Obesity and hypertension
Abstract
Obesity and in particular the excessive visceral fat distribution is accompanied by several alterations at hormonal, inflammatory and endothelial level. These alterations induce a stimulation of several other mechanisms that contribute to the hypertensive state and on the other side to increase the cardiovascular morbidity. In these chapter we will examine the main mechanisms of obesity and obesity-related hypertension and in particular the role of sympathetic nervous system, the alterations of the renal function and at the microvascular level. We will also depict the role of insulin resistance as factor stimulating and potentiating the other mechanisms. The second part will be focalized on the major target organ damage linked with obesity and obesity-related hypertension. We will finally describe the management and treatment of obesity and the antihypertensive drug therapies more effective in hypertensive obeses.
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Diabetes, hypertension, cardiovascular/renal/hepatic complications, hypogonadotropic hypogonadism, bronchial asthma, and Alzheimer's disease are associated with obesity.
“Several comorbidities such as diabetes, hypertension, cardiovascular/renal/hepatic complications, hypogonadotropic hypogonadism, bronchial asthma, and Alzheimer’s disease are associated with obesity [10-13].”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [10]
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Roles of Amino Acid Derivatives in the Regulation of Obesity
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- Authors
- Seravalle, G., & Grassi, G.
- Affiliations
- IRCCS Istituto Auxologico Italiano (IT)
- University of Milano-Bicocca (IT)
- Corresponding author
- Seravalle, Gino
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 122
- Pages
- 1-7
- ISSN
- 1043-6618 (ISSN-L)
- OpenAlex
- W2614940508
- Cited by
- 909
- References
- 83
- Citations by year
- 2026: 74 · 2025: 129 · 2024: 127 · 2023: 138 · 2022: 125 · 2021: 143 · 2020: 105 · 2019: 40 · 2018: 18 · 2017: 5 · 2016: 3
- FWCI
- 6.42
- Type
- journal article
- Language
- en
- Update notices
- erratum (2017-10-01)
- Open access
- closed
- Locations
- Pharmacological Research (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- obesity, obesity-related hypertension, visceral fat, sympathetic nervous system, renal function, microvascular dysfunction, insulin resistance, target organ damage, antihypertensive therapy, cardiovascular morbidity
- MeSH terms
- Animals, Arteries, Diet Therapy, Heart, Humans, Hypertension, Hypoglycemic Agents, Life Style, Obesity, Anti-Obesity Agents, Bariatric Surgery
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