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Cited by 28Ovarian function and disordersReproductive Health and TechnologiesDiabetes, Cardiovascular Risks, and Lipoproteins

Association between indicators of visceral lipid accumulation and infertility: a cross-sectional study based on U.S. women

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Deng, Chenyuan, Ke, Xinpeng, Lin, Liangcai, Fan, Yong, Li, Chaohui·2024·Lipids in Health and Disease
DOI 10.1186/s12944-024-02178-xPMC PMC11170861
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Abstract

Background: Evidence on the association between visceral lipid accumulation and infertility remains limited and controversial. Therefore, the current investigation is the first investigation to unveil this correlation by utilizing novel indicators of visceral lipid accumulation. Methods: The present study utilized the NHANES 2013–2020 dataset. Researchers utilized multiple logistic regression, smoothed curve fitting, and subgroup analysis to investigate the associations of waist circumference (WC), metabolic score for visceral fat (METS-VF), lipid accumulation product (LAP), visceral adiposity index (VAI) with infertility. Additionally, the eXtreme Gradient Boosting (XGBoost) algorithm model was utilized to evaluate the relative importance of the factors. Results: After adjusting for potential factors that could influence the results, researchers discovered that all these four indicators of visceral lipid accumulation exhibited strong positive correlations with the probability of infertility. The subgroup analysis demonstrated that the correlations remained consistent in the majority of subgroups (P for interaction > 0.05). The results of XGBoost algorithm model indicate that METS-VF is the most meaningful factor in infertility. The ROC curve research revealed that while METS-VF had the greatest AUC values, there was no variation in the AUC value of different markers of visceral fat accumulation (P > 0.05). Conclusions: The present investigation discovered that increased WC, METS-VF, LAP, and VAI were associated with a heightened prevalence of infertility.

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Sorted by citations

Authors
Deng, C., Ke, X., Lin, L., Fan, Y., & Li, C.
Affiliations
Third Affiliated Hospital of Guangzhou Medical University (CN)
Corresponding author
  • Fan, Yong
  • Li, Chaohui
ORCID
Venue
Lipids in Health and Disease
Publisher
Springer Science and Business Media LLC
Published
2024-06-13
Volume
23
Issue
1
Pages
186-186
ISSN
1476-511X (ISSN-L)
DOI
10.1186/s12944-024-02178-x
PMC
PMC11170861
OpenAlex
W4399647328
Cited by
28
References
1
Citations by year
2026: 4 · 2025: 15 · 2024: 9
FWCI
10.98
Type
journal article
Language
en
Open access
Licence
Locations
  • Lipids in Health and Disease (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Guangzhou Science and technology planning project (2023A03J0377, 2023A03J0043)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
infertility, visceral fat, waist circumference, metabolic score for visceral fat, lipid accumulation product, visceral adiposity index, women's reproductive health, abdominal obesity
MeSH terms
Adult, Cross-Sectional Studies, Female, Humans, Infertility, Infertility, Female, Middle Aged, Nutrition Surveys, ROC Curve, United States, Metabolic Syndrome, Intra-Abdominal Fat, Adiposity, Lipid Metabolism, Waist Circumference

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