environment by TGFβ

Flavell, R. A., Sanjabi, S., Wrzesinski, S. H., & Licona-Limón, P. (2010) · Nature Reviews Immunology · doi:10.1038/nri2808 · Cited by 940 · see citing works

Intravital imaging of cell movement in tumours

Condeelis, J. S., & Segall, J. E. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1231 · Cited by 930 · see citing works

Cytokeratin-Positive Cells in the Bone Marrow and Survival of Patients with Stage I, II, or III Breast Cancer

Braun, S., Pantel, K., Müller, P. E., Janni, W., Hepp, F., Kentenich, C. R. M., Gastroph, S., Wischnik, A., Dimpfl, T., Kindermann, G., et al. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002243420801 · Cited by 923 · see citing works

Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues

Murdoch, C., Giannoudis, A., & Lewis, C. E. (2004) · Blood · doi:10.1182/blood-2004-03-1109 · Cited by 911 · see citing works

Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients

Fu, J., Xu, D., Liu, Z., Shi, M., Zhao, P., Fu, B., Zhang, Z., Yang, H., Zhang, H., Zhou, C., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.102 · Cited by 897 · see citing works

Role of Macrophage Targeting in the Antitumor Activity of Trabectedin

Germano, G., Frapolli, R., Belgiovine, C., Anselmo, A., Pesce, S., Liguori, M., Erba, E., Uboldi, S., Zucchetti, M., Pasqualini, F., et al. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.01.008 · Cited by 863 · see citing works

Aspirin Use, Tumor PIK3CA Mutation, and Colorectal-Cancer Survival

Liao, X., Lochhead, P. J., Nishihara, R., Morikawa, T., Kuchiba, A., Yamauchi, M., Imamura, Y., Qian, Z. R., Baba, Y., Shima, K., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1207756 · Cited by 842 · see citing works

De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent

de Visser, K. E., Korets, L. V., & Coussens, L. M. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.014 · Cited by 826 · see citing works

The immunosuppressive tumour network: myeloid‐derived suppressor cells, regulatory T cells and natural killer T cells

Lindau, D., Gielen, P. R., Kroesen, M., Wesseling, P., & Adema, G. J. (2012) · Immunology · doi:10.1111/imm.12036 · Cited by 817 · see citing works

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

Yamazaki, S., Ema, H., Karlsson, G., Yamaguchi, T., Miyoshi, H., Shioda, S., Taketo, M. M., Karlsson, S., Iwama, A., & Nakauchi, H. (2011) · Cell · doi:10.1016/j.cell.2011.09.053 · Cited by 797 · see citing works

Tumor-Associated Macrophages Express Lymphatic Endothelial Growth Factors and Are Related to Peritumoral Lymphangiogenesis

Schoppmann, S. F., Birner, P., Stöckl, J., Kalt, R., Ullrich, R., Caucig, C., Kriehuber, E., Nagy, K., Alitalo, K., & Kerjaschki, D. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64255-1 · Cited by 794 · see citing works

“Re-educating” tumor-associated macrophages by targeting NF-κB

Hagemann, T., Lawrence, T., McNeish, I., Charles, K. A., Kulbe, H., Thompson, R. G., Robinson, S. C., & Balkwill, F. R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080108 · Cited by 792 · see citing works

Tumor entrained neutrophils inhibit seeding in the premetastatic lung

Granot, Z., Henke, E., Comen, E. A., King, T. A., Norton, L., & Benezra, R. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.08.012 · Cited by 782 · see citing works

Non-Cell-Autonomous Tumor Suppression by p53

Lujambio, A., Akkari, L., Simon, J., Grace, D., Tschaharganeh, D. F., Bolden, J. E., Zhao, Z., Thapar, V., Joyce, J. A., Krizhanovsky, V., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.020 · Cited by 766 · see citing works

Adhesion Mechanisms in Platelet Function

Ruggeri, Z. M., & Mendolicchio, G. L. (2007) · Circulation Research · doi:10.1161/01.res.0000267878.97021.ab · Cited by 759 · see citing works

IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasionPreprint

Gocheva, V., Wang, H., Gadea, B. B., Shree, T., Hunter, K. E., Garfall, A. L., Berman, T. A., & Joyce, J. A. (2010) · Genes & Development · doi:10.1101/gad.1874010 · Cited by 739 · see citing works

Macrophages Promote the Invasion of Breast Carcinoma Cells via a Colony-Stimulating Factor-1/Epidermal Growth Factor Paracrine Loop

Goswami, S. K., Sahai, E. A., Wyckoff, J. B., Cammer, M., Cox, D., Pixley, F. J., Stanley, E. R., Segall, J. E., & Condeelis, J. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-1853 · Cited by 739 · see citing works

Tumor-associated neutrophils: friend or foe?

Fridlender, Z. G., & Albelda, S. Μ. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs123 · Cited by 699 · see citing works

Myeloid Suppressor Lines Inhibit T Cell Responses by an NO-Dependent Mechanism

Mazzoni, A., Bronte, V., Visintin, A., Spitzer, J. H., Apolloni, E., Serafini, P., Zanovello, P., & Segal, D. M. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.2.689 · Cited by 692 · see citing works

A Distinct Macrophage Population Mediates Metastatic Breast Cancer Cell Extravasation, Establishment and Growth

Qian, B., Deng, Y., Im, J. H., Muschel, R. J., Zou, Y., Li, J., Lang, R. A., & Pollard, J. W. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006562 · Cited by 664 · see citing works

Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis

Joyce, J. A., Baruch, A., Chehade, K. A. H., Meyer-Morse, N., Giraudo, E., Tsai, F., Greenbaum, D. C., Hager, J. H., Bogyo, M. S., & Hanahan, D. (2004) · Cancer Cell · doi:10.1016/s1535-6108(04)00111-4 · Cited by 643 · see citing works

Novel cancer immunotherapy agents with survival benefit: recent successes and next steps

Sharma, P., Wagner, K., Wolchok, J. D., & Allison, J. P. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3153 · Cited by 639 · see citing works

Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation

Landsberg, J., Sirokay, J. D., Renn, M., Bald, T., Rogava, M., Cron, M., Fatho, M., Lennerz, V., Wölfel, T., Hölzel, M., et al. (2012) · Nature · doi:10.1038/nature11538 · Cited by 635 · see citing works

Indoleamine 2,3-dioxygenase is a critical resistance mechanism in antitumor T cell immunotherapy targeting CTLA-4

Holmgaard, R., Zamarin, D., Munn, D. H., Wolchok, J. D., & Allison, J. P. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130066 · Cited by 633 · see citing works

Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis

Gao, D., Nolan, D. J., Mellick, A. S., Bambino, K., McDonnell, K., & Mittal, V. (2008) · Science · doi:10.1126/science.1150224 · Cited by 632 · see citing works

Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs

Chen, Q., Zhang, X. H.-F., & Massagué, J. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.08.025 · Cited by 619 · see citing works

Platelet-derived nucleotides promote tumor-cell transendothelial migration and metastasis via P2Y2 receptor.

Schumacher, D., Strilic, B., Sivaraj, K., Wettschureck, N., & Offermanns, S. (2013) · Cancer Cell · doi:10.1016/j.ccr.2013.05.008 · Cited by 614 · see citing works

Deciphering and Reversing Tumor Immune Suppression

Motz, G. T., & Coukos, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.07.005 · Cited by 600 · see citing works

Increased survival of cirrhotic patients with a hepatocellular carcinoma detected during surveillance☆

Sangiovanni, A., Ninno, E. D., Fasani, P., Fazio, C. D., Ronchi, G., Romeo, R., Morabito, A., de Franchis, R., & Colombo, M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.12.049 · Cited by 599 · see citing works

Macrophages and cathepsin proteases blunt chemotherapeutic response in breast cancer

Shree, T., Olson, O. C., Elie, B. T., Kester, J. C., Garfall, A. L., Simpson, K., Bell-McGuinn, K. M., Zabor, E. C., Brogi, E., & Joyce, J. A. (2011) · Genes & Development · doi:10.1101/gad.180331.111 · Cited by 541 · see citing works

Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells

Gabrilovich, D. I., Velders, M. P., Sotomayor, E. M., & Kast, W. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.9.5398 · Cited by 538 · see citing works

Perineural Invasion Is an Independent Predictor of Outcome in Colorectal Cancer

Liebig, C., Ayala, G., Wilks, J. A., Verstovsek, G., Liu, H., Agarwal, N., Berger, D. H., & Albo, D. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.22.4949 · Cited by 524 · see citing works

Circulating tumour cells in non-metastatic breast cancer: a prospective study

Lucci, A., Hall, C. S., Lodhi, A., Bhattacharyya, A., Anderson, A. E., Xiao, L., Bedrosian, I., Kuerer, H. M., & Krishnamurthy, S. (2012) · The Lancet Oncology · doi:10.1016/s1470-2045(12)70209-7 · Cited by 507 · see citing works

Role of Angiogenesis in Human Tumor Dormancy: Animal Models of the Angiogenic Switch

Naumov, G. N., Akslen, L. A., & Folkman, J. (2006) · Cell Cycle · doi:10.4161/cc.5.16.3018 · Cited by 499 · see citing works

VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors

Lü, X., Mu, E. W., Wei, Y., Riethdorf, S., Yang, Q., Yuan, M., Yan, J., Hua, Y., Tiede, B., Lu, X., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.11.002 · Cited by 494 · see citing works

Inflammation and Increased Aromatase Expression Occur in the Breast Tissue of Obese Women with Breast Cancer

Morris, P. G., Hudis, C. A., Giri, D. D., Morrow, M., Falcone, D. J., Zhou, X. K., Du, B., Brogi, E., Crawford, C. B., Kopelovich, L., et al. (2011) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-11-0110 · Cited by 466 · see citing works

Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease

Sinha, P., Clements, V. K., & Ostrand‐Rosenberg, S. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.2.636 · Cited by 461 · see citing works

Cancer incidence and risk factors after solid organ transplantation

Vajdic, C. M., & van Leeuwen, M. T. (2009) · International Journal of Cancer · doi:10.1002/ijc.24439 · Cited by 460 · see citing works

Immune Surveillance Properties of Human NK Cell-Derived Exosomes

Lugini, L., Cecchetti, S., Huber, V., Luciani, F., Macchia, G., Spadaro, F., Paris, L., Abalsamo, L., Colone, M., Molinari, A., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101988 · Cited by 455 · see citing works

Agonistic CD40 Antibodies and Cancer Therapy

Vonderheide, R. H., & Glennie, M. J. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2064 · Cited by 443 · see citing works

Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of Vegf-A

Conejo-Garcia, J. R., Benencia, F., Courreges, M. C., Kang, E. H., Mohamed-Hadley, A. A., Buckanovich, R. J., Holtz, D. O., Jenkins, A., Na, H., Zhang, L., et al. (2004) · Nature Medicine · doi:10.1038/nm1097 · Cited by 438 · see citing works

The BMP Inhibitor Coco Reactivates Breast Cancer Cells at Lung Metastatic Sites

Gao, H., Chakraborty, G., Lee-Lim, A. P., Mo, Q., Decker, M., Vonica, A., Shen, R., Brogi, E., Brivanlou, A. H., & Giancotti, F. G. (2012) · Cell · doi:10.1016/j.cell.2012.06.035 · Cited by 430 · see citing works

Microglial Stimulation of Glioblastoma Invasion Involves Epidermal Growth Factor Receptor (EGFR) and Colony Stimulating Factor 1 Receptor (CSF-1R) Signaling

Coniglio, S. J., Eugenin, E., Dobrenis, K., Stanley, E. R., West, B. L., Symons, M. H., & Segall, J. E. (2012) · Molecular Medicine · doi:10.2119/molmed.2011.00217 · Cited by 429 · see citing works

Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma

Zhang, X. H.-F., Jin, X., Malladi, S., Zou, Y., Wen, Y. H., Brogi, E., Smid, M., Foekens, J. A., & Massagué, J. (2013) · Cell · doi:10.1016/j.cell.2013.07.036 · Cited by 425 · see citing works

Localization and Density of Immune Cells in the Invasive Margin of Human Colorectal Cancer Liver Metastases Are Prognostic for Response to Chemotherapy

Halama, N., Michel, S., Kloor, M., Zoernig, I., Benner, A., Spille, A., Pommerencke, T., von Knebel, D. M., Folprecht, G., Luber, B., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-0268 · Cited by 421 · see citing works

Macrophage Responses to Hypoxia

Lewis, C., & Murdoch, C. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62038-x · Cited by 413 · see citing works

Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth

Purhonen, S., Palm, J., Rossi, D. J., Kaskenpää, N., Rajantie, I., Ylä‐Herttuala, S., Alitalo, K. K., Weissman, I. L., & Salvén, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710516105 · Cited by 399 · see citing works

EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma

Liu, D., Ghiso, J. A. A., Estrada, Y. D., & Ossowski, L. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00072-7 · Cited by 392 · see citing works

Extracellular matrix signature identifies breast cancer subgroups with different clinical outcome

Bergamaschi, A., Tagliabue, E., Sørlie, T., Naume, B., Triulzi, T., Orlandi, R., Russnes, H., Nesland, J. M., Tammi, R., Auvinen, P., et al. (2007) · The Journal of Pathology · doi:10.1002/path.2278 · Cited by 387 · see citing works

Mesenchymal stem cells derived from bone marrow favor tumor cell growth in vivo

Zhu, W., Xu, W., Jiang, R., Qian, H., Chen, M., Hu, J., Cao, W., Han, C., & Chen, Y. (2006) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2005.07.004 · Cited by 386 · see citing works

Interaction of tumor cells and lymphatic vessels in cancer progression

Alitalo, A. K., & Detmar, M. J. (2011) · Oncogene · doi:10.1038/onc.2011.602 · Cited by 385 · see citing works

Cancer-Related Axonogenesis and Neurogenesis in Prostate Cancer

Ayala, G. E., Dai, H., Powell, M., Li, R., Ding, Y., Wheeler, T. M., Shine, D., Kadmon, D., Thompson, T., Miles, B. J., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-1164 · Cited by 380 · see citing works

Primary Tumor Hypoxia Recruits CD11b+/Ly6Cmed/Ly6G+ Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche

Sceneay, J., Chow, M. T., Chen, A., Halse, H. M., Wong, C. S. F., Andrews, D. M., Sloan, E. K., Parker, B. S., Bowtell, D. D. L., Smyth, M. J., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3873 · Cited by 365 · see citing works

Risk of colorectal high-grade dysplasia and cancer in a prospective observational cohort of patients with inflammatory bowel disease

Beaugerie, L., Svrcek, M., Seksik, P., Bouvier, A., Simon, T., Allez, M., Brixi, H., Gornet, J., Altwegg, R., Beau, P., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.03.044 · Cited by 363 · see citing works

Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants

Kerjaschki, D., Huttary, N., Raab, I., Regele, H. M., Bojarski-Nagy, K., Bond, G., Kröber, S. M., Greinix, H. T., Rosenmaier, A., Karlhofer, F. M., et al. (2006) · Nature Medicine · doi:10.1038/nm1340 · Cited by 358 · see citing works

Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice

Gil‐Bernabé, A. M., Ferjancic, S., Tlalka, M., Zhao, L., Allen, P. D., Im, J. H., Watson, K., Hill, S. A., Amirkhosravi, A., Francis, J. L., et al. (2012) · Blood · doi:10.1182/blood-2011-08-376426 · Cited by 353 · see citing works

Tumor Microenvironment of Metastasis in Human Breast Carcinoma: A Potential Prognostic Marker Linked to Hematogenous Dissemination

Robinson, B. D., Sica, G., Liu, Y.-F., Rohan, T. E., Gertler, F. B., Condeelis, J. S., & Jones, J. G. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2179 · Cited by 344 · see citing works

Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy.

Naumov, G. N., MacDonald, I. C., Weinmeister, P. M., Kerkvliet, N. I., Nadkarni, K. V., Wilson, S. M., Morris, V. L., Groom, A. C., & Chambers, A. F. (2002) · PubMed · Cited by 341 · see citing works

CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients

Rech, A. J., Mick, R., Martin, S., Recio, A., Aqui, N. A., Powell, D. J., Colligon, T. A., Trosko, J. A., Leinbach, L. I., Pletcher, C. H., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003330 · Cited by 335 · see citing works

High frequency of tumor‐infiltrating FOXP3+ regulatory T cells predicts improved survival in mismatch repair‐proficient colorectal cancer patients

Frey, D. M., Droeser, R. A., Viehl, C. T., Zlobec, I., Lugli, A., Zingg, U., Oertli, D., Kettelhack, C., Terracciano, L., & Tornillo, L. (2009) · International Journal of Cancer · doi:10.1002/ijc.24989 · Cited by 335 · see citing works

Expansion of spleen myeloid suppressor cells represses NK cell cytotoxicity in tumor-bearing host

Liu, C., Yu, S., Kappes, J. C., Wang, J., Grizzle, W. E., Zinn, K. R., & Zhang, H. (2007) · Blood · doi:10.1182/blood-2006-09-046201 · Cited by 335 · see citing works

Mesenchymal to Epithelial Transition in Development and Disease

Chaffer, C. L., Thompson, E. W., & Williams, E. D. (2007) · Cells Tissues Organs · doi:10.1159/000101298 · Cited by 322 · see citing works

Immune microenvironments in solid tumors: new targets for therapyPreprint

Shiao, S. L., Ganesan, A.-P., Rugo, H. S., & Coussens, L. M. (2011) · Genes & Development · doi:10.1101/gad.169029.111 · Cited by 320 · see citing works

Myeloid Progenitor Cells in the Premetastatic Lung Promote Metastases by Inducing Mesenchymal to Epithelial Transition

Gao, D., Joshi, N., Choi, H., Ryu, S., Hahn, M., Catena, R., Sadik, H., Argani, P., Wagner, P. L., Vahdat, L. T., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-2905 · Cited by 308 · see citing works

Epithelial to Mesenchymal Transition in Human Breast Cancer Can Provide a Nonmalignant Stroma

PETERSEN, O. W., Nielsen, H. L., Guðjónsson, Þ., Villadsen, R., Rank, F. E., Niebuhr, E., Bissell, M. J., & Rønnov‐Jessen, L. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63834-5 · Cited by 305 · see citing works

Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids

Roodhart, J. M. L., Daenen, L. G. M., Stigter, E. C. A., Prins, H.-J., Gerrits, J., Houthuijzen, J. M., Gerritsen, M. G., Schipper, H. S., Backer, M. J. G., van Amersfoort, M., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.08.010 · Cited by 305 · see citing works

Intratumoral macrophages contribute to epithelial-mesenchymal transition in solid tumors

Bonde, A.-K., Tischler, V., Kumar, S., Soltermann, A., & Schwendener, R. A. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-35 · Cited by 284 · see citing works

Targeting the Tumor Microenvironment: From Understanding Pathways to Effective Clinical Trials

Hua, F., & DeClerck, Y. A. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-0661 · Cited by 282 · see citing works

The evolution of the cancer niche during multistage carcinogenesis

Barcellos‐Hoff, M. H., Lyden, D. C., & Wang, T. C. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3536 · Cited by 275 · see citing works

Fibroblasts as architects of cancer pathogenesis

Marsh, T., Pietras, K., & McAllister, S. S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.10.013 · Cited by 263 · see citing works

Re-polarization of tumor-associated macrophages to pro-inflammatory M1 macrophages by microRNA-155

Cai, X. F., Yin, Y., Li, N., Zhu, D., Zhang, J., Zhang, C., & Zen, K. (2012) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjs044 · Cited by 260 · see citing works

Intratumoral Injection of CpG Oligonucleotides Induces the Differentiation and Reduces the Immunosuppressive Activity of Myeloid-Derived Suppressor Cells

Shirota, Y., Shirota, H., & Klinman, D. M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101304 · Cited by 254 · see citing works

Human Bone Marrow-Derived Mesenchymal Stem Cells Suppress Human Glioma Growth Through Inhibition of Angiogenesis

Ho, I. A. W., Toh, H. C., Ng, W. H., Teo, Y. L., Guo, C. M., Hui, K. M., & Lam, P. Y. P. (2012) · Stem Cells · doi:10.1002/stem.1247 · Cited by 237 · see citing works

Incidence of de-novo breast cancer in women chronically immunosuppressed after organ transplantation

Stewart, T. H. M., Tsai, S.-C., Grayson, H., et al. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91618-0 · Cited by 235 · see citing works

Stromal Progenitor Cells from Endogenous Adipose Tissue Contribute to Pericytes and Adipocytes That Populate the Tumor Microenvironment

Zhang, Y., Daquinag, A. C., Amaya-Manzanares, F., Sirin, O., Tseng, C., & Kolonin, M. G. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0294 · Cited by 233 · see citing works

In Vivo Imaging in CancerPreprint

Condeelis, J. S., & Weissleder, R. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003848 · Cited by 231 · see citing works

Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors

Shime, H., Matsumoto, M., Oshiumi, H., Tanaka, S., Nakane, A., Iwakura, Y., Tahara, H., Inoue, N., & Seya, T. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113099109 · Cited by 224 · see citing works

IL-2–dependent tuning of NK cell sensitivity for target cells is controlled by regulatory T cells

Gasteiger, G., Hemmers, S., Firth, M. A., Floc’h, A. L., Huse, M., Sun, J. C.-Y., & Rudensky, A. Y. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20122462 · Cited by 224 · see citing works

The significant role of mast cells in cancer

Khazaie, K., Blatner, N. R., Khan, M. W., Gounari, F., Gounaris, E. G., Dennis, K. L., Bonertz, A., Tsai, F., Strouch, M. J., Cheon, E. C., et al. (2011) · Cancer and Metastasis Reviews · doi:10.1007/s10555-011-9286-z · Cited by 222 · see citing works

Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer

von Boehmer, H., & Daniel, C. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3683 · Cited by 221 · see citing works

Expression of RORγt Marks a Pathogenic Regulatory T Cell Subset in Human Colon Cancer

Blatner, N. R., Mulcahy, M. F., Dennis, K. L., Scholtens, D. M., Bentrem, D. J., Phillips, J. D., Ham, S., Sandall, B. P., Khan, M. W., Mahvi, D. M., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004566 · Cited by 214 · see citing works

Critical Steps in Hematogenous Metastasis

Chambers, A. F., Naumov, G. N., Varghese, H. J., Nadkarni, K. V., MacDonald, I. C., & Groom, A. C. (2001) · Surgical Oncology Clinics of North America · doi:10.1016/s1055-3207(18)30063-2 · Cited by 210 · see citing works

Direct Genetic Analysis of Single Disseminated Cancer Cells for Prediction of Outcome and Therapy Selection in Esophageal Cancer

Stoecklein, N. H., Hosch, S. B., Bezler, M., Stern, F., Hartmann, C. H., Vay, C., Siegmund, A., Scheunemann, P., Schurr, P., Knoefel, W. T., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.04.005 · Cited by 209 · see citing works

Mesenchymal stem cells in tumor development

Cuiffo, B., & Karnoub, A. E. (2012) · Cell Adhesion & Migration · doi:10.4161/cam.20875 · Cited by 204 · see citing works

Dendritic Cell–Derived Exosomes Need To Activate Both T and B Cells To Induce Antitumor Immunity

Näslund, T. I., Gehrmann, U., Qazi, K. R., Karlsson, M. C. I., & Gabrielsson, S. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203082 · Cited by 203 · see citing works

Cancer–stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis, and metastasis

Semenza, G. L. (2012) · Oncogene · doi:10.1038/onc.2012.578 · Cited by 201 · see citing works

Breast Fibroblasts Modulate Early Dissemination, Tumorigenesis, and Metastasis through Alteration of Extracellular Matrix Characteristics

Dumont, N., Liu, B., DeFilippis, R. A., Chang, H., Rabban, J. T., Karnezis, A. N., Tjoe, J. A., Marx, J., Parvin, B., & Tlsty, T. D. (2013) · Neoplasia · doi:10.1593/neo.121950 · Cited by 192 · see citing works

Critical steps in hematogenous metastasis: an overview.

Chambers, A. F., Naumov, G. N., Varghese, H. J., Nadkarni, K. V., MacDonald, I. C., & Groom, A. C. (2001) · PubMed · Cited by 191 · see citing works

Adipocytes Impair Leukemia Treatment in Mice

Behan, J. W., Yun, J. P., Proektor, M. P., Ehsanipour, E. A., Arutyunyan, A., Moses, A. S., Avramis, V. I., Louie, S. G., Butturini, A. M., Heisterkamp, N., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0800 · Cited by 183 · see citing works

Hypoxia Promotes Tumor Growth in Linking Angiogenesis to Immune Escape

Chouaı̈b, S., Messai, Y., Couvé, S., Escudier, B. J., Hasmim, M., & Noman, M. Z. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00021 · Cited by 180 · see citing works

Alternative activation of tumor-associated macrophages by IL-4

Wang, H., & Joyce, J. A. (2010) · Cell Cycle · doi:10.4161/cc.9.24.14322 · Cited by 177 · see citing works

Hepatic tumor–stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge

van Zijl, F., Mair, M., Csiszar, A., Schneller, D., Zulehner, G., Huber, H., Eferl, R., Beug, H., Dolznig, H., & Mikulits, W. (2009) · Oncogene · doi:10.1038/onc.2009.253 · Cited by 174 · see citing works

Partial Mesenchymal to Epithelial Reverting Transition in Breast and Prostate Cancer Metastases

Chao, Y. L., Wu, Q., Acquafondata, M. B., Dhir, R., & Wells, A. H. (2011) · Cancer Microenvironment · doi:10.1007/s12307-011-0085-4 · Cited by 170 · see citing works

Tumour-associated macrophages and cancer

Cook, J. A., & Hagemann, T. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.05.017 · Cited by 165 · see citing works

Impact of pretreatment thrombocytosis on survival in primary breast cancer

Salat, A., Gnant, M., Kwasny, W., et al. (2003) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613413 · Cited by 159 · see citing works

Cancer Incidence in New York State Acquired Immunodeficiency Syndrome Patients

Gallagher, B. K. (2001) · American Journal of Epidemiology · doi:10.1093/aje/154.6.544 · Cited by 149 · see citing works

Impact of tumor‐associated macrophages on invasive ductal carcinoma of the pancreas head

Yoshikawa, K., Mitsunaga, S., Kinoshitá, T., Konishi, M., Takahashi, S., Gotohda, N., Kato, Y., Aizawa, M., & Ochiai, A. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02411.x · Cited by 137 · see citing works

Probing the Microenvironment of Mammary Tumors Using Multiphoton Microscopy

Sidani, M., Wyckoff, J. B., Xue, C., Segall, J. E., & Condeelis, J. S. (2006) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-006-9021-5 · Cited by 136 · see citing works

Bone Marrow–Derived Gr1+ Cells Can Generate a Metastasis-Resistant Microenvironment Via Induced Secretion of Thrombospondin-1

Catena, R., Bhattacharya, N., Rayes, T. E., Wang, S., Choi, H., Gao, D., Ryu, S., Joshi, N., Bielenberg, D. R., Lee, S. B., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0476 · Cited by 131 · see citing works

Nerve-cancer interactions in the stromal biology of pancreatic cancer

Demir, İ. E. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00097 · Cited by 128 · see citing works

Identification of stromally expressed molecules in the prostate by tag-profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate

Orr, B. A., Riddick, A. C. P., Stewart, G. D., Anderson, R. A., Franco, O. E., Hayward, S. W., & Thomson, A. A. (2011) · Oncogene · doi:10.1038/onc.2011.312 · Cited by 124 · see citing works

Induced and natural regulatory T cells in human cancer

Whiteside, T. L., Schuler, P. J., & Schilling, B. (2012) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2012.707184 · Cited by 124 · see citing works

IL-2–dependent adaptive control of NK cell homeostasis

Gasteiger, G., Hemmers, S., Bos, P. D., Sun, J. C.-Y., & Rudensky, A. Y. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20122571 · Cited by 123 · see citing works

Detection of minimal residual disease in blood and bone marrow in early stage breast cancer

Krishnamurthy, S., Cristofanilli, M., Singh, B., et al. (2010) · Cancer · doi:10.1002/cncr.25145 · Cited by 119 · see citing works

Cancer and viral infections in immunocompromised individuals

Schulz, T. F. (2009) · International Journal of Cancer · doi:10.1002/ijc.24741 · Cited by 118 · see citing works

Myeloid Cells Contribute to Tumor Lymphangiogenesis

Zumsteg, A., Baeriswyl, V., Imaizumi, N., Schwendener, R. A., Rüegg, C., & Christofori, G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007067 · Cited by 115 · see citing works

Expression of drug resistance proteins in breast cancer, in relation to chemotherapy

Linn, S. C., Pinedo, H. M., van Ark-Otte, J., van der Valk, P., Hoekman, K., Honkoop, A. H., Vermorken, J. B., & Giaccone, G. (1997) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19970529)71:5 · Cited by 112 · see citing works

Tissue Factor Pathway Inhibitor Reduces Experimental Lung Metastasis of B16 Melanoma

Meyer, T. V., Chang, J.-Y., Amaya, M., et al. (2002) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1613114 · Cited by 100 · see citing works

Tumor Progression Stage and Anatomical Site Regulate Tumor-Associated Macrophage and Bone Marrow-Derived Monocyte Polarization

Redente, E. F., Dwyer‐Nield, L. D., Merrick, D., Raina, K., Agarwal, R., Pao, W. J., Rice, P. L., Shroyer, K. R., & Malkinson, A. M. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090879 · Cited by 94 · see citing works

Opposing Roles of Mitogenic and Stress Signaling Pathways in the Induction of Cancer Dormancy

Ranganathan, A. C., Adam, A. P., & Aguirre‐Ghiso, J. A. (2006) · Cell Cycle · doi:10.4161/cc.5.16.3109 · Cited by 92 · see citing works

Increased preoperative platelet count is associated with decreased survival after resection for adenocarcinoma of the pancreas

Brown, K. M., Domin, C., Aranha, G. V., et al. (2005) · The American Journal of Surgery · doi:10.1016/j.amjsurg.2004.11.014 · Cited by 89 · see citing works

Tie2-expressing monocytes (TEMs): Novel targets and vehicles of anticancer therapy?

Palma, M. D., & Naldini, L. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.04.001 · Cited by 85 · see citing works

Mesenchymal Stem Cells Provide an Advantageous Tumor Microenvironment for the Restoration of Cancer Stem Cells

Nishimura, K., Semba, S., Aoyagi, K., Sasaki, H., & Yokozaki, H. (2012) · Pathobiology · doi:10.1159/000337296 · Cited by 85 · see citing works

Preoperative thrombocytosis predicts poor survival in patients with glioblastoma

Brockmann, M. A., Giese, A., Mueller, K., Finjap, J. K., Lohr, F., Weiß, C., Gottschalk, S., Nolte, I. J. A., Leppert, J., Tuettenberg, J., et al. (2007) · Neuro-Oncology · doi:10.1215/15228517-2007-013 · Cited by 81 · see citing works

Mechanisms Linking Tumor Cell–Associated Procoagulant Function to Tumor Dissemination

Palumbo, J. S. (2008) · Seminars in Thrombosis and Hemostasis · doi:10.1055/s-2008-1079255 · Cited by 77 · see citing works

VEGFR1-activity-independent metastasis formation

Dawson, M., Duda, D. G., Fukumura, D., & Jain, R. K. (2009) · Nature · doi:10.1038/nature08254 · Cited by 75 · see citing works

Clinical opportunities and challenges in targeting tumour dormancy

Hensel, J. A., Flaig, T. W., & Theodorescu, D. (2012) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2012.207 · Cited by 68 · see citing works

Influence of low oxygen tensions on macrophage polarization

Escribese, M. M., Casas, M., & Corbí, A. L. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.07.002 · Cited by 68 · see citing works

Endothelial progenitor cells are cellular hubs essential for neoangiogenesis of certain aggressive adenocarcinomas and metastatic transition but not adenomas

Kerbel, R. S., Benezra, R., Lyden, D. C., Hattori, K., Heissig, B., Nolan, D. J., Mittal, V., Shaked, Y., Dias, S., Bertolini, F., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804876105 · Cited by 55 · see citing works

Treating Cancer by Targeting the Immune System

Hwu, P. (2010) · New England Journal of Medicine · doi:10.1056/nejme1006416 · Cited by 49 · see citing works

Heparanase promotes lymphangiogenesis and tumor invasion in pancreatic neuroendocrine tumors

Hunter, K. E., Palermo, C., Kester, J. C., Simpson, K., Li, J.-P., Tang, L. H., Klimstra, D. S., Vlodavsky, I., & Joyce, J. A. (2013) · Oncogene · doi:10.1038/onc.2013.142 · Cited by 45 · see citing works

Clinical significance of proliferative potential of occult metastatic cells in bone marrow of patients with breast cancer

Pierga, J., Bonneton, C., Magdelénat, H., et al. (2003) · British Journal of Cancer · doi:10.1038/sj.bjc.6601121 · Cited by 31 · see citing works

Understanding the tumor immune microenvironment (TIME) for effective therapy

Binnewies, M., Roberts, E. W., Kersten, K., Chan, V., Fearon, D. F., Merad, M., Coussens, L. M., Gabrilovich, D. I., Ostrand-Rosenberg, S., Hedrick, C. C., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0014-x · Cited by 6,145 · see citing works

Cancer nanomedicine: progress, challenges and opportunities

Shi, J., Kantoff, P. W., Wooster, R., & Farokhzad, O. C. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.108 · Cited by 5,873 · see citing works

The biology and function of fibroblasts in cancer

Kalluri, R. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.73 · Cited by 4,366 · see citing works

Tumor-Associated Macrophages: From Mechanisms to Therapy

Noy, R., & Pollard, J. W. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.010 · Cited by 4,089 · see citing works

The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth

de Visser, K. E., & Joyce, J. A. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.016 · Cited by 4,059 · see citing works

New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

Dongre, A., & Weinberg, R. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0080-4 · Cited by 3,876 · see citing works

CAR-T cell therapy: current limitations and potential strategies

Sterner, R. C., & Sterner, R. M. (2021) · Blood Cancer Journal · doi:10.1038/s41408-021-00459-7 · Cited by 2,926 · see citing works

NF-κB, inflammation, immunity and cancer: coming of age

Taniguchi, K., & Karin, M. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.142 · Cited by 2,679 · see citing works

EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

Shibue, T., & Weinberg, R. A. (2017) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2017.44 · Cited by 2,539 · see citing works

Crosstalk between cancer‐associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

Mao, X., Xu, J., Wang, W., Liang, C., Hua, J., Liu, J., Zhang, B., Meng, Q., Yu, X., & Shi, S. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01428-1 · Cited by 2,290 · see citing works

Roles of the immune system in cancer: From tumor initiation to metastatic progression

Gonzalez, H., Hagerling, C., & Werb, Z. (2018) · Genes & Development · doi:10.1101/gad.314617.118 · Cited by 2,111 · see citing works

Metastatic colonization by circulating tumour cells

Massagué, J., & Obenauf, A. C. (2016) · Nature · doi:10.1038/nature17038 · Cited by 2,062 · see citing works

Pre-metastatic niches: organ-specific homes for metastases

Peinado, H., Zhang, H., Matei, I. R., Costa-Silva, B., Hoshino, A., Rodrigues, G., Psaila, B., Kaplan, R. N., Bromberg, J. F., Kang, Y., et al. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.6 · Cited by 1,889 · see citing works

Tumor microenvironment complexity and therapeutic implications at a glance

Baghban, R., Roshangar, L., Jahanban-Esfahlan, R., Seidi, K., Ebrahimi-Kalan, A., Jaymand, M., Kolahian, S., Javaheri, T., & Zare, P. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-0530-4 · Cited by 1,784 · see citing works

Tumor microenvironment and therapeutic response

Wu, T., & Dai, Y. (2017) · Cancer Letters · doi:10.1016/j.canlet.2016.01.043 · Cited by 1,802 · see citing works

Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications

Lin, Y., Xu, J., & Lan, H. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0760-3 · Cited by 1,398 · see citing works

Clinical and therapeutic relevance of cancer-associated fibroblasts

Chen, Y., McAndrews, K. M., & Kalluri, R. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00546-5 · Cited by 1,230 · see citing works

Tumor-associated macrophages: an accomplice in solid tumor progression

Chen, Y., Song, Y., Du, W., Gong, L., Chang, H., & Zou, Z. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0568-z · Cited by 1,096 · see citing works

Targeting the tumour stroma to improve cancer therapy

Valkenburg, K. C., de Groot, A. E., & Pienta, K. J. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0007-1 · Cited by 1,084 · see citing works

Kinase inhibitors: the road ahead

Ferguson, F. M., & Gray, N. S. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.21 · Cited by 1,009 · see citing works

Tumor Microenvironment Characterization in Gastric Cancer Identifies Prognostic and Immunotherapeutically Relevant Gene Signatures

Zeng, D., Li, M., Zhou, R., Zhang, J., Sun, H., Shi, M., Bin, J., Liao, Y., Rao, J., & Liao, W. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0436 · Cited by 986 · see citing works

The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis

Hirayama, D., Iida, T., & Nakase, H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms19010092 · Cited by 927 · see citing works

Challenges to curing primary brain tumours

Aldape, K., Brindle, K. M., Chesler, L., Chopra, R., Gajjar, A., Gilbert, M. R., Gottardo, N., Gutmann, D. H., Hargrave, D., Holland, E. C., et al. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0177-5 · Cited by 959 · see citing works

Three-dimensional culture systems in cancer research: Focus on tumor spheroid model

Nath, S., & Devi, G. R. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.03.013 · Cited by 919 · see citing works

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy

Liu, T., Han, C., Wang, S., Fang, P., Ma, Z., Xu, L., & Yin, R. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0770-1 · Cited by 860 · see citing works

Tumor-associated macrophages: from basic research to clinical application

Yang, L., & Zhang, Y. (2017) · Journal of Hematology & Oncology · doi:10.1186/s13045-017-0430-2 · Cited by 847 · see citing works

CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer

Hu, J. L., Wang, W., Lan, X. L., Zeng, Z. C., Liang, Y. S., Yan, Y. R., Song, F. Y., Wang, F. F., Zhu, X. H., Liao, W. J., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1019-x · Cited by 773 · see citing works

Integrating oncolytic viruses in combination cancer immunotherapy

Bommareddy, P. K., Shettigar, M., & Kaufman, H. L. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0014-6 · Cited by 704 · see citing works

New horizons in tumor microenvironment biology: challenges and opportunities

Chen, F., Zhuang, X., Lin, L., Yu, P., Wang, Y., Shi, Y., Hu, G., & Sun, Y. (2015) · BMC Medicine · doi:10.1186/s12916-015-0278-7 · Cited by 704 · see citing works

The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment

Monteran, L., & Erez, N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01835 · Cited by 675 · see citing works

Macrophage polarization in pathology

Sica, A., Erreni, M., Allavena, P., & Porta, C. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1995-y · Cited by 673 · see citing works

Tumour heterogeneity and metastasis at single-cell resolution

Lawson, D. A., Kessenbrock, K., Davis, R. T., Pervolarakis, N., & Werb, Z. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0236-7 · Cited by 606 · see citing works

The extracellular matrix in tumor progression and metastasis

Eble, J. A., & Niland, S. (2019) · Clinical & Experimental Metastasis · doi:10.1007/s10585-019-09966-1 · Cited by 613 · see citing works

Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor inhibiting HIF-1

Umezu, T., Tadokoro, H., Azuma, K., Yoshizawa, S., Ohyashiki, K., & Ohyashiki, J. H. (2014) · Blood · doi:10.1182/blood-2014-05-576116 · Cited by 600 · see citing works

CAR T cells in solid tumors: challenges and opportunities

Marofi, F., Motavalli, R., Safonov, V. A., Thangavelu, L., Yumashev, A. V., Alexander, M., Shomali, N., Chartrand, M. S., Pathak, Y., Jarahian, M., et al. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-02128-1 · Cited by 582 · see citing works

Sympathetic nervous system regulation of the tumour microenvironment

Cole, S. W., Nagaraja, A. S., Lutgendorf, S. K., Green, P. A., & Sood, A. K. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3978 · Cited by 576 · see citing works

The obese adipose tissue microenvironment in cancer development and progression

Quail, D. F., & Dannenberg, A. J. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0126-x · Cited by 542 · see citing works

Macrophage Polarization in Chronic Inflammatory Diseases: Killers or Builders?

Parisi, L., Gini, E., Baci, D., Tremolati, M., Fanuli, M., Bassani, B., Farronato, G., Bruno, A., & Mortara, L. (2018) · Journal of Immunology Research · doi:10.1155/2018/8917804 · Cited by 508 · see citing works

Genetically engineered mouse models in oncology research and cancer medicine

Kersten, K., de Visser, K. E., van Miltenburg, M. H., & Jonkers, J. (2017) · EMBO Molecular Medicine · doi:10.15252/emmm.201606857 · Cited by 502 · see citing works

Control of tumor-associated macrophages and T cells in glioblastoma via AHR and CD39

Takenaka, M. C., Gabriely, G., Rothhammer, V., Mascanfroni, I. D., Wheeler, M. A., Chao, C.-C., Gutiérrez-Vázquez, C., Kenison, J., Tjon, E. C., Barroso, A., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-019-0370-y · Cited by 517 · see citing works

Single-cell analysis tools for drug discovery and development

Heath, J. R., Ribas, A., & Mischel, P. S. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.16 · Cited by 473 · see citing works

The role of tumor-associated macrophages (TAMs) in tumor progression and relevant advance in targeted therapy

Yang, Q., Guo, N., Zhou, Y., Chen, J., Wei, Q., & Han, M. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.04.004 · Cited by 471 · see citing works

Three-Dimensional Spheroids as In Vitro Preclinical Models for Cancer Research

Pinto, B., Henriques, A. C., Silva, P. M. A., & Bousbaa, H. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12121186 · Cited by 440 · see citing works

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis

Nielsen, S. R., Quaranta, V., Linford, A., Emeagi, P., Rainer, C., Santos, A., Ireland, L., Sakai, T., Sakai, K., Kim, Y.-S., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3340 · Cited by 441 · see citing works

Exosomes in the tumor microenvironment as mediators of cancer therapy resistance

Li, I., & Nabet, B. Y. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0975-5 · Cited by 416 · see citing works

Prognostic value of preoperative systemic immune-inflammation index in patients with cervical cancer

Huang, H., Liu, Q., Zhu, L., Zhang, Y., Lu, X., Wu, Y., & Liu, L. (2019) · Scientific Reports · doi:10.1038/s41598-019-39150-0 · Cited by 408 · see citing works

Il-23 secreted by myeloid cells drives castration-resistant prostate cancer

Calcinotto, A., Spataro, C., Zagato, E., Di Mitri, D., Gil, V., Crespo, M., De Bernardis, G., Losa, M., Mirenda, M., Pasquini, E., et al. (2018) · Nature · doi:10.1038/s41586-018-0266-0 · Cited by 394 · see citing works

Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy

Bertero, T., Oldham, W. M., Grasset, E. M., Bourget, I., Boulter, E., Pisano, S., Hofman, P., Bellvert, F., Meneguzzi, G., Bulavin, D. V., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.09.012 · Cited by 393 · see citing works

On-chip human microvasculature assay for visualization and quantification of tumor cell extravasation dynamics

Chen, M. B., Whisler, J. A., Fröse, J., Yu, C., Shin, Y., & Kamm, R. D. (2017) · Nature Protocols · doi:10.1038/nprot.2017.018 · Cited by 385 · see citing works

Metastasis-Initiating Cells and Ecosystems

Massagué, J., & Ganesh, K. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0010 · Cited by 372 · see citing works

Complement Component 3 adapts the cerebrospinal fluid for leptomeningeal metastasis.

Boire, A., Zou, Y., Shieh, J., Macalinao, D. G., Pentsova, E., & Massagué, J. (2017) · Cell · doi:10.1016/j.cell.2017.02.025 · Cited by 366 · see citing works

Harnessing tumor‐associated macrophages as aids for cancer immunotherapy

Li, X., Liu, R., Su, X., Pan, Y., Han, X., Shao, C., & Shi, Y. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1102-3 · Cited by 364 · see citing works

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival

Kloepper, J., Riedemann, L., Amoozgar, Z., Seano, G., Susek, K., Yu, V., Dalvie, N., Amelung, R. L., Datta, M., Song, J. W., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525360113 · Cited by 357 · see citing works

Cancer associated fibroblasts: An essential role in the tumor microenvironment

Tao, L., Huang, G., Song, H., Chen, Y., & Chen, L. (2017) · Oncology Letters · doi:10.3892/ol.2017.6497 · Cited by 351 · see citing works

Comparison of immune infiltrates in melanoma and pancreatic cancer highlights VISTA as a potential target in pancreatic cancer

Blando, J., Sharma, A., Higa, M. G., Zhao, H., Vence, L., Yadav, S. S., Kim, J., Sepulveda, A. M., Sharp, M., Maitra, A., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811067116 · Cited by 334 · see citing works

Cancer-associated fibroblasts in tumor microenvironment–Accomplices in tumor malignancy

Liao, Z., Tan, Z. W., Zhu, P., & Tan, N. S. (2019) · Cellular Immunology · doi:10.1016/j.cellimm.2017.12.003 · Cited by 335 · see citing works

Tumor Microenvironment: Extracellular Matrix Alterations Influence Tumor Progression

Brassart-Pasco, S., Brézillon, S., Brassart, B., Ramont, L., Oudart, J.-B., & Monboisse, J. C. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00397 · Cited by 335 · see citing works

Tumor microenvironment differences between primary tumor and brain metastases

Cacho-Díaz, B., García-Botello, D. R., Wegman-Ostrosky, T., Reyes-Soto, G., Ortiz-Sánchez, E., & Herrera-Montalvo, L. A. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-019-02189-8 · Cited by 310 · see citing works

Hypoxia‐inducible factor‐1α/interleukin‐1β signaling enhances hepatoma epithelial–mesenchymal transition through macrophages in a hypoxic‐inflammatory microenvironment

Zhang, J., Zhang, Q., Lou, Y., Fu, Q., Chen, Q., Wei, T., Yang, J., Tang, J., Wang, J., Chen, Y., et al. (2018) · Hepatology · doi:10.1002/hep.29681 · Cited by 286 · see citing works

LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy

Pascual-García, M., Bonfill-Teixidor, E., Planas-Rigol, E., Rubio-Perez, C., Iurlaro, R., Arias, A., Cuartas, I., Sala-Hojman, A., Escudero, L., Martínez-Ricarte, F., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10369-9 · Cited by 262 · see citing works

Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF

Quail, D. F., Olson, O. C., Bhardwaj, P., Walsh, L. A., Akkari, L., Quick, M. L., Chen, I.-C., Wendel, N., Ben-Chetrit, N., Walker, J., et al. (2017) · Nature Cell Biology · doi:10.1038/ncb3578 · Cited by 277 · see citing works

SALMON: survival analysis learning with multi-omics neural networks on breast cancer

Huang, Z., Zhan, X., Xiang, S., Johnson, T. S., Helm, B., Yu, C. Y., Zhang, J., Salama, P., Rizkalla, M., Han, Z., et al. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00166 · Cited by 262 · see citing works

SHP2 inhibition diminishes KRASG12C cycling and promotes tumor microenvironment remodeling

Fedele, C., Li, S., Teng, K. W., Foster, C. J. R., Peng, D., Ran, H., Mita, P., Geer, M. J., Hattori, T., Koide, A., et al. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20201414 · Cited by 265 · see citing works

Molecular imaging of the tumor microenvironment

Zhou, Z., & Lu, Z.-R. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.07.012 · Cited by 253 · see citing works

Modeling tumor phenotypes in vitro with three-dimensional bioprinting

Langer, E. M., Allen-Petersen, B. L., King, S. M., Kendsersky, N. D., Turnidge, M. A., Kuziel, G. M., Riggers, R., Samatham, R., Amery, T. S., Jacques, S. L., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.090 · Cited by 256 · see citing works

Role of cancer‐associated fibroblast subpopulations in immune infiltration, as a new means of treatment in cancer

Mhaidly, R., & Mechta‐Grigoriou, F. (2021) · Immunological Reviews · doi:10.1111/imr.12978 · Cited by 231 · see citing works

Cell membrane coated-nanoparticles for cancer immunotherapy

Zeng, Y., Li, S., Zhang, S., Wang, L., Yuan, H., & Hu, F. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.02.023 · Cited by 238 · see citing works

3D-3-culture: a tool to unveil macrophage plasticity in the tumour microenvironment

Rebelo, S. P., Pinto, C., Martins, T. R., Harrer, N., Estrada, M. F., Loza-Alvarez, P., Cabeçadas, J., Alves, P. M., Gualda, E. J., Sommergruber, W., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.02.030 · Cited by 227 · see citing works

Bioresponsive Nanoparticles Targeted to Infectious Microenvironments for Sepsis Management

Zhang, C. Y., Gao, J., & Wang, Z. (2018) · Advanced Materials · doi:10.1002/adma.201803618 · Cited by 222 · see citing works

An Evolving story of the Metastatic Voyage of Ovarian Cancer Cells: Cellular and Molecular Orchestration of the Adipose-Rich Metastatic Microenvironment

Motohara, T., Masuda, K., Morotti, M., Zheng, Y., El-Sahhar, S., Chong, K. Y., Wietek, N., Alsaadi, A., Carrami, E. M., Hu, Z., et al. (2019) · Oncogene · doi:10.1038/s41388-018-0637-x · Cited by 218 · see citing works

Tumor microenvironment in ovarian cancer: function and therapeutic strategy

Yang, Y., Yang, Y., Yang, J., Zhao, X., & Wei, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00758 · Cited by 218 · see citing works

Long noncoding RNA CCAL transferred from fibroblasts by exosomes promotes chemoresistance of colorectal cancer cells

Deng, X., Ruan, H., Zhang, X., Xu, X., Zhu, Y., Peng, H., Zhang, X., Kong, F., & Guan, M. (2020) · International Journal of Cancer · doi:10.1002/ijc.32608 · Cited by 218 · see citing works

Tumour-on-a-chip: microfluidic models of tumour morphology, growth and microenvironment

Tsai, H.-F., Trubelja, A., Shen, A. Q., & Bao, G. (2017) · Journal of The Royal Society Interface · doi:10.1098/rsif.2017.0137 · Cited by 214 · see citing works

Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer

Takai, K., Le, A., Weaver, V. M., & Werb, Z. (2016) · Oncotarget · doi:10.18632/oncotarget.12658 · Cited by 207 · see citing works

Emerging Insights into Targeted Therapy-Tolerant Persister Cells in Cancer

Cabanos, H. F., & Hata, A. N. (2021) · Cancers · doi:10.3390/cancers13112666 · Cited by 189 · see citing works

Intermittent Hypoxia-induced Changes in Tumor-associated Macrophages and Tumor Malignancy in a Mouse Model of Sleep Apnea

Almendros, I., Wang, Y., Becker, L., Lennon, F. E., Zheng, J., Coats, B. R., Schoenfelt, K. S., Carreras, A., Hakim, F., Zhang, S. X., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201310-1830oc · Cited by 201 · see citing works

Endothelial-to-Mesenchymal Transition in Cancer

Clere, N., Renault, S., & Corre, I. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00747 · Cited by 199 · see citing works

Contribution of adipose tissue to development of cancer

Cozzo, A. J., Fuller, A. M., & Makowski, L. (2017) · Comprehensive Physiology · doi:10.1002/cphy.c170008 · Cited by 188 · see citing works

Applications of organoids for cancer biology and precision medicine

Lo, Y.-H., Karlsson, K., & Kuo, C. J. (2020) · Nature Cancer · doi:10.1038/s43018-020-0102-y · Cited by 182 · see citing works

Cancer Metastasis: The Role of the Extracellular Matrix and the Heparan Sulfate Proteoglycan Perlecan

Elgundi, Z., Papanicolaou, M., Major, G., Cox, T. R., Melrose, J., Whitelock, J. M., & Farrugia, B. L. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2019.01482 · Cited by 176 · see citing works

A landscape of metabolic variation across tumor types

Reznik, E., Luna, A., Aksoy, B. A., Liu, E. M., La, K., Ostrovnaya, I., Creighton, C. J., Hakimi, A. A., & Sander, C. (2018) · Cell Systems · doi:10.1016/j.cels.2017.12.014 · Cited by 172 · see citing works

Re-Education of Macrophages as a Therapeutic Strategy in Cancer

Kowal, J., Kornete, M., & Joyce, J. A. (2019) · Immunotherapy · doi:10.2217/imt-2018-0156 · Cited by 161 · see citing works

Inflammation-driven senescence-associated secretory phenotype in cancer-associated fibroblasts enhances peritoneal dissemination

Yasuda, T., Koiwa, M., Yonemura, A., Miyake, K., Kariya, R., Kubota, S., Yokomizo-Nakano, T., Yasuda-Yoshihara, N., Uchihara, T., Itoyama, R., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108779 · Cited by 165 · see citing works

Targeted depletion of tumour-associated macrophages by an alendronate–glucomannan conjugate for cancer immunotherapy

Zhan, X., Jia, L., Niu, Y., Qi, H., Chen, X., Zhang, Q., Zhang, J., Wang, Y., Dong, L., & Wang, C. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.09.007 · Cited by 161 · see citing works

3D Bioprinting of Breast Cancer Models for Drug Resistance Study

Wang, Y., Shi, W., Kuss, M., Mirza, S., Qi, D., Krasnoslobodtsev, A., Zeng, J., Band, H., Band, V., & Duan, B. (2018) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.8b01277 · Cited by 157 · see citing works

Targeting the tumor microenvironment: the protumor effects of IL-17 related to cancer type

Fabre, J., Giustiniani, J., Garbar, C., Antonicelli, F., Merrouche, Y., Bensussan, A., Bagot, M., & Al-Dacak, R. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17091433 · Cited by 159 · see citing works

Stromal cues regulate the pancreatic cancer epigenome and metabolome

Sherman, M. H., Yu, R. T., Tseng, T. W., Sousa, C. M., Liu, S., Truitt, M. L., He, N., Ding, N., Liddle, C., Atkins, A. R., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1620164114 · Cited by 147 · see citing works

3D bioprinting: improving<i>in vitro</i>models of metastasis with heterogeneous tumor microenvironments

Albritton, J. L., & Miller, J. S. (2017) · Disease Models &amp; Mechanisms · doi:10.1242/dmm.025049 · Cited by 154 · see citing works

Leveraging disulfiram to treat cancer: Mechanisms of action, delivery strategies, and treatment regimens

Lu, Y., Pan, Q., Gao, W., Pu, Y., Luo, K., He, B., & Gu, Z. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2021.121335 · Cited by 149 · see citing works

In Situ Self‐Assembled Nanofibers Precisely Target Cancer‐Associated Fibroblasts for Improved Tumor Imaging

Zhao, X., Li, L., Zhao, Y., An, H., Cai, Q., Lang, J., Han, X., Peng, B., Fei, Y., Liu, H., et al. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201908185 · Cited by 147 · see citing works

Novel research and future prospects of artificial intelligence in cancer diagnosis and treatment

Zhang, C., Xu, J., Tang, R., Yang, J., Wang, W., Yu, X., & Shi, S. (2023) · Journal of Hematology &amp; Oncology · doi:10.1186/s13045-023-01514-5 · Cited by 148 · see citing works

Regulation of tumor angiogenesis and mesenchymal–endothelial transition by p38α through TGF-β and JNK signaling

Batlle, R., Andrés, E., Gonzalez, L., Llonch, E., Igea, A., Gutierrez-Prat, N., Berenguer-Llergo, A., & Nebreda, A. R. (2019) · Nature Communications · doi:10.1038/s41467-019-10946-y · Cited by 142 · see citing works

Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model

Ayuso, J. M., Truttschel, R., Gong, M. M., Humayun, M., Virumbrales-Munoz, M., Vitek, R., Felder, M., Gillies, S. D., Sondel, P., Wisinski, K. B., et al. (2019) · OncoImmunology · doi:10.1080/2162402x.2018.1553477 · Cited by 142 · see citing works

Combination therapy with PD-1/PD-L1 blockade in non-small cell lung cancer: strategies and mechanisms

Huang, M.-Y., Jiang, X.-M., Wang, B.-L., Sun, Y., & Lu, J.-J. (2021) · Pharmacology &amp; Therapeutics · doi:10.1016/j.pharmthera.2020.107694 · Cited by 136 · see citing works

Development and characterization of a microfluidic model of the tumour microenvironment

Ayuso, J. M., Virumbrales-Muñoz, M., Lacueva, A., Lanuza, P. M., Checa-Chavarria, E., Botella, P., Fernández, E., Doblare, M., Allison, S. J., Phillips, R. M., et al. (2016) · Scientific Reports · doi:10.1038/srep36086 · Cited by 134 · see citing works

Biodegradable Microalgae-Based Carriers for Targeted Delivery and Imaging-Guided Therapy toward Lung Metastasis of Breast Cancer

Zhong, D., Zhang, D., Xie, T., & Zhou, M. (2020) · Small · doi:10.1002/smll.202000819 · Cited by 132 · see citing works

Impact of hypoxic tumor microenvironment and tumor cell plasticity on the expression of immune checkpoints

Lequeux, A., Noman, M. Z., Xiao, M., Sauvage, D., Van Moer, K., Viry, E., Bocci, I., Hasmim, M., Bosseler, M., Berchem, G., et al. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.05.021 · Cited by 117 · see citing works

Targeted destruction of cancer stem cells using multifunctional magnetic nanoparticles that enable combined hyperthermia and chemotherapy

Liu, D., Hong, Y., Li, Y., Hu, C., Yip, T.-C., Yu, W.-K., Zhu, Y., Fong, C.-C., Wang, W., Au, S.-K., et al. (2020) · Theranostics · doi:10.7150/thno.38989 · Cited by 125 · see citing works

Synthetic Immunology: Hacking Immune Cells to Expand Their Therapeutic Capabilities

Roybal, K. T., & Lim, W. A. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052302 · Cited by 124 · see citing works

Chemotherapy and tumor microenvironment of pancreatic cancer

Liu, Q., Liao, Q., & Zhao, Y. (2017) · Cancer Cell International · doi:10.1186/s12935-017-0437-3 · Cited by 120 · see citing works

Histomorphological stratification of stromal types associated with canine mammary tumours

Devi, S. S., George, A. J., Dhanushkrishna, B., et al. (2022) · Journal of Veterinary and Animal Sciences · doi:10.51966/jvas.2022.53.4.688-693 · Cited by 1 · see citing works

Molecular Aspects of Stromal-Parenchymal Interactions in Malignant Neoplasms

Zalatnai, A. (2006) · Current Molecular Medicine · doi:10.2174/156652406778195053 · Cited by 52 · see citing works

Experimental approaches to the study of cancer–stroma interactions: recent findings suggest a pivotal role for stroma in carcinogenesis

West, R. B., & van de Rijn, M. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700666 · Cited by 29 · see citing works

Stromal fibroblasts and invasive cancer growth

Петров, С. Б. (1988) · Kazan medical journal · doi:10.17816/kazmj98464

Tumour-Promoting Stromal Myofibroblasts in Human Carcinomas

Polanska, U. M., Mellody, K. T., & Orimo, A. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6615-5_16 · Cited by 6 · see citing works