The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells
Open accessAbstract
Background: Lung cancer has high morbidity and mortality worldwide with non-small cell lung cancer (NSCLC) accounting for 85% of the cases. Therapies for lung cancer have relatively poor outcomes and further improvements are required. Circular RNAs have been reported to participate in the occurrence and progression of cancer. Information on the functions and mechanism of circRNAs in lung cancer is limited and needs more exploration. Methods: We detected expression of genes and proteins by qPCR and western blot. Function of circSATB2 was investigated using RNA interference and overexpression assays. Location of circSATB2 was assessed by fluorescence in situ hybridization (FISH). Interaction of circSATB2, miR-326 and FSCN1 was confirmed by dual-luciferase reporter assay. Results: Data from the investigation showed that circSATB2 was highly expressed in NSCLC cells and tissues. circSATB2 positively regulated fascin homolog 1, actin-bundling protein 1 (FSCN1) expression via miR-326 in lung cancer cells. Furthermore, circSATB2 can be transferred by exosomes and promote the proliferation, migration and invasion of NSCLC cells, as well as induce abnormal proliferation in normal human bronchial epithelial cells. Also, circSATB2 was highly expressed in serumal exosomes from lung cancer patients with high sensitivity and specificity for clinical detection and was related to lung cancer metastasis. Conclusions: circSATB2 participated in the progression of NSCLC and was differentially expressed in lung cancer tissue and serumal exosomes. circSATB2 may be potential biomarker for the diagnosis of NSCLC.
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2 retracted
Zhang, H., Deng, T., Ge, S., Liu, Y., Bai, M., Zhu, K., Fan, Q., Li, J., Ning, T., Tian, F., et al. (2019) · Oncogene · doi:10.1038/s41388-018-0619-z · Cited by 303
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Cancer statistics in China, 2015
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Siegel, R. L., Miller, K. D., & Jemal, A. (2016) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21332 · Cited by 16,003
Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990
Natural RNA circles function as efficient microRNA sponges
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Circular RNAs are abundant, conserved, and associated with ALU repeats
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circRNA biogenesis competes with pre-mRNA splicing
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Cited by
Xu, Z., Chen, Y., Ma, L., Chen, Y., Liu, J., Guo, Y., Yu, T., Zhang, L., Zhu, L., & Shu, Y. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.01.046 · Cited by 319
Li, M.-Y., Liu, L.-Z., & Dong, M. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01312-y · Cited by 215
Metadata
- Authors
- Zhang, N., Nan, A., Chen, L., Li, X., Jia, Y., Qiu, M., Dai, X., Zhou, H., Zhu, J., Zhang, H., & Jiang, Y.
- Venue
- Molecular Cancer
- Published
- 2020-06-03
- Volume
- 19
- Issue
- 1
- Pages
- 101-101
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W3032454669
- Cited by
- 322
- References
- 42
- FWCI
- 14.94
- Type
- journal article
- Language
- en
- Open access
- gold
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