The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The effect of nanoparticle size on the probability to cross the blood-brain barrier: an in-vitro endothelial cell model
Open accessAbstract
BACKGROUND: During the last decade nanoparticles have gained attention as promising drug delivery agents that can transport through the blood brain barrier. Recently, several studies have demonstrated that specifically targeted nanoparticles which carry a large payload of therapeutic agents can effectively enhance therapeutic agent delivery to the brain. However, it is difficult to draw definite design principles across these studies, owing to the differences in material, size, shape and targeting agents of the nanoparticles. Therefore, the main objective of this study is to develop general design principles that link the size of the nanoparticle with the probability to cross the blood brain barrier. Specifically, we investigate the effect of the nanoparticle size on the probability of barbiturate coated GNPs to cross the blood brain barrier by using bEnd.3 brain endothelial cells as an in vitro blood brain barrier model. RESULTS: The results show that GNPs of size 70 nm are optimal for the maximum amount of gold within the brain cells, and that 20 nm GNPs are the optimal size for maximum free surface area. CONCLUSIONS: These findings can help understand the effect of particle size on the ability to cross the blood brain barrier through the endothelial cell model, and design nanoparticles for brain imaging/therapy contrast agents.
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Cites
Structure and function of the blood–brain barrier
Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.030 · Cited by 5,185
The blood-brain barrier: an engineering perspective
Wong, A. D., Ye, M., Levy, A. F., Rothstein, J. D., Bergles, D. E., & Searson, P. C. (2013) · Frontiers in Neuroengineering · doi:10.3389/fneng.2013.00007 · Cited by 662
Nanoparticle Technology for Drug Delivery Across the Blood-Brain Barrier
Lockman, P. R., Mumper, R. J., Khan, M. A., & Allen, D. D. (2002) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-120001481 · Cited by 592
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Metadata
- Authors
- Shilo, M., Sharon, A., Baranes, K., Motiei, M., Lellouche, J.-P. M., & Popovtzer, R.
- Venue
- Journal of Nanobiotechnology
- Published
- 2015-03-04
- Volume
- 13
- Issue
- 1
- Pages
- 19-19
- ISSN
- 1477-3155 (ISSN-L)
- OpenAlex
- W2144475530
- Cited by
- 237
- References
- 3
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- gold
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- Shilo, M., Sharon, A., Baranes, K., Motiei, M., Lellouche, J.-P. M., & Popovtzer, R. (2015). The effect of nanoparticle size on the probability to cross the blood-brain barrier: an in-vitro endothelial cell model. Journal of Nanobiotechnology. https://doi.org/10.1186/s12951-015-0075-7
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