Lactylation modification of HIF-1α enhances its stability by blocking VHL recognition

Li, Chengyu; Fu, Chen; Zhou, Wenhan; Li, Hongmin; Liu, Zhaojun; Wu, Gang; He, Tong; Shen, Ming; Liu, Honglin

doi:10.1186/s12964-025-02366-x

Lactylation modification of HIF-1α enhances its stability by blocking VHL recognition

Hypoxia-inducible factor 1α (HIF-1α) is a master regulator of cellular adaptation to hypoxia. Although prolyl hydroxylation-mediated degradation via the von Hippel–Lindau (VHL) ubiquitination complex is a well-established regulatory mechanism, the role of lactate-induced posttranslational modific…