Chiral gold nanoparticles enantioselectively rescue memory deficits in a mouse model of Alzheimer’s disease
Open accessAbstract
Preventing aggregation of amyloid beta (Aβ) peptides is a promising strategy for the treatment of Alzheimer's disease (AD), and gold nanoparticles have previously been explored as a potential anti-Aβ therapeutics. Here we design and prepare 3.3 nm L- and D-glutathione stabilized gold nanoparticles (denoted as L3.3 and D3.3, respectively). Both chiral nanoparticles are able to inhibit aggregation of Aβ42 and cross the blood-brain barrier (BBB) following intravenous administration without noticeable toxicity. D3.3 possesses a larger binding affinity to Aβ42 and higher brain biodistribution compared with its enantiomer L3.3, giving rise to stronger inhibition of Aβ42 fibrillation and better rescue of behavioral impairments in AD model mice. This conjugation of a small nanoparticle with chiral recognition moiety provides a potential therapeutic approach for AD.
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D-GSH-stabilized gold nanoparticles at 3.3 nm possessed higher brain distribution compared to L-GSH-stabilized nanoparticles.
“the D-GSH-stabilized gold nanoparticles at 3.3 nm (D3.3) possessed higher brain distribution compared to its enantiomer (L-GSH-stabilized nanoparticles, L3.3).”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [294]
D3.3 gold nanoparticles have a larger binding affinity towards amyloid-β than L3.3.
“Together with a larger binding affinity towards amyloid-β of D3.3”
From The blood–brain barrier: Structure, regulation and drug delivery (2023) · cites this paper as [294]
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Chiral‐Selective Antigen‐Presentation by Supramolecular Chiral Polymer Micelles
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Metal Nanoparticles in Alzheimer’s Disease
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Nanotechnology for the diagnosis and treatment of Alzheimer's disease: A bibliometric analysis
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Facet‐Dependent Biodegradable Mn3O4 Nanoparticles for Ameliorating Parkinson's Disease
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Chiral inorganic nanomaterials for biological applications
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Advances in Enantiomer-Dependent Nanotherapeutics
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Gold and silver nanoparticles in Alzheimer's and Parkinson's diagnostics and treatments
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Nanomedicines in the Management of Alzheimer’s Disease: Current View and Future Prospects
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Gold Nanoparticle-Based Therapy for Muscle Inflammation and Oxidative Stress
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Multifaceted nanoparticles: emerging mechanisms and therapies in neurodegenerative diseases
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Emerging nanotechnology for Alzheimer's disease: From detection to treatment
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Self-citationChirality Effects in Peptide Assembly Structures
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Advancements in the Application of Nanomedicine in Alzheimer’s Disease: A Therapeutic Perspective
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Medical importance and pharmacokinetics of gold nanoparticles in the human body
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Biological applications of chiral inorganic nanomaterials
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Recent progress of nanomedicine in the treatment of Alzheimer’s disease
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Neuromodulation by nanozymes and ultrasound during Alzheimer’s disease management
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Recent Progress in Nanomedicine for the Diagnosis and Treatment of Alzheimer’s Diseases
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Advanced Nanomedicines for Treating Refractory Inflammation-Related Diseases
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Chirality in peptide‐based materials: From chirality effects to potential applications
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Secreted endogenous macrosomes reduce Aβ burden and ameliorate Alzheimer’s disease
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Nanomaterials as Theranostic Agents for Cancer Therapy
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Expanding the Role of Chiral Drugs and Chiral Nanomaterials as a Potential Therapeutic Tool
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Chiral Engineered Biomaterials: New Frontiers in Cellular Fate Regulation for Regenerative Medicine
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Chiral Inorganic Nanomaterial‐Based Diagnosis and Treatments for Neurodegenerative Diseases
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Nanomedicines for Alzheimer's disease: Therapies based on pathological mechanisms
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Self-citationChiral AuCu heterostructures with site-specific geometric control and tailored plasmonic chirality
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Water-Induced Chiral Separation on a Au(111) Surface
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Inhibiting protein aggregation with nanomaterials: The underlying mechanisms and impact factors
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Exploiting mesoporous silica, silver and gold nanoparticles for neurodegenerative diseases treatment
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Interface Chirality: From Biological Effects to Biomedical Applications
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Glutathione: a naturally occurring tripeptide for functional metal nanomaterials
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- Authors
- Hou, K., Zhao, J., Wang, H., Li, B., Li, K., Shi, X., Wan, K., Ai, J., Lv, J., Wang, D., Huang, Q., Wang, H., Cao, Q., Liu, S., & Tang, Z.
- Affiliations
- Peking University (CN)
- Harbin Institute of Technology (CN)
- National Center for Nanoscience and Technology (CN)
- Sun Yat-sen University (CN)
- Harbin Medical University (CN)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Liu, Shaoqin
- Tang, Zhiyong
- ORCID
- Venue
- Nature Communications
- Published
- 2020-09-22
- Volume
- 11
- Issue
- 1
- Pages
- 4790-4790
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC7509831
- OpenAlex
- W3088242221
- Cited by
- 373
- References
- 51
- Citations by year
- 2026: 41 · 2025: 79 · 2024: 76 · 2023: 68 · 2022: 68 · 2021: 40 · 2020: 1
- FWCI
- 26.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Griffith Research Online (submittedVersion, cc-by)
- Funders
- Howard Hughes Medical Institute
- National Natural Science Foundation of China (2014CB931801, 21890381, 21721002, 21721002 and 21475029, 21890381, QYZDJ-SSW-SLH038, 21721002, 21475029, 2016YFA0200700, 51825202)
- Chinese Academy of Sciences (2016YFA0200700, QYZDJ‐SSW‐SLH038, 21721002)
- Peking University
- K. C. Wong Education Foundation
- National Science Fund for Distinguished Young Scholars (51825202)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Keywords
- gold nanoparticles, chiral nanoparticles, Alzheimer's disease, amyloid-beta 42, amyloid aggregation inhibition, enantiomers, blood-brain barrier penetration, brain biodistribution, memory impairment, anti-amyloid therapy, nanoparticle drug delivery
- MeSH terms
- Alzheimer Disease, Animals, Blood-Brain Barrier, Brain, Cell Survival, Disease Models, Animal, Gold, Male, Memory Disorders, Mice, Inbred C57BL, Peptide Fragments, Stereoisomerism, Amyloid beta-Peptides, Mice, Metal Nanoparticles, Molecular Docking Simulation
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