Recent Advances in Osteonecrosis of the Femoral Head: A Focus on Mesenchymal Stem Cells and Adipocytes

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

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Convergence of Wnt, ß-Catenin, and Cadherin Pathways

Nelson, W. J., & Nusse, R. (2004) · Science · doi:10.1126/science.1094291 · Cited by 2,515 · see citing works

TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation

Chen, G., Deng, C., & Li, Y.-P. (2012) · International Journal of Biological Sciences · doi:10.7150/ijbs.2929 · Cited by 1,756 · see citing works

Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?

Chen, Q., Shou, P., Zheng, C., Jiang, M., Cao, G., Yang, Q., Cao, J., Xie, N., Velletri, T., Zhang, X., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2015.168 · Cited by 1,245 · see citing works

Changes in phenotype and differentiation potential of human mesenchymal stem cells aging in vitro

Yang, Y.-H. K., Ogando, C. R., See, C. W., Chang, T.-Y., & Barabino, G. A. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0876-3 · Cited by 637 · see citing works

Adipose-derived and bone marrow mesenchymal stem cells: A donor-matched comparison

Mohamed-Ahmed, S., Fristad, I., Lie, S. A., Suliman, S., Mustafa, K., Vindenes, H., & Idris, S. B. (2018) · Stem Cell Research & Therapy · doi:10.1186/s13287-018-0914-1 · Cited by 515 · see citing works

Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis

Zhu, S., Chen, W., Masson, A., & Li, Y. (2024) · Cell Discovery · doi:10.1038/s41421-024-00689-6 · Cited by 513 · see citing works

Bone marrow adipose tissue is an endocrine organ that contributes to increased circulating adiponectin during caloric restriction

Cawthorn, W., Scheller, E., Learman, B. S., Parlee, S., Simon, B., Mori, H., Ning, X.-M., Bree, A. J., Schell, B. A., Broome, D. T., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.003 · Cited by 506 · see citing works

Convergence between bone and energy homeostases: Leptin regulation of bone mass

Karsenty, G. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.10.008 · Cited by 415 · see citing works

Osteonecrosis of the Femoral Head: an Updated Review of ARCO on Pathogenesis, Staging and Treatment

Hines, J. T., Jo, W.-L., Cui, Q., Mont, M. A., Koo, K., Cheng, E. Y., Goodman, S. B., Ha, Y., Hernigou, P., Jones, L. C., et al. (2021) · Journal of Korean Medical Science · doi:10.3346/jkms.2021.36.e177 · Cited by 250 · see citing works

Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss

Yu, W. H., Zhong, L., Yao, L., Wei, Y., Gui, T., Li, Z., Kim, H., Holdreith, N., Jiang, X., Tong, W., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci140214 · Cited by 214 · see citing works

Alcohol-Induced Adipogenesis in Bone and Marrow: A Possible Mechanism for Osteonecrosis

Wang, Y., Li, Y., Mao, K., Li, J., Cui, Q., & Wang, G. (2003) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000063602.67412.83 · Cited by 199 · see citing works

Polydatin promotes the osteogenic differentiation of human bone mesenchymal stem cells by activating the BMP2-Wnt/β-catenin signaling pathway

Chen, X., Shen, Y.-S., He, M., Yang, F., Yang, P., Pang, F., He, W., Cao, Y., & Wei, Q. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.108746 · Cited by 192 · see citing works

Bone marrow adipose tissue is a unique adipose subtype with distinct roles in glucose homeostasis

Suchacki, K., Tavares, A., Mattiucci, D., Scheller, E., Papanastasiou, G., Gray, C. D., Sinton, M. C., Ramage, L., McDougald, W. A., Lovdel, A., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16878-2 · Cited by 183 · see citing works

Bone marrow fat cell enlargement and a rise in intraosseous pressure in steroid-treated rabbits with osteonecrosis

Miyanishi, K., Yamamoto, T., Irisa, T., Yamashita, A., Jingushi, S., Noguchi, Y., & Iwamoto, Y. (2002) · Bone · doi:10.1016/s8756-3282(01)00663-9 · Cited by 175 · see citing works

The shift in the balance between osteoblastogenesis and adipogenesis of mesenchymal stem cells mediated by glucocorticoid receptor

Han, L., Wang, B., Wang, R., Gong, S., Chen, G., & Xu, W. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1498-0 · Cited by 172 · see citing works

Mesenchymal stem cells overexpressing interleukin-10 attenuate collagen-induced arthritis in mice

Choi, J.-J., Yoo, S.-A., Park, S.-J., Kang, Y.-J., Kim, W.-U., Oh, I.-H., & Cs, C. (2008) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2008.03683.x · Cited by 170 · see citing works

PPAR-γ and Wnt Regulate the Differentiation of MSCs into Adipocytes and Osteoblasts Respectively

Li, Y., Jin, D., Xie, W., Wen, L., Chen, W., Xu, J., Ding, J., & Ren, D. (2017) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x12666171012141908 · Cited by 152 · see citing works

Functionalization of Silk Fibroin Electrospun Scaffolds via BMSC Affinity Peptide Grafting through Oxidative Self-Polymerization of Dopamine for Bone Regeneration

Wu, J., Cao, L., Liu, Y., Zheng, A., Jiao, D., Zeng, D., Wang, X. L., Kaplan, D. L., & Jiang, X. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b22123 · Cited by 142 · see citing works

Decreased Osteogenic Differentiation of Mesenchymal Stem Cells in Alcohol-induced Osteonecrosis

Suh, K. T., Kim, S. W., Roh, H. L., Youn, M. S., & Jung, J. S. (2005) · Clinical Orthopaedics and Related Research · doi:10.1097/01.blo.0000150568.16133.3c · Cited by 136 · see citing works

Circular RNA CDR1as promotes adipogenic and suppresses osteogenic differentiation of BMSCs in steroid-induced osteonecrosis of the femoral head

Chen, G., Wang, Q., Li, Z., Yang, Q., Liu, Y., Du, Z., Zhang, G., & Song, Y. (2020) · Bone · doi:10.1016/j.bone.2020.115258 · Cited by 122 · see citing works

NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation

Hu, M., Xing, L., Zhang, L., Liu, F., Wang, S., Xie, Y., Wang, J., Jiang, H., Guo, J. R., Li, X., et al. (2022) · Aging Cell · doi:10.1111/acel.13551 · Cited by 119 · see citing works

Therapeutic application of mesenchymal stem cells in bone and joint diseases

Liu, Y., Wu, J., Zhu, Y., & Han, J. (2012) · Clinical and Experimental Medicine · doi:10.1007/s10238-012-0218-1 · Cited by 100 · see citing works

Osteogenic effect of bone marrow mesenchymal stem cell-derived exosomes on steroid-induced osteonecrosis of the femoral head

Fang, S., Li, Y., & Chen, P. (2018) · Drug Design Development and Therapy · doi:10.2147/dddt.s178698 · Cited by 100 · see citing works

The Unique Metabolic Characteristics of Bone Marrow Adipose Tissue

Li, Y.-J., Meng, Y., & Yu, X.-J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00069 · Cited by 92 · see citing works

Preventive Effects of Puerarin on Alcohol-induced Osteonecrosis

Wang, Y., Li, Y., Li, Y., Liu, P., & Cui, Q. (2008) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-008-0178-7 · Cited by 82 · see citing works

Adipose-Derived Mesenchymal Stromal Cells in Basic Research and Clinical Applications

Czerwiec, K., Zawrzykraj, M., Deptuła, M., Skoniecka, A., Tymińska, A., Zieliński, J., Kosiński, A., & Pikuła, M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043888 · Cited by 80 · see citing works

Exosomes from miRNA-378-modified adipose-derived stem cells prevent glucocorticoid-induced osteonecrosis of the femoral head by enhancing angiogenesis and osteogenesis via targeting miR-378 negatively regulated suppressor of fused (Sufu)

Nan, K., Zhang, Y., Zhang, X., Li, D., Zhao, Y., Jing, Z., Liu, K., Shang, D., Geng, Z., & Fan, L. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02390-x · Cited by 74 · see citing works

Vangl2 limits chaperone-mediated autophagy to balance osteogenic differentiation in mesenchymal stem cells

Gong, Y., Li, Z., Zou, S., Deng, D., Lai, P., Hu, H., Yao, Y., Hu, L., Zhang, S., Li, K., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.06.011 · Cited by 72 · see citing works

Increased microRNA-93-5p inhibits osteogenic differentiation by targeting bone morphogenetic protein-2

Zhang, Y., Wei, Q., Ding, W., Zhang, L., Wang, H.-C., Zhu, Y., He, W., Chai, Y.-N., & Liu, Y. (2017) · PLoS ONE · doi:10.1371/journal.pone.0182678 · Cited by 71 · see citing works

Cotransplantation of mesenchymal stem cells and endothelial progenitor cells for treating steroid-induced osteonecrosis of the femoral head

Xu, H., Wang, C., Liu, C., Peng, Z., Li, J., Jin, Y., Wang, Y., Guo, J., & Zhu, L. (2021) · Stem Cells Translational Medicine · doi:10.1002/sctm.20-0346 · Cited by 71 · see citing works

Interleukin-17A increases leptin production in human bone marrow mesenchymal stem cells

Noh, M. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.12.010 · Cited by 68 · see citing works

LncRNA expression profiling of BMSCs in osteonecrosis of the femoral head associated with increased adipogenic and decreased osteogenic differentiation

Wang, Q., Yang, Q., Chen, G., Du, Z., Ren, M., Wang, A., Zhao, H., Li, Z., Zhang, G., & Song, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-27501-2 · Cited by 68 · see citing works

Long non‐coding RNA TCONS_00041960 enhances osteogenesis and inhibits adipogenesis of rat bone marrow mesenchymal stem cell by targeting miR‐204‐5p and miR‐125a‐3p

Shang, G., Wang, Y., Xu, Y., Zhang, S., Sun, X., Guan, H., Zhao, X., Wang, Y., Li, Y., & Zhao, G. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26424 · Cited by 67 · see citing works

Pravastatin prevents steroid-induced osteonecrosis in rats by suppressing PPARγ expression and activating Wnt signaling pathway

Jiang, Y., Zhang, Y., Zhang, H., Zhu, B., Li, P., Lu, C., Xu, Y., Chen, W., & Lin, N. (2014) · Experimental Biology and Medicine · doi:10.1177/1535370213519215 · Cited by 63 · see citing works

Osteoclasts and osteoarthritis: Novel intervention targets and therapeutic potentials during aging

Wang, H., Yuan, T., Wang, Y., Liu, C., Li, D., Li, Z., & Sun, S. (2024) · Aging Cell · doi:10.1111/acel.14092 · Cited by 60 · see citing works

Anti-inflammatory role and immunomodulation of mesenchymal stem cells in systemic joint diseases: potential for treatment

MacFarlane, R. J., Graham, S. M., Davies, P., Korres, N., Tsouchnica, H., Heliotis, M., Mantalaris, A., & Tsiridis, E. E. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.746954 · Cited by 58 · see citing works

Exosomal miR-100-5p inhibits osteogenesis of hBMSCs and angiogenesis of HUVECs by suppressing the BMPR2/Smad1/5/9 signalling pathway

Wu, Y., Zhu, W., Yang, Y., Guo, M., Qian, H., Jiang, W., Chen, Y., Lian, C., Xu, Z., Bai, H., et al. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02438-y · Cited by 57 · see citing works

Osteogenesis and angiogenesis are simultaneously enhanced in BMP2-/VEGF-transfected adipose stem cells through activation of the YAP/TAZ signaling pathway

Lee, E., Ko, J., Kim, J., Park, J., Lee, S., & Im, G. (2019) · Biomaterials Science · doi:10.1039/c9bm01037h · Cited by 50 · see citing works

Role of the microenvironment in myeloid malignancies

Goulard, M. C., Dosquet, C., & Bonnet, D. A. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2725-4 · Cited by 46 · see citing works

Osthole stimulates bone formation, drives vascularization and retards adipogenesis to alleviate alcohol‐induced osteonecrosis of the femoral head

Yu, H., Zhu, D., Liu, P., Yang, Q., Gao, J., Huang, Y., Chen, Y., Gao, Y., & Zhang, C. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15103 · Cited by 44 · see citing works

C/EBPα regulates the fate of bone marrow mesenchymal stem cells and steroid-induced avascular necrosis of the femoral head by targeting the PPARγ signalling pathway

Duan, P., Wang, H., Yi, X., Zhang, H., Chen, H., & Pan, Z. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03027-3 · Cited by 40 · see citing works

The role of lncRNA RP11‐154D6 in steroid‐induced osteonecrosis of the femoral head through BMSC regulation

Xiang, S., Zeng, L., & Weng, X. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29161 · Cited by 39 · see citing works

Platelet-rich plasma promotes bone formation, restrains adipogenesis and accelerates vascularization to relieve steroids-induced osteonecrosis of the femoral head

Xu, H., Li, S.-M., Fang, L., Xia, C., Zhang, P., Xu, R., Shi, Z.-Y., Zou, Z., Ge, Q., Wang, P., et al. (2020) · Platelets · doi:10.1080/09537104.2020.1810221 · Cited by 38 · see citing works

Adipocyte-secreted microvesicle-derived miR-148a regulates adipogenic and osteogenic differentiation by targeting Wnt5a/Ror2 pathway

Duan, D., Tang, J. P., Tian, H., Shi, Y., & Jia, J. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119548 · Cited by 37 · see citing works

Induction of Stearoyl-CoA 9-Desaturase 1 Protects Human Mesenchymal Stromal Cells Against Palmitic Acid-Induced Lipotoxicity and Inflammation

Valle, A. D., Vertongen, P., Spruyt, D., Lechanteur, J., Suain, V., Gaspard, N., Brion, J., Gangji, V., & Rasschaert, J. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00726 · Cited by 35 · see citing works

Hypermethylation of Frizzled1 is associated with Wnt/β-catenin signaling inactivation in mesenchymal stem cells of patients with steroid-associated osteonecrosis

Wu, F., Jiao, J., Liu, F., et al. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0220-8 · Cited by 35 · see citing works

Role of mesenchymal stem cells on differentiation in steroid-induced avascular necrosis of the femoral head

Wang, T., Teng, S., Zhang, Y., Wang, F., Ding, H.-J., & Li, G. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3991 · Cited by 34 · see citing works

Changed cellular functions and aberrantly expressed miRNAs and circRNAs in bone marrow stem�cells in osteonecrosis of the femoral head

Xiang, S., Zeng, L., & Weng, X. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4455 · Cited by 34 · see citing works

Glycyrrhizic acid alters the hyperoxidative stress-induced differentiation commitment of MSCs by activating the Wnt/β-catenin pathway to prevent SONFH

Xu, H., Fang, L., Zeng, Q., Chen, J., Ling, H., Xia, H., Ge, Q., Wu, C., Zou, K., Wang, X., et al. (2022) · Food & Function · doi:10.1039/d2fo02337g · Cited by 32 · see citing works

Correlation between baseline femoral neck marrow status and the development of femoral head osteonecrosis in corticosteroid-treated patients: A longitudinal study by MR imaging

Berg, B. C. V., Gilon, R., Malghem, J. J., Lecouvet, F. E., Depresseux, G., & Houssiau, F. A. (2006) · European Journal of Radiology · doi:10.1016/j.ejrad.2006.01.009 · Cited by 31 · see citing works

METTL14 benefits the mesenchymal stem cells in patients with steroid-associated osteonecrosis of the femoral head by regulating the m6A level of PTPN6

Cheng, C., Zhang, H., Zheng, J., Jin, Y., Wang, D., & Dai, Z. (2021) · Aging · doi:10.18632/aging.203778 · Cited by 31 · see citing works

Identification of aberrantly expressed of serum microRNAs in patients with hormone-induced non-traumatic osteonecrosis of the femoral head

Wei, B., & Wei, W. (2015) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.07.016 · Cited by 30 · see citing works

Simvastatin suppresses dexamethasone-induced secretion of plasminogen activator inhibitor-1 in human bone marrow adipocytes

Sakamoto, K., Osaki, M., Hozumi, A., Goto, H., Fukushima, T., Baba, H., & Shindo, H. (2011) · BMC Musculoskeletal Disorders · doi:10.1186/1471-2474-12-82 · Cited by 30 · see citing works

Targeting the IL-1β/IL-1Ra pathways for the aggregation of human islet amyloid polypeptide in an ex vivo organ culture system of the intervertebral disc

Wu, X., Liao, Z., Wang, K., Hua, W., Liu, X., Song, Y., Zhang, Y., Yang, S., & Cao, Y. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0310-7 · Cited by 30 · see citing works

Effects of Extracellular Vesicles from Osteogenic Differentiated Human BMSCs on Osteogenic and Adipogenic Differentiation Capacity of Naïve Human BMSCs

Wang, C., Stöckl, S., Li, S., Herrmann, M., Lukas, C., Reinders, Y., Sickmann, A., & Grässel, S. (2022) · Cells · doi:10.3390/cells11162491 · Cited by 30 · see citing works

Lithium Promotes Osteogenesis via Rab11a-Facilitated Exosomal Wnt10a Secretion and β-Catenin Signaling Activation

Chen, C., Wang, B., Zhao, X., Luo, Y., Fu, L., Qi, X., Ying, Z., Chen, L., Wang, Q., Sun, S., et al. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c04199 · Cited by 30 · see citing works

The effect of combined regulation of the expression of peroxisome proliferator-activated receptor-γ and calcitonin gene-related peptide on alcohol-induced adipogenic differentiation of bone marrow mesenchymal stem cells

Li, J., Wang, Y., Li, Y., Sun, J., & Zhao, G. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2016-4 · Cited by 29 · see citing works

Phytoestrogenic molecule desmethylicaritin suppressed adipogenesis via Wnt/β-catenin signaling pathway

Wang, X.-L., Wang, N., Zheng, L.-Z., Xie, X.-H., Dong, Y., Liu, M.-Y., Yao, Z.-H., Dai, Y., Zhang, G., Yao, X., et al. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.06.008 · Cited by 29 · see citing works

Low Plasma Adiponectin as a Potential Biomarker for Osteonecrosis of the Femoral Head

Shuai, B., Shen, L., Yang, Y., Xie, J., 寿折星, & WEI, B. (2010) · The Journal of Rheumatology · doi:10.3899/jrheum.100342 · Cited by 28 · see citing works

Valproic acid prevents glucocorticoid‑induced osteonecrosis of the femoral head of rats

Zhou, D., Chen, Y., Yin, J., Tao, S., Guo, S., Wei, Z., Feng, Y., & Zhang, C. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3534 · Cited by 28 · see citing works

Dexamethasone-induced plasminogen activator inhibitor-1 expression in human primary bone marrow adipocytes

Hozumi, A., Osaki, M., Sakamoto, K., Goto, H., Fukushima, T., Baba, H., & Shindo, H. (2010) · Biomedical Research · doi:10.2220/biomedres.31.281 · Cited by 27 · see citing works

Influences of hucMSC-exosomes on VEGF and BMP-2 expression in SNFH rats.

Li, R., Chen, C., Rq, Z., Li, Z., Hao, G.-L., & Gc, Z. (2019) · PubMed · doi:10.26355/eurrev_201904_17573 · Cited by 27 · see citing works

Chrysophanic acid shifts the differentiation tendency of BMSCs to prevent alcohol‐induced osteonecrosis of the femoral head

Yu, H., Liu, P., Zhu, D., Yin, J., Yang, Q., Huang, Y., Chen, Y., Zhang, C., & Gao, Y. (2020) · Cell Proliferation · doi:10.1111/cpr.12871 · Cited by 27 · see citing works

Reciprocal effect of microRNA-224 on osteogenesis and adipogenesis in steroid-induced osteonecrosis of the femoral head

Cao, Y., Jiang, C., Wang, X., Wang, H., Yan, Z., & Yuan, H. (2021) · Bone · doi:10.1016/j.bone.2021.115844 · Cited by 27 · see citing works

Glucocorticoid‐induced differentiation of primary cultured bone marrow mesenchymal cells into adipocytes is antagonized by exogenous Runx2

LIN, L., DAI, S., & Fan, G.-Y. (2010) · Apmis · doi:10.1111/j.1600-0463.2010.02634.x · Cited by 26 · see citing works

Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15‐Mediated Redox Signaling

Chen, J., Cui, Z., Wang, Y., Lyu, L., Feng, C., Feng, D., Cheng, Y., Li, Z., & Sun, S. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3182368 · Cited by 26 · see citing works

Knocking down clock control gene CRY1 decreases adipogenesis via canonical Wnt/β-catenin signaling pathway

Sun, S., Zhou, L., Yu, Y., Zhang, T., & Wang, M. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.10.134 · Cited by 25 · see citing works

P‐glycoprotein overexpression in bone marrow–derived multipotent stromal cells decreases the risk of steroid‐induced osteonecrosis in the femoral head

Han, N., Li, Z., Cai, Z., Yan, Z., Hua, Y., & Xu, C. B. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12917 · Cited by 24 · see citing works

Elevated Expression of Dkk-1 by Glucocorticoid Treatment Impairs Bone Regenerative Capacity of Adipose Tissue-Derived Mesenchymal Stem Cells

Kato, T., Khánh, V. C., Sato, K., Kimura, K., Yamashita, T., Sugaya, H., Yoshioka, T., Mishima, H., & Ohneda, O. (2017) · Stem Cells and Development · doi:10.1089/scd.2017.0199 · Cited by 24 · see citing works

Neohesperidin Ameliorates Steroid-Induced Osteonecrosis of the Femoral Head by Inhibiting the Histone Modification of lncRNA HOTAIR

Yuan, S., Zhang, C., Zhu, Y., & Wang, B. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s255276 · Cited by 23 · see citing works

Glucocorticoids promote steroid-induced osteonecrosis of the femoral head by down-regulating serum alpha-2-macroglobulin to induce oxidative stress and facilitate SIRT2-mediated BMP2 deacetylation

Fang, S., He, T., You, M., Zhu, H., & Chen, P. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.12.026 · Cited by 23 · see citing works

Glucocorticoid Enhanced the Expression of Ski in Osteonecrosis of Femoral Head: The Effect on Adipogenesis of Rabbit BMSCs

Zhao, X., Wei, Z., Li, D., Yang, Z., Tian, M., & Kang, P. (2019) · Calcified Tissue International · doi:10.1007/s00223-019-00592-3 · Cited by 21 · see citing works

Preventive effects of siRNA targeting PPARγ gene on steroid-induced osteonecrosis in rabbits

Li, J., Li, Y., Wang, Y., Liu, M., & Zhao, G.-Q. (2014) · Connective Tissue Research · doi:10.3109/03008207.2014.941106 · Cited by 19 · see citing works

Evaluation of Browning Agents on the White Adipogenesis of Bone Marrow Mesenchymal Stromal Cells: A Contribution to Fighting Obesity

Maio, G. D., Alessio, N., Demirsoy, İ. H., Peluso, G., Perrotta, S., Monda, M., & Bernardo, G. D. (2021) · Cells · doi:10.3390/cells10020403 · Cited by 19 · see citing works

Injectable heat-sensitive nanocomposite hydrogel for regulating gene expression in the treatment of alcohol-induced osteonecrosis of the femoral head

Fu, Z., Lai, Y., Zhuang, Y., & Lin, F. (2023) · APL Bioengineering · doi:10.1063/5.0130711 · Cited by 19 · see citing works

Ethyl acetate fraction of Huogu formula inhibits adipogenic differentiation of bone marrow stromal cells via the BMP and Wnt signaling pathways

Kong, X., Li, X., Zhang, C., Zhu, L., Liu, C., Qin, Q., Liu, C., Wang, Q., Zhu, J., Wu, X., et al. (2017) · International Journal of Biological Sciences · doi:10.7150/ijbs.18430 · Cited by 18 · see citing works

Activation of aldehyde dehydrogenase 2 protects ethanol‐induced osteonecrosis of the femoral head in rat model

Lin, X., Zhu, D., Wang, K., Luo, P., Rui, G., Gao, Y., Liu, F., & Yu, H. (2022) · Cell Proliferation · doi:10.1111/cpr.13252 · Cited by 17 · see citing works

CRISPR/Cas9 from bench to bedside: what clinicians need to know before application?

Li, Z., & Li, C. (2020) · Military Medical Research · doi:10.1186/s40779-020-00292-2 · Cited by 16 · see citing works

Adipose tissue in bone regeneration - stem cell source and beyond

Labusca, L. S. (2022) · World Journal of Stem Cells · doi:10.4252/wjsc.v14.i6.372 · Cited by 15 · see citing works

Huogu injection alleviates SONFH by regulating adipogenic differentiation of BMSCs via targeting the miR-34c-5p/MDM4 pathway

Yang, F., Zhang, X., Song, T., Li, X., Lv, H., Li, T., Zhao, J., Liu, Z., Zhang, X., Hou, Y., et al. (2022) · Gene · doi:10.1016/j.gene.2022.146705 · Cited by 15 · see citing works

The potential effect of BMSCs with miR‐27a in improving steroid-induced osteonecrosis of the femoral head

Cui, Y., Huang, T., Zhang, Z., Yang, Z., Hao, F., Yuan, T., & Zhou, Z. (2022) · Scientific Reports · doi:10.1038/s41598-022-25407-8 · Cited by 14 · see citing works

Molecular and Physiological Effects of Browning Agents on White Adipocytes from Bone Marrow Mesenchymal Stromal Cells

Maio, G. D., Alessio, N., Peluso, G., Perrotta, S., Monda, M., & Bernardo, G. D. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012151 · Cited by 13 · see citing works

A specific affinity cyclic peptide enhances the adhesion, expansion and proliferation of rat bone mesenchymal stem cells on β‑tricalcium phosphate scaffolds

Sun, T., Man, Z., Peng, C., Wang, G., & Sun, S. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10335 · Cited by 12 · see citing works

MAGL blockade alleviates steroid-induced femoral head osteonecrosis by reprogramming BMSC fate in rat

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Culture-Expanded Autologous Adipose-Derived Mesenchymal Stem Cell Treatment for Osteonecrosis of the Femoral Head

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β-catenin inhibition disrupts the homeostasis of osteogenic/adipogenic differentiation leading to the development of glucocorticoid-induced osteonecrosis of the femoral head

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Jintiange capsule ameliorates glucocorticoid-induced osteonecrosis of the femoral head in rats by regulating the activity and differentiation of BMSCs

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Serum Amyloid A Correlates With the Osteonecrosis of Femoral Head by Affecting Bone Metabolism

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MiRNA-320a-5p contributes to the homeostasis of osteogenesis and adipogenesis in bone marrow mesenchymal stem cell

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The therapeutic effect of adipose-derived lipoaspirate cells in femoral head necrosis by improving angiogenesis

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Dimethyloxaloylglycine increases bone repair capacity of adipose-derived stem cells in the treatment of osteonecrosis of the femoral head

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Steroid changes adipokine concentration in the blood and bone marrow fluid

FUKUSHIMA, T., Hozumi, A., Tomita, M., Yonekura, A., Miyata, N., MIYAMOTO, T., Taguchi, K., Goto, H., Tsuda, K., & Osaki, M. (2016) · Biomedical Research · doi:10.2220/biomedres.37.215 · Cited by 6 · see citing works

Microfibrillar-associated protein 5 suppresses adipogenesis by inhibiting essential coactivator of PPARγ

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β-catenin inhibition disrupts the homeostasis of osteogenic/adipogenic differentiation leading to the development of glucocorticoid-induced osteonecrosis of the femoral head

Xia, C., Xu, H., Fang, L., Chen, J., Yuan, W., Fu, D., Wang, X., He, B., Xiao, L., Wu, C., et al. (2023) · eLife · doi:10.7554/elife.92469 · Cited by 6 · see citing works

Therapeutic effect of low-dose BMSCs-Loaded 3D microscaffold on early osteonecrosis of the femoral head

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Exercise-Induced Muscle–Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging

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Sclerostin-silenced human umbilical cord mesenchymal stem cells ameliorate bone metabolism in steroid-induced femoral head necrosis

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Diagnostic lncRNA biomarkers and immune-related ceRNA networks for osteonecrosis of the femoral head in metabolic syndrome identified by plasma RNA sequencing and machine learning

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Nuciferine ameliorates steroid-induced osteonecrosis of the femoral head by inhibiting BMSCs ferroptosis via HIF-1α

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DMOG pretreatment restores osteogenic–adipogenic balance and mitochondrial function in ONFH BMSCs through the HIF-1α/Homer3 pathway

Chen, Q., Yi, L., Nie, P., Wang, J., Zhu, J., Peng, J., & Weng, T. (2026) · Stem Cell Research & Therapy · doi:10.1186/s13287-026-05026-0 · Cited by 3 · see citing works

A bioactive magnesium alloy scaffold integrated with BMSCs-Loaded 3D microspheres synergistically promotes femoral head osteonecrosis repair by improving the osteogenic-angiogenic microenvironment

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Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Lv, Z., Cai, X., Xu, Y., Yang, X. L., Wang, R., Wang, H., Bian, Y., Xu, J., Lü, J., Liu, L., et al. (2026) · Advanced Science · doi:10.1002/advs.75897 · Cited by 1 · see citing works

microRNA-576-5p ameliorates dexamethasone-induced BMSC injury by suppressing ANXA2

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Pravastatin combined with fibrin sealant-embedded BMSCs enhances recovery in steroid-induced avascular necrosis of the femoral head

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miR-199a-3p Promotes Adipogenic Differentiation to Aggravate Steroid-Induced Osteonecrosis of Femoral Head via the ITGB8/FAK–ERK/RUNX2 Pathway

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CT-based radiomics for modeling surgical decision-making in young and middle-aged patients with ARCO stage III osteonecrosis of the femoral head: an age-stratified retrospective study

Zhang, X., Qiu, P., Shi, G., Xia, T., Zhang, N., Xu, T., Li, Y., Wang, Z., Shen, J., & Wu, T. H. (2026) · BMC Musculoskeletal Disorders · doi:10.1186/s12891-026-09670-8

Stem Cells in Aging and Anti-Aging

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Single-cell and multi-layer analysis identifies state-restricted stromal remodeling in steroid-associated osteonecrosis of the femoral headPreprint

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Effect of stellate ganglion block on perioperative psychological symptoms and recovery after total hip arthroplasty for osteonecrosis of the femoral head in non-elderly patients: a randomized controlled trial

Fan, X., Huang, Z., Li, X., Li, J., Lin, B., & Zhang, X. (2026) · BMC Anesthesiology · doi:10.1186/s12871-026-04097-z

mTORC1-regulated LDL receptor increasing and oxidized lipid accumulation in osteocytes participate in trauma-induced osteonecrosis of the femoral head

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PPARγ mediated ferroptosis in metabolic bone diseases

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Vascularized bone organoids: current advances and a biomimetic platform for osteonecrosis of the femoral head

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Mesenchymal Stromal Cell Spheroids as an Emerging Regenerative Strategy for Osteonecrosis of the Femoral Head

Mukhlis, S., Imanbekova, M., Saginova, D., Sarsenova, M., Nurgaliyeva, A., Altaeva, N., & Ogay, V. B. (2026) · Cells · doi:10.3390/cells15191787

Spin-State Engineering of Asymmetric Fe-PN3 Single-Atom Nanozyme Enables Redox Microenvironment Reprogramming in Osteonecrosis.

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Extracellular Vesicles Derived from Akkermansia muciniphila Promote Osteogenesis and Inhibit Adipogenesis of Mesenchymal Stem Cells via Activation of the Wnt/β-catenin Pathway

Lou, H., & Cui, Y. (2026) · Applied Biochemistry and Microbiology · doi:10.1134/s0003683826601423

Osteoclast-derived exosomal miR-378a-3p targets FTO-mediated m6A modification to promote osteogenesis and inhibit osteocyte apoptosis in alcohol-induced osteonecrosis of the femoral head

Zhao, C., Liu, J., Chen, D., Guan, D.-H., Guo, L., Wang, W., Xu, Q., Tao, H., Niu, C., Sun, B., et al. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1975355

Multiscale Stem Cell Technologies for Osteonecrosis of the Femoral Head

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Application of bone marrow mesenchymal stem cells to the treatment of osteonecrosis of the femoral head.

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DMOG pretreatment restores osteogenic–adipogenic balance and mitochondrial function in ONFH BMSCs through the HIF-1α/Homer3 pathway

Chen, Q., Yi, L., Nie, P., Wang, J., Zhu, J., Peng, J., & Weng, T. (2026) · Stem Cell Research & Therapy · doi:10.1186/s13287-026-05026-0 · Cited by 3 · see citing works

Research status and progress of bone marrow mesenchymal stem cells for osteonecrosis of femoral head

Cheng, Y., Wang, M., Xu, P., & Tan, M. (2023) · MEDS Clinical Medicine · doi:10.23977/medsc.2023.040103

Altered lineage commitment of bone marrow mesenchymal stem cells in idiopathic osteonecrosis of the femoral head

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