Cited by 373Alzheimer's disease research and treatmentsNanoparticle-Based Drug DeliveryGold and Silver Nanoparticles Synthesis and Applications

Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease

Open access
Hou, Ke, Zhao, Jing, Wang, Hui, Li, Bin, Li, Kexin, Shi, Xinghua, Wan, Kaiwei, Ai, Jing +7 more·2020·Nature Communications

Abstract

Preventing aggregation of amyloid beta (Aβ) peptides is a promising strategy for the treatment of Alzheimer's disease (AD), and gold nanoparticles have previously been explored as a potential anti-Aβ therapeutics. Here we design and prepare 3.3 nm L- and D-glutathione stabilized gold nanoparticles (denoted as L3.3 and D3.3, respectively). Both chiral nanoparticles are able to inhibit aggregation of Aβ42 and cross the blood-brain barrier (BBB) following intravenous administration without noticeable toxicity. D3.3 possesses a larger binding affinity to Aβ42 and higher brain biodistribution compared with its enantiomer L3.3, giving rise to stronger inhibition of Aβ42 fibrillation and better rescue of behavioral impairments in AD model mice. This conjugation of a small nanoparticle with chiral recognition moiety provides a potential therapeutic approach for AD.

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  • D-GSH-stabilized gold nanoparticles at 3.3 nm possessed higher brain distribution compared to L-GSH-stabilized nanoparticles.

    “the D-GSH-stabilized gold nanoparticles at 3.3 nm (D3.3) possessed higher brain distribution compared to its enantiomer (L-GSH-stabilized nanoparticles, L3.3).”
  • D3.3 gold nanoparticles have a larger binding affinity towards amyloid-β than L3.3.

    “Together with a larger binding affinity towards amyloid-β of D3.3”

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Authors
Hou, K., Zhao, J., Wang, H., Li, B., Li, K., Shi, X., Wan, K., Ai, J., Lv, J., Wang, D., Huang, Q., Wang, H., Cao, Q., Liu, S., & Tang, Z.
Affiliations
  • Peking University (CN)
  • Harbin Institute of Technology (CN)
  • National Center for Nanoscience and Technology (CN)
  • Sun Yat-sen University (CN)
  • Harbin Medical University (CN)
  • Howard Hughes Medical Institute (US)
Corresponding author
  • Liu, Shaoqin
  • Tang, Zhiyong
Venue
Nature Communications
Published
2020-09-22
Volume
11
Issue
1
Pages
4790-4790
ISSN
2041-1723 (ISSN-L)
OpenAlex
W3088242221
Cited by
373
References
51
Citations by year
2026: 41 · 2025: 79 · 2024: 76 · 2023: 68 · 2022: 68 · 2021: 40 · 2020: 1
FWCI
26.62
Type
journal article
Language
en
Open access
Locations
  • Nature Communications (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Griffith Research Online (submittedVersion, cc-by)
Funders
  • Howard Hughes Medical Institute
  • National Natural Science Foundation of China (2014CB931801, 21890381, 21721002, 21721002 and 21475029, 21890381, QYZDJ-SSW-SLH038, 21721002, 21475029, 2016YFA0200700, 51825202)
  • Chinese Academy of Sciences (2016YFA0200700, QYZDJ‐SSW‐SLH038, 21721002)
  • Peking University
  • K. C. Wong Education Foundation
  • National Science Fund for Distinguished Young Scholars (51825202)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
Keywords
gold nanoparticles, chiral nanoparticles, Alzheimer's disease, amyloid-beta 42, amyloid aggregation inhibition, enantiomers, blood-brain barrier penetration, brain biodistribution, memory impairment, anti-amyloid therapy, nanoparticle drug delivery
MeSH terms
Alzheimer Disease, Animals, Blood-Brain Barrier, Brain, Cell Survival, Disease Models, Animal, Gold, Male, Memory Disorders, Mice, Inbred C57BL, Peptide Fragments, Stereoisomerism, Amyloid beta-Peptides, Mice, Metal Nanoparticles, Molecular Docking Simulation

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