The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Retracted: Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR‐133/PRDM16 pathway
Open accessAbstract
Cancer‐related cachexia is a metabolic syndrome characterized by a wasting disorder of adipose and skeletal muscle and is accompanied by body weight loss and systemic inflammation. The treatment options for cancer cachexia are limited, and the molecular mechanism remains poorly understood. Circular RNAs (circRNAs) are a novel family of endogenous noncoding RNAs that have been proposed to regulate gene expression in mammals. Exosomes are small vesicles derived from cells, and recent studies have shown that circRNAs are stable in exosomes. However, little is known about the biological role of circRNAs in exosomes. In our study, we showed that circRNAs in plasma exosomes have specific expression features in gastric cancer (GC), and ciRS‐133 is linked with the browning of white adipose tissue (WAT) in GC patients. Exosomes derived from GC cells deliver ciRS‐133 into preadipocytes, promoting the differentiation of preadipocytes into brown‐like cells by activating PRDM16 and suppressing miR‐133. Moreover, knockdown of ciRS‐133 reduced cancer cachexia in tumor‐implanted mice, decreasing oxygen consumption and heat production. Thus, exosome‐delivered circRNAs are involved in WAT browning and play a key role in cancer‐associated cachexia.
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Cites
Natural RNA circles function as efficient microRNA sponges
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Cold-Activated Brown Adipose Tissue in Healthy Men
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BackgroundAdipose-derived circulating miRNAs regulate gene expression in other tissues
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Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90
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Cited by
RNA delivery by extracellular vesicles in mammalian cells and its applications
O’Brien, K., Breyne, K., Ughetto, S., Laurent, L. C., & Breakefield, X. O. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0251-y · Cited by 1,811
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Self-citationCancer-associated adipocytes: key players in breast cancer progression
Wu, Q., Li, B., Li, Z., Li, J., Sun, S., & Sun, S. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0778-6 · Cited by 462
Self-citationCircular RNA circSATB2 promotes progression of non-small cell lung cancer cells
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Metadata
- Authors
- Zhang, H., Zhu, L., Bai, M., Liu, Y., Zhan, Y., Deng, T., Yang, H., Sun, W., Wang, X., Zhu, K., Fan, Q., Li, J., Ying, G., & Ba, Y.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2019-01-04
- Volume
- 144
- Issue
- 10
- Pages
- 2501-2515
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2899615662
- Cited by
- 210
- References
- 11
- FWCI
- 10.67
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- bronze
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- Zhang, H., Zhu, L., Bai, M., Liu, Y., Zhan, Y., Deng, T., Yang, H., Sun, W., Wang, X., Zhu, K., Fan, Q., Li, J., Ying, G., & Ba, Y. (2019). Retracted: Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR‐133/PRDM16 pathway. International Journal of Cancer. https://doi.org/10.1002/ijc.31977
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