The DOI matches its Crossref record; 185 of the 185 references it cites were found in a registry or an index.
Polycystic ovary syndrome and mitochondrial dysfunction
Open accessAbstract
Polycystic ovary syndrome (PCOS) is a prevalent hormonal disorder of premenopausal women worldwide and is characterized by reproductive, endocrine, and metabolic abnormalities. The clinical manifestations of PCOS include oligomenorrhea or amenorrhea, hyperandrogenism, ovarian polycystic changes, and infertility. Women with PCOS are at an increased risk of suffering from type 2 diabetes; me\tabolic syndrome; cardiovascular events, such as hypertension, dyslipidemia; gynecological diseases, including infertility, endometrial dysplasia, endometrial cancer, and ovarian malignant tumors; pregnancy complications, such as premature birth, low birthweight, and eclampsia; and emotional and mental disorders in the future. Although numerous studies have focused on PCOS, the underlying pathophysiological mechanisms of this disease remain unclear. Mitochondria play a key role in energy production, and mitochondrial dysfunction at the cellular level can affect systemic metabolic balance. The recent wide acceptance of functional mitochondrial disorders as a correlated factor of numerous diseases has led to the presupposition that abnormal mitochondrial metabolic markers are associated with PCOS. Studies conducted in the past few years have confirmed that increased oxidative stress is associated with the progression and related complications of PCOS and have proven the relationship between other mitochondrial dysfunctions and PCOS. Thus, this review aims to summarize and discuss previous and recent findings concerning the relationship between mitochondrial dysfunction and PCOS.
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Cited by
Chronic Low Grade Inflammation in Pathogenesis of PCOS
Rudnicka, E., Suchta, K., Grymowicz, M., Calik-Ksepka, A., Smolarczyk, K., Duszewska, A. M., Smolarczyk, R., & Meczekalski, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073789 · Cited by 680
Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites
Chen, W., & Pang, Y. (2021) · Metabolites · doi:10.3390/metabo11120869 · Cited by 228
The interplay between androgens and the immune response in polycystic ovary syndrome
Shabbir, S., Khurram, E., Moorthi, V. S., Eissa, Y. T. H., Kamal, M. A., & Butler, A. E. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04116-4 · Cited by 108
Do GLP-1 Analogs Have a Place in the Treatment of PCOS? New Insights and Promising Therapies
Szczesnowicz, A., Szeliga, A., Niwczyk, O., Bala, G., & Meczekalski, B. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12185915 · Cited by 83
Mei, S., Ding, J., Wang, K., Ni, Z., & Yu, J. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.876620 · Cited by 75
Metadata
- Authors
- Zhang, J., Bao, Y., Zhou, X., & Zheng, L.
- Venue
- Reproductive Biology and Endocrinology
- Published
- 2019-08-16
- Volume
- 17
- Issue
- 1
- Pages
- 67-67
- ISSN
- 1477-7827 (ISSN-L)
- OpenAlex
- W2966981559
- Cited by
- 258
- References
- 185
- FWCI
- 16.52
- Type
- journal article
- Language
- en
- Open access
- gold
- Licence
- creativecommons.org/licenses/by/4.0/ (tdm)
- creativecommons.org/licenses/by/4.0/ (vor)
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