Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis

Tian, Li-Xing; Tang, Xin; Zhu, Jun-Yu; Luo, Li; Ma, Xiao-Yuan; Cheng, Shao-Wen; Zhang, Wei; Tang, Wan-Qi; Ma, Wei; Yang, Xue; Lv, Chuan-Zhu; Liang, Hua-Ping

doi:10.1186/s12964-020-0523-3

Cytochrome P450 1A1 enhances inflammatory responses and impedes phagocytosis of bacteria in macrophages during sepsis

The hydroxylase cytochrome P450 1A1 (CYP1A1) is regulated by the inflammation-limiting aryl hydrocarbon receptor (AhR), but CYP1A1 immune functions remain unclear. We observed CYP1A1 overexpression in peritoneal macrophages (PMs) isolated from mice following LPS or heat-killed Escherichia. coli (…