The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Novel insights on m6A RNA methylation in tumorigenesis: a double-edged sword
Open accessAbstract
N6-methyladenosine (m 6 A), the most prevalent modification of mammalian RNA, has received increasing attention. Although m 6 A has been shown to be associated with biological activities, such as spermatogenesis modulation, cell spermatogenesis and pluripotency, Drosophila sex determination, and the control of T cell homeostasis and response to heat shock, little is known about its roles in cancer biology and cancer stem cells. Recent articles have noted that some genes have abnormal m 6 A expression after tumorigenesis, including genes ABS2, RARA, MYB, MYC, ADAM19 and FOX1 . Abnormal changes in the m 6 A levels of these genes are closely related to tumour occurrence and development. In this review, we summarized the ‘dual edge weapon’ role of RNA methylation in the tumorigenesis. We discussed RNA methylation could lead to not only tumour progression but also tumour suppression. Moreover, we clarified that the abnormal changes in the m 6 A enrichment of specific loci contribute to tumour occurrence and development, thereby representing a novel anti-cancer strategy by restoration to balanced RNA methylation in tumour cells.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
N6-methyladenosine-dependent regulation of messenger RNA stability
Wang, X., Lu, Z., Gomez, A., Hon, G. C., Yue, Y., Han, D., Fu, Y., Parisien, M., Dai, Q., Jia, G., et al. (2014) · Nature · doi:10.1038/nature12730 · Cited by 4,558
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
Jia, G., Fu, Y., Zhao, X., Dai, Q., Zheng, G., Yang, Y., Yi, C., Lindahl, T., Pan, T., Yang, Y.-G., et al. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.687 · Cited by 4,106 · cited 14×
“Furthermore, it has been reported that the presence of increased METTL3 levels in AML leads to higher m6A methylation levels of BCL2 and PTEN and promotes the translation of BCL2 and PTEN mRNA, which ultimately leads to tumour formation [50].”
BackgroundInfluentialALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
Zheng, G., Dahl, J. A., Niu, Y., Fedorcsak, P., Huang, C.-M., Li, C. J., Vågbø, C. B., Shi, Y., Wang, W.-L., Song, S.-H., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.015 · Cited by 3,550
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
Wang, X., Zhao, B. S., Roundtree, I. A., Lu, Z., Han, D., Ma, H., Weng, X., Chen, K., Shi, H., & He, C. (2015) · Cell · doi:10.1016/j.cell.2015.05.014 · Cited by 3,483
A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
Liu, J., Yue, Y., Han, D., Wang, X., Fu, Y., Zhang, L., Jia, G., Yu, M., Lu, Z., Deng, X., et al. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1432 · Cited by 3,433
Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation
Huang, H., Weng, H., Sun, W., Qin, X., Shi, H., Wu, H., Zhao, B. S., Mesquita, A., Liu, C., Yuan, C. L., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0045-z · Cited by 2,997
Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing
Xiao, W., Adhikari, S., Dahal, U., Chen, Y.-S., Hao, Y.-J., Sun, B.-F., Sun, H.-Y., Li, A., Ping, X.-L., Lai, W.-Y., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.01.012 · Cited by 2,054
HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events
Alarcón, C. R., Goodarzi, H., Lee, H., Liu, X., Tavazoie, S., & Tavazoie, S. F. (2015) · Cell · doi:10.1016/j.cell.2015.08.011 · Cited by 1,514
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling
Su, R., Dong, L., Li, C., Nachtergaele, S., Wunderlich, M., Qing, Y., Deng, X., Wang, Y., Weng, X., Hu, C., et al. (2018) · Cell · doi:10.1016/j.cell.2017.11.031 · Cited by 1,137
Cited by
The role of m6A RNA methylation in cancer
Sun, T., Wu, R., & Ming, L. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108613 · Cited by 963
Yu, J., Chai, P., Xie, M., Ge, S., Ruan, J., Fan, X., & Jia, R. (2021) · Genome Biology · doi:10.1186/s13059-021-02308-z · Cited by 940
Self-citationChen, Y., Peng, C., Chen, J., Chen, D., Yang, B., He, B., Hu, W., Zhang, Y., Liu, H., Dai, L., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1053-8 · Cited by 630
Molecular characterization and clinical relevance of m6A regulators across 33 cancer types
Li, Y., Xiao, J., Bai, J., Tian, Y., Qu, Y., Chen, X., Wang, Q., Li, X., Zhang, Y., & Xu, J. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1066-3 · Cited by 398
The role of N6-methyladenosine (m6A) modification in the regulation of circRNAs
Zhang, L., Hou, C., Chen, C., Guo, Y., Yuan, W., Yin, D., Liu, J., & Sun, Z. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01224-3 · Cited by 331
Metadata
- Authors
- Wang, S., Chai, P., Jia, R., & Jia, R.
- Venue
- Molecular Cancer
- Published
- 2018-07-21
- Volume
- 17
- Issue
- 1
- Pages
- 101-101
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W2883872430
- Cited by
- 239
- References
- 9
- FWCI
- 12.01
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Novel insights on m6A RNA methylation in tumorigenesis: a double-edged sword. https://app.cochat.ai/papers/10.1186/s12943-018-0847-4
- The paper
- Wang, S., Chai, P., Jia, R., & Jia, R. (2018). Novel insights on m6A RNA methylation in tumorigenesis: a double-edged sword. Molecular Cancer. https://doi.org/10.1186/s12943-018-0847-4
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
