The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Metal nanoparticles: understanding the mechanisms behind antibacterial activity
Open accessAbstract
As the field of nanomedicine emerges, there is a lag in research surrounding the topic of nanoparticle (NP) toxicity, particularly concerned with mechanisms of action. The continuous emergence of bacterial resistance has challenged the research community to develop novel antibiotic agents. Metal NPs are among the most promising of these because show strong antibacterial activity. This review summarizes and discusses proposed mechanisms of antibacterial action of different metal NPs. These mechanisms of bacterial killing include the production of reactive oxygen species, cation release, biomolecule damages, ATP depletion, and membrane interaction. Finally, a comprehensive analysis of the effects of NPs on the regulation of genes and proteins (transcriptomic and proteomic) profiles is discussed.
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Kittler, S., Greulich, C., Diendorf, J., Köller, M., & Epple, M. (2010) · Chemistry of Materials · doi:10.1021/cm100023p · Cited by 1,126
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Shahbazi, M.-A., Faghfouri, L., Ferreira, M. P. A., Figueiredo, P., Maleki, H., Sefat, F., Hirvonen, J., & Santos, H. A. (2020) · Chemical Society Reviews · doi:10.1039/c9cs00283a · Cited by 523
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Huang, J., Liu, S., Zhang, C., Wang, X., Pu, J., Ba, F., Xue, S., Ye, H., Zhao, T., Li, K., et al. (2019) · Nature Chemical Biology · doi:10.1038/s41589-018-0169-2 · Cited by 312
Zhou, X., Wang, Z., Chan, Y. K., Yang, Y., Jiao, Z., Li, L., Li, J., Liang, K., & Deng, Y. (2022) · Advanced Functional Materials · doi:10.1002/adfm.202109469 · Cited by 150
Metadata
- Authors
- Slavin, Y. N., Asnis, J., Häfeli, U. O., & Bach, H.
- Venue
- Journal of Nanobiotechnology
- Published
- 2017-10-03
- Volume
- 15
- Issue
- 1
- Pages
- 65-65
- ISSN
- 1477-3155 (ISSN-L)
- OpenAlex
- W2760892774
- Cited by
- 2,571
- References
- 1
- FWCI
- 48.33
- Type
- journal article
- Language
- en
- Open access
- gold
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- Slavin, Y. N., Asnis, J., Häfeli, U. O., & Bach, H. (2017). Metal nanoparticles: understanding the mechanisms behind antibacterial activity. Journal of Nanobiotechnology. https://doi.org/10.1186/s12951-017-0308-z
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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