Increased oxidative stress in obesity and its impact on metabolic syndrome
Open accessAbstract
Obesity is a principal causative factor in the development of metabolic syndrome. Here we report that increased oxidative stress in accumulated fat is an important pathogenic mechanism of obesity-associated metabolic syndrome. Fat accumulation correlated with systemic oxidative stress in humans and mice. Production of ROS increased selectively in adipose tissue of obese mice, accompanied by augmented expression of NADPH oxidase and decreased expression of antioxidative enzymes. In cultured adipocytes, elevated levels of fatty acids increased oxidative stress via NADPH oxidase activation, and oxidative stress caused dysregulated production of adipocytokines (fat-derived hormones), including adiponectin, plasminogen activator inhibitor-1, IL-6, and monocyte chemotactic protein-1. Finally, in obese mice, treatment with NADPH oxidase inhibitor reduced ROS production in adipose tissue, attenuated the dysregulation of adipocytokines, and improved diabetes, hyperlipidemia, and hepatic steatosis. Collectively, our results suggest that increased oxidative stress in accumulated fat is an early instigator of metabolic syndrome and that the redox state in adipose tissue is a potentially useful therapeutic target for obesity-associated metabolic syndrome.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Obesity is associated with systemic oxidative stress, which promotes insulin resistance.
“Obesity is associated with systemic oxidative stress (43, 44), which promotes insulin resistance (11–18).”
From Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance (2021) · cites this paper as [43]
By suppressing adipocyte oxidative stress, spirulina may lead to systemic anti-inflammatory and insulin-sensitising effects.
“Thus, by suppressing adipocyte oxidative stress, spirulina may lead to systemic anti-inflammatory and insulin-sensitising effects.12–20”
From Effects of spirulina on weight loss and blood lipids: A review (2020) · cites this paper as [16]
ROS and RNS produced by immune cells are suggested to contribute to oxidative damage in obese adipose tissue.
“It has been suggested that the production of ROS and RNS by immune cells contribute to the oxidative damage observed in obese AT (74,75).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [74]
Increased oxidative stress and reduced antioxidant defense have been demonstrated in obese adipose tissue.
“Increased oxidative stress and reduced antioxidant defense have been demonstrated in obese AT (74).”
From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [74]
High levels of ROS and systemic oxidative stress have been associated with obesity and insulin resistance.
“High levels of ROS and systemic oxidative stress have been associated with obesity and insulin resistance ([45](#B45)).”
From Mitochondrial fatty acid oxidation in obesity (2013) · cites this paper as [45]
The AGE-RAGE axis triggers oxidative stress, which is associated with the development of insulin resistance.
“In addition to inflammation, the AGE-RAGE axis also triggers oxidative stress, which is associated with the development of insulin resistance.[122,123]”
From The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction (2021) · cites this paper as [122]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
Biochemistry and molecular cell biology of diabetic complications
Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518 · see citing works
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works
Ford, E. S., Giles, W. H., & Dietz, W. H. (2002) · JAMA · doi:10.1001/jama.287.3.356 · Cited by 6,698 · see citing works
Grundy, S. M., Brewer, H. B., Cleeman, J. I., Smith, S. C., & Lenfant, C. (2004) · Circulation · doi:10.1161/01.cir.0000111245.75752.c6 · Cited by 5,982 · see citing works
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405 · see citing works
Insulin signalling and the regulation of glucose and lipid metabolism
Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., et al. (2001) · Nature Medicine · doi:10.1038/90984 · Cited by 4,915 · see citing works
Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity
Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856 · see citing works
Self-citationCardiovascular Morbidity and Mortality Associated With the Metabolic Syndrome
Isomaa, B., Almgren, P., Tuomi, T., Forsén, B., Lahti, K., Nissén, M., Taskinen, M.-R., & Groop, L. (2001) · Diabetes Care · doi:10.2337/diacare.24.4.683 · Cited by 4,760 · see citing works
The hormone resistin links obesity to diabetes
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., & Lazar, M. A. (2001) · Nature · doi:10.1038/35053000 · Cited by 4,755 · see citing works
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277 · see citing works
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837 · see citing works
Obesity and insulin resistance
Kahn, B. B., & Flier, J. S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10842 · Cited by 3,283 · see citing works
Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061 · see citing works
NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886 · see citing works
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., & Scherer, P. E. (2001) · Nature Medicine · doi:10.1038/90992 · Cited by 2,526 · see citing works
Obesity and the regulation of energy balance
Spiegelman, B. M., & Flier, J. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00240-9 · Cited by 2,398 · see citing works
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234 · see citing works
Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes
Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232 · see citing works
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
Maeda, N., Shimomura, I., Kishida, K., Nishizawa, H., Matsuda, M., Nagaretani, H., Furuyama, N., Kondo, H., Takahashi, M., Arita, Y., et al. (2002) · Nature Medicine · doi:10.1038/nm724 · Cited by 2,074 · see citing works
Self-citationFruebis, J., Tsao, T., Javorschi, S., Ebbets-Reed, D., Erickson, M., Yen, F. T., Bihain, B. E., & Lodish, H. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.2005 · Cited by 1,987 · see citing works
Hypercholesterolemia increases endothelial superoxide anion production.
Ohara, Y., Peterson, T. E., & Harrison, D. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116491 · Cited by 1,765 · see citing works
Fried, S. K., Bunkin, D. A., & Greenberg, A. S. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.3.4660 · Cited by 1,754 · see citing works
Inoguchi, T., Li, P., Umeda, F., Yu, H. Y., Kakimoto, M., Imamura, M., Aoki, T., Etoh, T., Hashimoto, T., Naruse, M., et al. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1939 · Cited by 1,577 · see citing works
Cell transformation by the superoxide-generating oxidase Mox1
Suh, Y.-A., Arnold, R. S., Lassegue, B., Shi, J., Xu, X., Sorescu, D., Chung, A. B., Griendling, K. K., & Lambeth, J. D. (1999) · Nature · doi:10.1038/43459 · Cited by 1,480 · see citing works
Keaney, J. F., Larson, M. G., Vasan, R. S., Wilson, P. W. F., Lipinska, I., Corey, D., Massaro, J. M., Sutherland, P., Vita, J. A., & Benjamin, E. J. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000058402.34138.11 · Cited by 1,304 · see citing works
ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism
Berg, A. H., Combs, T. P., & Scherer, P. E. (2002) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00524-0 · Cited by 1,211 · see citing works
Adiponectin and Metabolic Syndrome
Matsuzawa, Y., Funahashi, T., Kihara, S., & Shimomura, I. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000099786.99623.ef · Cited by 1,203 · see citing works
Self-citationMonocyte chemoattractant protein 1 in obesity and insulin resistance
Sartipy, P., & Loskutoff, D. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1133870100 · Cited by 1,199 · see citing works
Adiponectin Reduces Atherosclerosis in Apolipoprotein E-Deficient Mice
Okamoto, Y., Kihara, S., Ouchi, N., Nishida, M., Arita, Y., Kumada, M., Ohashi, K., Sakai, N., Shimomura, I., Kobayashi, H., et al. (2002) · Circulation · doi:10.1161/01.cir.0000042707.50032.19 · Cited by 1,030 · see citing works
Self-citationGlobular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis
Yamauchi, T., Kamon, J., Waki, H., Imai, Y., Shimozawa, N., Hioki, K., Uchida, S., Ito, Y., Takakuwa, K., Matsui, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209033200 · Cited by 911 · see citing works
Enhanced expression of PAI–1 in visceral fat: Possible contributor to vascular disease in obeisty
Shimomura, I., Funahasm, T., Takahashi, M., Maeda, K., Kotani, K., Nakamura, T., Yamashita, S., Miura, M., Fukuda, Y., Takemura, K., et al. (1996) · Nature Medicine · doi:10.1038/nm0796-800 · Cited by 890 · see citing works
Self-citationSuperoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis
Sorescu, D., Weiss, D., Lassègue, B., Clempus, R. E., Szöcs, K., Sorescu, G. P., Valppu, L., Quinn, M. T., Lambeth, J. D., Vega, J. D., et al. (2002) · Circulation · doi:10.1161/01.cir.0000012917.74432.66 · Cited by 847 · see citing works
Role of Adiponectin in Preventing Vascular Stenosis
Matsuda, M., Shimomura, I., Sata, M., Arita, Y., Nishida, M., Maeda, N., Kumada, M., Okamoto, Y., Nagaretani, H., Nishizawa, H., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m206083200 · Cited by 809 · see citing works
Self-citationDoes superoxide underlie the pathogenesis of hypertension?
Nakazono, K., Watanabe, N., Matsuno, K., Sasaki, J., Sato, T., & Inoue, M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10045 · Cited by 746 · see citing works
Iwaki, M., Matsuda, M., Maeda, N., Funahashi, T., Matsuzawa, Y., Makishima, M., & Shimomura, I. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1655 · Cited by 740 · see citing works
Self-citationThe perils of portliness: causes and consequences of visceral adiposity.
Montague, C. T., & O’Rahilly, S. (2000) · Diabetes · doi:10.2337/diabetes.49.6.883 · Cited by 735 · see citing works
Regulation of Fasted Blood Glucose by Resistin
Banerjee, R. R., Rangwala, S. M., Shapiro, J. S., Rich, A. S., Rhoades, B., Qi, Y., Wang, J., Rajala, M. W., Pocai, A., Scherer, P. E., et al. (2004) · Science · doi:10.1126/science.1092341 · Cited by 727 · see citing works
Friedman, J. M. (2000) · Nature · doi:10.1038/35007504 · Cited by 701 · see citing works
Matsuzawa, Y., Funahashi, T., & Nakamura, T. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07793.x · Cited by 601 · see citing works
A Novel Superoxide-producing NAD(P)H Oxidase in Kidney
Shiose, A., Kuroda, J., Tsuruya, K., Hirai, M., Hirakata, H., Naito, S., Hattori, M., Sakaki, Y., & Sumimoto, H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007597200 · Cited by 517 · see citing works
Mahadev, K., Motoshima, H., Wu, X., Ruddy, J. M., Arnold, R. S., Cheng, G., Lambeth, J. D., & Goldstein, B. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.1844-1854.2004 · Cited by 513 · see citing works
Prolonged oxidative stress impairs insulin-induced GLUT4 translocation in 3T3-L1 adipocytes.
Rudich, A., Tirosh, A., Potashnik, R., Hemi, R., Kanety, H., & Bashan, N. (1998) · Diabetes · doi:10.2337/diabetes.47.10.1562 · Cited by 483 · see citing works
Roskams, T., Yang, S. Q., Koteish, A., Durnez, A., DeVos, R., Huang, X., Achten, R., Verslype, C., & Diehl, A. M. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63489-x · Cited by 447 · see citing works
Partial leptin deficiency and human adiposity
Farooqi, I. S., Keogh, J. M., Kamath, S., Jones, S., Gibson, W. T., Trussell, R., Jebb, S. A., Lip, G. Y. H., & O'Rahilly, S. (2001) · Nature · doi:10.1038/35102112 · Cited by 407 · see citing works
Maddux, B. A., See, W., Lawrence, J. C., Goldfine, A. L., Goldfine, I. D., & Evans, J. L. (2001) · Diabetes · doi:10.2337/diabetes.50.2.404 · Cited by 405 · see citing works
Olusi, S. (2002) · International Journal of Obesity · doi:10.1038/sj.ijo.0802066 · Cited by 390 · see citing works
Matsuoka, T., Kajimoto, Y., Watada, H., Kaneto, H., Kishimoto, M., Umayahara, Y., Fujitani, Y., Kamada, T., Kawamori, R., & Yamasaki, Y. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119126 · Cited by 360 · see citing works
NADH/NADPH Oxidase and Enhanced Superoxide Production in the Mineralocorticoid Hypertensive Rat
Beswick, R. A., Dorrance, A. M., Leite, R., & Webb, R. C. (2001) · Hypertension · doi:10.1161/hy1101.093423 · Cited by 346 · see citing works
Tirosh, A., Potashnik, R., Bashan, N., & Rudich, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.15.10595 · Cited by 301 · see citing works
Jacob, S., Ruus, P., Hermann, R., Tritschler, H. J., Maerker, E., Renn, W., Augustin, H. J., Dietze, G. J., & Rett, K. (1999) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00089-1 · Cited by 280 · see citing works
ACRP30, a new hormone controlling fat and glucose metabolism
Tsao, T., Lodish, H. F., & Fruebis, J. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01430-9 · Cited by 277 · see citing works
Simons, J. M., Hart, B. A. ‘., Ching, T. R. A. M. I. V., van Dijk, H., & Labadie, R. P. (1990) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(90)90070-y · Cited by 234 · see citing works
Krieger‐Brauer, H. I., & KATHER, H. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115641 · Cited by 233 · see citing works
The Physiology of Cellular Liporegulation
Unger, R. H. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142622 · Cited by 202 · see citing works
Pancreatic β-Cells Express Phagocyte-Like NAD(P)H Oxidase
Oliveira, H. R., Verlengia, R., Carvalho, C. R. D. O., Britto, L. R., Curi, R., & Carpinelli, Â. R. (2003) · Diabetes · doi:10.2337/diabetes.52.6.1457 · Cited by 186 · see citing works
Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors
Yokode, M., Hammer, R. E., Ishibashi, S., Brown, M. S., & Goldstein, J. L. (1990) · Science · doi:10.1126/science.2244210 · Cited by 175 · see citing works
Meyer, J. W., Holland, J. A., Ziegler, L. M., Chang, M., Beebe, G., & Schmitt, M. E. (1999) · Endothelium · doi:10.3109/10623329909165308 · Cited by 140 · see citing works
Krieger‐Brauer, H. I., & KATHER, H. (1995) · Biochemical Journal · doi:10.1042/bj3070549 · Cited by 140 · see citing works
Cotter, M. A., & Cameron, N. E. (2003) · Life Sciences · doi:10.1016/s0024-3205(03)00508-3 · Cited by 119 · see citing works
Hainault, I., Nebout, G., Turban, S., Ardouin, B., Ferré, P., & Quignard‐Boulangé, A. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2002.282.1.e59 · Cited by 99 · see citing works
Expression of Nox4 in osteoclasts
Yang, S., Zhang, Y., Ries, W. L., & Key, L. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20048 · Cited by 80 · see citing works
Shibuya, A., Wada, K., Nakajima, A., Saeki, M., Katayama, K., Mayumi, T., Kadowaki, T., Niwa, H., & Kamisaki, Y. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03059-4 · Cited by 74 · see citing works
PU.1 Is Essential for p47 Promoter Activity in Myeloid Cells
Li, S.-L., Valente, A. J., Zhao, S.-J., & Clark, R. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17802 · Cited by 71 · see citing works
Possible role of aldehydic lipid peroxidation products as chemoattractants.
Curzio, M., Esterbauer, H., Poli, G., Biasi, F., Cecchini, G., Mauro, C. D., Cappello, N., & Mu, D. (1987) · PubMed · Cited by 55 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Takahashi, K. 2000. Glutathione peroxidase: cou- pled enzyme assay. In Experimental protocols for reactive oxygen and nitrogen species. N. Taniguchi and J.M.C. Gutteridge, editors. Oxford University Press. Oxford, United Kingdom. 79-80.
Cited by
Sorted by citations
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199 · see citing works
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989 · see citing works
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522 · see citing works
Oxidative stress, inflammation, and cancer: How are they linked?
Reuter, S., Gupta, S. C., Chaturvedi, M. M., & Aggarwal, B. B. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.09.006 · Cited by 5,441 · see citing works
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works
Inflammation and insulin resistance
Shoelson, S. E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29069 · Cited by 4,769 · see citing works
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143 · see citing works
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824 · see citing works
Reactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · see citing works
Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529 · see citing works
Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145 · see citing works
Reactive Oxygen Species in Metabolic and Inflammatory Signaling
Forrester, S. J., Kikuchi, D. S., Hernandes, M. S., Xu, Q., & Griendling, K. K. (2018) · Circulation Research · doi:10.1161/circresaha.117.311401 · Cited by 2,081 · see citing works
Obesity, Inflammation, and Insulin Resistance
Shoelson, S. E., Herrero, L., & Naaz, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.059 · Cited by 1,806 · see citing works
Bhatti, J. S., Bhatti, G. K., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.010 · Cited by 1,655 · see citing works
Kim, J.-A., Montagnani, M., Koh, K. K., & Quon, M. J. (2006) · Circulation · doi:10.1161/circulationaha.105.563213 · Cited by 1,652 · see citing works
Metabolic syndrome: definitions and controversies
Kassi, E., Pervanidou, P., Kaltsas, G., & Chrousos, G. (2011) · BMC Medicine · doi:10.1186/1741-7015-9-48 · Cited by 1,565 · see citing works
Chlorogenic acid (CGA): A pharmacological review and call for further research
Naveed, M., Hejazi, V., Abbas, M., Kamboh, A. A., Khan, G. J., Shumzaid, M., Ahmad, F., Babazadeh, D., FangFang, X., Modarresi-Ghazani, F., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.10.064 · Cited by 1,586 · see citing works
Adipogenesis and metabolic health
Ghaben, A. L., & Scherer, P. E. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0093-z · Cited by 1,395 · see citing works
Yamauchi, T., Nio, Y., Maki, T., Kobayashi, M., Takazawa, T., Iwabu, M., Okada-Iwabu, M., Kawamoto, S., Kubota, N., Kubota, T., et al. (2007) · Nature Medicine · doi:10.1038/nm1557 · Cited by 1,396 · see citing works
Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome
Maury, E., & Brichard, S. M. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.07.031 · Cited by 1,026 · see citing works
Insulin resistance: review of the underlying molecular mechanisms
Yaribeygi, H., Farrokhi, F. R., Butler, A. E., & Sahebkar, A. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.27603 · Cited by 929 · see citing works
Oxidative stress in obesity: A critical component in human diseases
Marseglia, L., Manti, S., D’Angelo, G., Nicotera, A., Parisi, E., Di Rosa, G., Gitto, E., & Arrigo, T. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms16010378 · Cited by 933 · see citing works
A crucial role for adipose tissue p53 in the regulation of insulin resistance
Minamino, T., Orimo, M., Shimizu, I., Kunieda, T., Yokoyama, M., Ito, T., Nojima, A., Nabetani, A., Oike, Y., Matsubara, H., et al. (2009) · Nature Medicine · doi:10.1038/nm.2014 · Cited by 891 · see citing works
Insulin resistance: a metabolic pathway to chronic liver disease
Bugianesi, E., McCullough, A. J., & Marchesini, G. (2005) · Hepatology · doi:10.1002/hep.20920 · Cited by 900 · see citing works
Obesity, insulin resistance and free fatty acids
Boden, G. (2011) · Current Opinion in Endocrinology, Diabetes & Obesity · doi:10.1097/med.0b013e3283444b09 · Cited by 848 · see citing works
Reactive oxygen species in health and disease
Alfadda, A. A., & Sallam, R. M. (2012) · Journal of Biomedicine and Biotechnology · doi:10.1155/2012/936486 · Cited by 824 · see citing works
Bonnard, C., Durand, A., Peyrol, S., Chanseaume, E., Chauvin, M.-A., Morio, B., Vidal, H., & Rieusset, J. (2008) · Journal of Clinical Investigation · doi:10.1172/jci32601 · Cited by 819 · see citing works
Cellular Mechanisms for Insulin Resistance in Normal Pregnancy and Gestational Diabetes
Barbour, L. A., McCurdy, C. E., Hernandez, T. L., Kirwan, J. P., Catalano, P. M., & Friedman, J. E. (2007) · Diabetes Care · doi:10.2337/dc07-s202 · Cited by 811 · see citing works
The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.
Crewe, C., An, Y. A., & Scherer, P. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88883 · Cited by 732 · see citing works
Mechanisms of insulin resistance in obesity
Ye, J. (2013) · Frontiers of Medicine · doi:10.1007/s11684-013-0262-6 · Cited by 699 · see citing works
The inflammation highway: metabolism accelerates inflammatory traffic in obesity
Johnson, A. R., Justin Milner, J., & Makowski, L. (2012) · Immunological Reviews · doi:10.1111/j.1600-065x.2012.01151.x · Cited by 603 · see citing works
Insulin resistance and cancer risk: An overview of the pathogenetic mechanisms
Arcidiacono, B., Iiritano, S., Nocera, A., Possidente, K., Nevolo, M. T., Ventura, V., Foti, D., Chiefari, E., & Brunetti, A. (2012) · Experimental Diabetes Research · doi:10.1155/2012/789174 · Cited by 606 · see citing works
Metabolic Syndrome, Aging and Involvement of Oxidative Stress
Bonomini, F., Rodella, L. F., & Rezzani, R. (2015) · Aging and Disease · doi:10.14336/ad.2014.0305 · Cited by 599 · see citing works
Gregor, M. F., & Hotamisligil, G. S. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700007-jlr200 · Cited by 586 · see citing works
Parks, B. W., Nam, E., Org, E., Kostem, E., Norheim, F., Hui, S. T., Pan, C., Civelek, M., Rau, C. D., Bennett, B. J., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2012.12.007 · Cited by 544 · see citing works
Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554 · see citing works
Oxidative Stress and Psychological Disorders
Salim, S. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120230309 · Cited by 557 · see citing works
Buchanan, J., Mazumder, P. K., Hu, P., Chakrabarti, G., Roberts, M. W., Yun, U. J., Cooksey, R. C., Litwin, S. E., & Abel, E. D. (2005) · Endocrinology · doi:10.1210/en.2005-0938 · Cited by 555 · see citing works
Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species
Bashan, N., Kovsan, J., Kachko, I., Ovadia, H., & Rudich, A. (2009) · Physiological Reviews · doi:10.1152/physrev.00014.2008 · Cited by 542 · see citing works
The cell biology of fat expansion
Rutkowski, J. M., Stern, J. H., & Scherer, P. E. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201409063 · Cited by 541 · see citing works
Glucocorticoids, metabolism and metabolic diseases
Vegiopoulos, A., & Herzig, S. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.015 · Cited by 535 · see citing works
Boden, G., Duan, X., Homko, C., Molina, E. J., Song, W., Perez, O., Cheung, P., & Merali, S. (2008) · Diabetes · doi:10.2337/db08-0604 · Cited by 468 · see citing works
Current views on type 2 diabetes
Lin, Y., & Sun, Z. (2010) · Journal of Endocrinology · doi:10.1677/joe-09-0260 · Cited by 457 · see citing works
Nakamura, S., Takamura, T., Matsuzawa-Nagata, N., Takayama, H., Misu, H., Noda, H., Nabemoto, S., Kurita, S., Ota, T., Ando, H., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m901488200 · Cited by 426 · see citing works
Martinez-Outschoorn, U. E., Lisanti, M. P., & Sotgia, F. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2014.01.005 · Cited by 423 · see citing works
PAI-1 and the Metabolic Syndrome: Links, Causes, and Consequences
Alessi, M.-C., & Juhan-Vague, I. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000242905.41404.68 · Cited by 390 · see citing works
Hong, S.-H., & Choi, K. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020494 · Cited by 390 · see citing works
Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation
Kendrick, A. A., Choudhury, M., Rahman, S. M., McCurdy, C. E., Friederich, M., Van Hove, J. L. K., Watson, P. A., Birdsey, N., Bao, J., Gius, D., et al. (2011) · Biochemical Journal · doi:10.1042/bj20100791 · Cited by 382 · see citing works
Obstructive Sleep Apnea and Type 2 Diabetes
Tasali, E., Mokhlesi, B., & Van Cauter, E. (2008) · Chest · doi:10.1378/chest.07-0828 · Cited by 371 · see citing works
Cellular senescence in osteoarthritis pathology
McCulloch, K., Litherland, G. J., & Rai, T. S. (2017) · Aging Cell · doi:10.1111/acel.12562 · Cited by 367 · see citing works
Hotamisligil, G. S. (2005) · Diabetes · doi:10.2337/diabetes.54.suppl_2.s73 · Cited by 352 · see citing works
Cellular senescence: at the nexus between ageing and diabetes
Palmer, A. K., Gustafson, B., Kirkland, J. L., & Smith, U. (2019) · Diabetologia · doi:10.1007/s00125-019-4934-x · Cited by 337 · see citing works
Goossens, G. H., Bizzarri, A., Venteclef, N., Essers, Y., Cleutjens, J. P., Konings, E., Jocken, J. W. E., Čajlaković, M., Ribitsch, V., Clément, K., et al. (2011) · Circulation · doi:10.1161/circulationaha.111.027813 · Cited by 324 · see citing works
Nani, A., Murtaza, B., Sayed Khan, A., Khan, N. A., & Hichami, A. (2021) · Molecules · doi:10.3390/molecules26040985 · Cited by 321 · see citing works
Roles of oxidative stress in polycystic ovary syndrome and cancers
Zuo, T., Zhu, M., & Xu, W. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8589318 · Cited by 319 · see citing works
The secretory function of adipocytes in the physiology of white adipose tissue
Wang, P., Mariman, E., Renes, J., & Keijer, J. (2008) · Journal of Cellular Physiology · doi:10.1002/jcp.21386 · Cited by 318 · see citing works
Buford, T. W., Anton, S. D., Judge, A. R., Marzetti, E., Wohlgemuth, S. E., Carter, C. S., Leeuwenburgh, C., Pahor, M., & Manini, T. M. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.04.004 · Cited by 295 · see citing works
De Luca, M., Angrisani, L., Himpens, J., Busetto, L., Scopinaro, N., Weiner, R., Sartori, A., Stier, C., Lakdawala, M., Bhasker, A. G., et al. (2016) · Obesity Surgery · doi:10.1007/s11695-016-2271-4 · Cited by 296 · see citing works
Oxidative stress and metabolic pathologies: from an adipocentric point of view
Le Lay, S., Simard, G., Martinez, M. C., & Andriantsitohaina, R. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/908539 · Cited by 291 · see citing works
Bandyopadhyay, G. K., Yu, J. G., Ofrecio, J., & Olefsky, J. M. (2006) · Diabetes · doi:10.2337/db06-0062 · Cited by 291 · see citing works
Mechanism of increased risk of insulin resistance in aging skeletal muscle
Shou, J., Chen, P.-J., & Xiao, W.-H. (2020) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-020-0523-x · Cited by 283 · see citing works
Essential role of mitochondrial function in adiponectin synthesis in adipocytes
Koh, E. H., Park, J.-Y., Park, H.-S., Jeon, M. J., Ryu, J. W., Kim, M., Kim, S. Y., Kim, M.-S., Kim, S.-W., Park, I. S., et al. (2007) · Diabetes · doi:10.2337/db07-0510 · Cited by 275 · see citing works
Reactive oxygen species and insulin resistance: the good, the bad and the ugly
Tiganis, T. (2011) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.11.006 · Cited by 256 · see citing works
Sarcopenic obesity: time to meet the challenge
Barazzoni, R., Bischoff, S. C., Boirie, Y., Busetto, L., Cederholm, T., Dicker, D., Toplak, H., Van Gossum, A., Yumuk, V., & Vettor, R. (2018) · Clinical Nutrition · doi:10.1016/j.clnu.2018.04.018 · Cited by 260 · see citing works
Adiponectin, Cardiovascular Function, and Hypertension
Wang, Z. V., & Scherer, P. E. (2008) · Hypertension · doi:10.1161/hypertensionaha.107.099424 · Cited by 247 · see citing works
Mitochondrial fatty acid oxidation in obesity
Serra, D., Mera, P., Malandrino, M. I., Mir, J. F., & Herrero, L. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4875 · Cited by 246 · see citing works
Sarcopenic obesity: time to meet the challenge
Barazzoni, R., Bischoff, S., Boirie, Y., Busetto, L., Cederholm, T., Dicker, D., Toplak, H., Van Gossum, A., Yumuk, V., & Vettor, R. (2018) · Obesity Facts · doi:10.1159/000490361 · Cited by 244 · see citing works
Chen, B., Lam, K. S. L., Wang, Y., Wu, D., Lam, M. C., Shen, J., Wong, L., Hoo, R. L. C., Zhang, J., & Xu, A. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.004 · Cited by 238 · see citing works
Lopresti, A. L., & Drummond, P. D. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.05.005 · Cited by 231 · see citing works
Fructose as a key player in the development of fatty liver disease
Basaranoglu, M. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i8.1166 · Cited by 235 · see citing works
Wellen, K. E., Fucho, R., Gregor, M. F., Furuhashi, M., Morgan, C., Lindstad, T., Vaillancourt, E., Gorgun, C. Z., Saatcioglu, F., & Hotamisligil, G. S. (2007) · Cell · doi:10.1016/j.cell.2007.02.049 · Cited by 222 · see citing works
Boden, G., Homko, C., Barrero, C. A., Stein, T. P., Chen, X., Cheung, P., Fecchio, C., Koller, S., & Merali, S. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac4765 · Cited by 214 · see citing works
Plasminogen activator inhibitor-1, adipose tissue and insulin resistance
Alessi, M.-C., Poggi, M., & Juhan-Vague, I. (2007) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32814e6d29 · Cited by 212 · see citing works
Nox enzymes as novel targets for drug development
Lambeth, J. D., Krause, K.-H., & Clark, R. A. (2008) · Seminars in Immunopathology · doi:10.1007/s00281-008-0123-6 · Cited by 212 · see citing works
Stubbins, R. E., Najjar, K., Holcomb, V. B., Hong, J., & Núñez, N. P. (2012) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01488.x · Cited by 204 · see citing works
Chrysohoou, C., Panagiotakos, D. B., Pitsavos, C., Skoumas, I., Papademetriou, L., Economou, M., & Stefanadis, C. (2007) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.05.007 · Cited by 199 · see citing works
Palmieri, V. O., Grattagliano, I., Portincasa, P., & Palasciano, G. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.12.3022 · Cited by 197 · see citing works
Antioxidative enzymes and increased oxidative stress in depressive women
Kodydková, J., Vávrová, L., Zeman, M., Jirák, R., Macášek, J., Staňková, B., Tvrzická, E., & Žák, A. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.06.006 · Cited by 197 · see citing works
The Role of Dietary Advanced Glycation End Products in Metabolic Dysfunction
Sergi, D., Boulestin, H., Campbell, F. M., & Williams, L. M. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900934 · Cited by 194 · see citing works
Mechanisms of endothelial dysfunction in obesity.
Avogaro, A., & de Kreutzenberg, S. V. (2005) · Clinica Chimica Acta · doi:10.1016/j.cccn.2005.04.020 · Cited by 188 · see citing works
Han, C. Y., Umemoto, T., Omer, M., Den Hartigh, L. J., Chiba, T., LeBoeuf, R., Buller, C. L., Sweet, I. R., Pennathur, S., Abel, E. D., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.304998 · Cited by 187 · see citing works
Li, S.-Y., Yang, X., Ceylan-Isik, A. F., Du, M., Sreejayan, N., & Ren, J. (2006) · Diabetologia · doi:10.1007/s00125-006-0229-0 · Cited by 187 · see citing works
Malnutrition in Obesity: Is It Possible?
Kobylińska, M., Antosik, K., Decyk, A., & Kurowska, K. (2022) · Obesity Facts · doi:10.1159/000519503 · Cited by 186 · see citing works
Sahebkar, A., Mohammadi, A., Atabati, A., Rahiman, S., Tavallaie, S., Iranshahi, M., Akhlaghi, S., Ferns, G. A., & Ghayour‐Mobarhan, M. (2013) · Phytotherapy Research · doi:10.1002/ptr.4952 · Cited by 183 · see citing works
Iron homeostasis in the metabolic syndrome
Datz, C., Felder, T. K., Niederseer, D., & Aigner, E. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12032 · Cited by 181 · see citing works
Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce
Li, Q., Hagberg, C. E., Silva Cascales, H., Lang, S., Hyvönen, M. T., Salehzadeh, F., Chen, P., Alexandersson, I., Terezaki, E., Harms, M. J., et al. (2021) · Nature Medicine · doi:10.1038/s41591-021-01501-8 · Cited by 178 · see citing works
PGC-1α in aging and anti-aging interventions
Anderson, R., & Prolla, T. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.04.005 · Cited by 162 · see citing works
Fruit and Vegetable Consumption and Mortality
Leenders, M., Sluijs, I., Ros, M. M., Boshuizen, H. C., Siersema, P. D., Ferrari, P., Weikert, C., Tjønneland, A., Olsen, A., Boutron-Ruault, M.-C., et al. (2013) · American Journal of Epidemiology · doi:10.1093/aje/kwt006 · Cited by 163 · see citing works
Roles of Reactive Oxygen Species on Insulin Resistance in Adipose Tissue
Han, C. Y. (2016) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2016.40.4.272 · Cited by 159 · see citing works
Hypertension in Obesity and the Impact of Weight Loss
Cohen, J. B. (2017) · Current Cardiology Reports · doi:10.1007/s11886-017-0912-4 · Cited by 147 · see citing works
Holloway, G. P., Thrush, A. B., Heigenhauser, G. J. F., Tandon, N. N., Dyck, D. J., Bonen, A., & Spriet, L. L. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00639.2006 · Cited by 147 · see citing works
Sutherland, L. N., Capozzi, L. C., Turchinsky, N. J., Bell, R. C., & Wright, D. C. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90408.2008 · Cited by 147 · see citing works
Calcium and 1,25‐Dihydroxyvitamin D<sub>3</sub> Regulation of Adipokine Expression
Sun, X., & Zemel, M. B. (2007) · Obesity · doi:10.1038/oby.2007.540 · Cited by 137 · see citing works
Alfaradhi, M. Z., Fernandez-Twinn, D. S., Martin-Gronert, M. S., Musial, B., Fowden, A., & Ozanne, S. E. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00049.2014 · Cited by 136 · see citing works
Orellana-Gavaldà, J. M., Herrero, L., Malandrino, M. I., Pañeda, A., Sol Rodríguez-Peña, M., Petry, H., Asins, G., Van Deventer, S., Hegardt, F. G., & Serra, D. (2011) · Hepatology · doi:10.1002/hep.24140 · Cited by 135 · see citing works
Alnahdi, A., John, A., & Raza, H. (2019) · Nutrients · doi:10.3390/nu11091979 · Cited by 134 · see citing works
Nonalcoholic fatty liver disease: a challenge from mechanisms to therapy.
Tarantino, G., Citro, V., & Capone, D. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm9010015 · Cited by 134 · see citing works
Obesity, estrogens and adipose tissue dysfunction - implications for pulmonary arterial hypertension
Mair, K. M., Gaw, R., & MacLean, M. R. (2020) · Pulmonary Circulation · doi:10.1177/2045894020952023 · Cited by 129 · see citing works
Phagocytic NADPH Oxidase Overactivity Underlies Oxidative Stress in Metabolic Syndrome
Fortuño, A., San José, G., Moreno, M. U., Beloqui, O., Díez, J., & Zalba, G. (2006) · Diabetes · doi:10.2337/diabetes.55.01.06.db05-0751 · Cited by 128 · see citing works
Ohashi, K., Ouchi, N., & Matsuzawa, Y. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2010.216 · Cited by 127 · see citing works
- Authors
- Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I.
- Affiliations
- The University of Osaka (JP)
- University of the Ryukyus (JP)
- Nihon University (JP)
- Japan Science and Technology Agency (JP)
- Corresponding author
- Matsuda, Morihiro
- Venue
- Journal of Clinical Investigation
- Published
- 2004-12-15
- Volume
- 114
- Issue
- 12
- Pages
- 1752-1761
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC535065
- OpenAlex
- W2124821727
- Cited by
- 5,508
- References
- 67
- Citations by year
- 2026: 179 · 2025: 219 · 2024: 218 · 2023: 286 · 2022: 289 · 2021: 355 · 2020: 335 · 2019: 365 · 2018: 331 · 2017: 296 · 2016: 316 · 2015: 277 · 2014: 295 · 2013: 295 · 2012: 305
- FWCI
- 79.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Naito Foundation
- Suzuken Memorial Foundation
- Cell Science Research Foundation
- Novartis Foundation
- Japan Research Foundation for Clinical Pharmacology
- Tokyo Biochemical Research Foundation
- Ministry of Education, Culture, Sports, Science and Technology
- Kato Memorial Bioscience Foundation
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Japan Heart Foundation
- Japan Society for the Promotion of Science
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- obesity, metabolic syndrome, oxidative stress, reactive oxygen species, adipose tissue, NADPH oxidase, adipocytes, adipokines, adiponectin, plasminogen activator inhibitor-1, interleukin-6, MCP-1, NADPH oxidase inhibitors, hepatic steatosis, hyperlipidemia, diabetes mellitus, redox state
- MeSH terms
- Adipose Tissue, Aged, Animals, Antioxidants, Body Weight, Cell Differentiation, Dose-Response Relationship, Drug, Female, Humans, Hydrogen Peroxide, Male, Mice, Inbred C57BL, Mice, Obese, Middle Aged, Models, Biological, Obesity, Oxidation-Reduction, RNA, Messenger, Time Factors, Immunoblotting, Lipid Peroxidation, Cytokines, Reactive Oxygen Species, Thiobarbituric Acid Reactive Substances, Adipocytes, Oxidative Stress, NADPH Oxidases, Reverse Transcriptase Polymerase Chain Reaction, Metabolic Syndrome, 3T3-L1 Cells, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
