The DOI matches its Crossref record; 166 of the 166 references it cites were found in a registry or an index.
Role of the NLRP3 inflammasome in cancer
Open accessAbstract
Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cleaving of the pro-inflammatory cytokines interleukin (IL)-1β and proIL-18 to produce active forms. The inflammasome complex consists of a Nod-like receptor (NLR), the adapter apoptosis-associated speck-like (ASC) protein, and Caspase-1. Dysregulation of NLRP3 inflammasome activation is involved tumor pathogenesis, although its role in cancer development and progression remains controversial due to the inconsistent findings described. In this review, we summarize the current knowledge on the contribution of the NLRP3 inflammasome on potential cancer promotion and therapy.
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Tumor biomarkers for diagnosis, prognosis and targeted therapy
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Metadata
- Authors
- Moossavi, M., Parsamanesh, N., Bahrami, A., Atkin, S. L., & Sahebkar, A.
- Venue
- Molecular Cancer
- Published
- 2018-11-17
- Volume
- 17
- Issue
- 1
- Pages
- 158-158
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W2901171191
- Cited by
- 417
- References
- 166
- FWCI
- 13.97
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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