The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Molecular characterization and clinical relevance of m6A regulators across 33 cancer types
Open accessAbstract
The methylation of N 6 adenosine (m 6 A) plays a critical role in diverse biological processes. However, knowledge regarding the reconstitution of m 6 A across cancer types is still lacking. Here, we systematically analyzed the molecular alterations and clinical relevance of m 6 A regulators across > 10,000 subjects representing 33 cancer types. We found that there are widespread genetic alterations to m 6 A regulators, and that their expression levels are significantly correlated with the activity of cancer hallmark-related pathways. Moreover, m 6 A regulators were found to be potentially useful for prognostic stratification, and we identified IGF2BP3 as a potential oncogene across multiple cancer types. Our results provide a valuable resource that will guide both mechanistic and therapeutic analyses of the role of m 6 A regulators in cancer.
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Cited by
Chen, Y., Zhao, Y., Chen, J., Peng, C., Zhang, Y., Tong, R., Cheng, Q., Yang, B., Feng, X., Lu, Y., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01239-w · Cited by 284
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Metadata
- Authors
- Li, Y., Xiao, J., Bai, J., Tian, Y., Qu, Y., Chen, X., Wang, Q., Li, X., Zhang, Y., & Xu, J.
- Venue
- Molecular Cancer
- Published
- 2019-09-14
- Volume
- 18
- Issue
- 1
- Pages
- 137-137
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W2972917142
- Cited by
- 398
- References
- 10
- FWCI
- 17.47
- Type
- journal article
- Language
- en
- Open access
- gold
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- Li, Y., Xiao, J., Bai, J., Tian, Y., Qu, Y., Chen, X., Wang, Q., Li, X., Zhang, Y., & Xu, J. (2019). Molecular characterization and clinical relevance of m6A regulators across 33 cancer types. Molecular Cancer. https://doi.org/10.1186/s12943-019-1066-3
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