The DOI matches its Crossref record; 291 of the 291 references it cites were found in a registry or an index.
The role of ubiquitination and deubiquitination in cancer metabolism
Open accessAbstract
Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of cancer, sustaining cancer cell growth. Multiple signaling pathways, transcription factors and metabolic enzymes participate in the modulation of cancer metabolism and thus, metabolic reprogramming is a highly complex process. Recent studies have observed that ubiquitination and deubiquitination are involved in the regulation of metabolic reprogramming in cancer cells. As one of the most important type of post-translational modifications, ubiquitination is a multistep enzymatic process, involved in diverse cellular biological activities. Dysregulation of ubiquitination and deubiquitination contributes to various disease, including cancer. Here, we discuss the role of ubiquitination and deubiquitination in the regulation of cancer metabolism, which is aimed at highlighting the importance of this post-translational modification in metabolic reprogramming and supporting the development of new therapeutic approaches for cancer treatment.
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2 retracted
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Cited by
Wang, X., Li, Y., He, M., Kong, X., Jiang, P., Liu, X., Diao, L., Zhang, X., Li, H., Ling, X., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkab962 · Cited by 260
Self-citationKim, M.-J., Choi, B., Kim, J. Y., Min, Y., Kwon, D. H., Son, J., Lee, J. S., Lee, J. S., Chun, E., & Lee, K.-Y. (2022) · Translational Oncology · doi:10.1016/j.tranon.2021.101250 · Cited by 28
Targeted protein modification as a paradigm shift in drug discovery
Amirian, R., Azadi Badrbani, M., Izadi, Z., Samadian, H., Bahrami, G., Sarvari, S., Abdolmaleki, S., Nabavi, S. M., Derakhshankhah, H., & Jaymand, M. (2023) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2023.115765 · Cited by 18
Metadata
- Authors
- Sun, T., Liu, Z., & Yang, Q.
- Venue
- Molecular Cancer
- Published
- 2020-10-01
- Volume
- 19
- Issue
- 1
- Pages
- 146-146
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W3091696541
- Cited by
- 508
- References
- 291
- FWCI
- 14.45
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
