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USP8 regulates liver cancer progression via the inhibition of TRAF6-mediated signal for NF-κB activation and autophagy induction by TLR4
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USP8 negatively regulates autophagy by deubiquitinating the autophagy factors TRAF6, BECN1 and p62.
“More recently, it was reported that USP8 negatively regulates autophagy by deubiquitinating the autophagy factors TRAF6, BECN1 and p62 [16], supporting the hypothesis that USP8 reduction can be used to promote autophagy.”
From USP8 Down-Regulation Promotes Parkin-Independent Mitophagy in the Drosophila Brain and in Human Neurons (2023) · cites this paper as [16]
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Cites
NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma
Luedde, T., & Schwabe, R. F. (2011) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.213 · Cited by 1,345
The increasing complexity of the ubiquitin code
Yau, R., & Rape, M. (2016) · Nature Cell Biology · doi:10.1038/ncb3358 · Cited by 1,054
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Cited by
Sorted by citations
Mauri, S., Bernardo, G., Martinez, A., Favaro, M., Trevisan, M., Cobraiville, G., Fillet, M., Caicci, F., Whitworth, A. J., & Ziviani, E. (2023) · Cells · doi:10.3390/cells12081143 · Cited by 19
Metadata
- Authors
- Kim, M.-J., Choi, B., Kim, J. Y., Min, Y., Kwon, D. H., Son, J., Lee, J. S., Lee, J. S., Chun, E., & Lee, K.-Y.
- Venue
- Translational Oncology
- Publisher
- Elsevier BV
- Published
- 2022-01
- Volume
- 15
- Issue
- 1
- Pages
- 101250
- ISSN
- 1936-5233
- PMC
- PMC8546492
- Cited by
- 28
- References
- 2
- Language
- en
- Licence
- Funders
- National Research Foundation of Korea (NRF-2021R1A2C1094478, NRF-2021R1F1A1049324)
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