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Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke
Open accessAbstract
Emerging evidence suggests that gut-brain-microbiota axis (GBMAx) may play a pivotal role linking gastrointestinal and neuronal disease. In this review, we summarize the latest advances in studies of GBMAx in inflammatory bowel disease (IBD) and ischemic stroke. A more thorough understanding of the GBMAx could advance our knowledge about the pathophysiology of IBD and ischemic stroke and help to identify novel therapeutic targets via modulation of the GBMAx.
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“Bacterial metabolites, also known as post-antibiotics (121) or postbiotics, were treated with the bacterial product butyrate, an SCFA, in a study with SOD1G93A mice (50).”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [50]
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“Butyrate treatment improves intestinal integrity and microbial homeostasis, acting along the brain–gut axis, and was found to have beneficial effects in SOD1G93A mice in terms of extending the lifespan and delaying the progression of ALS.”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [50]
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The gastrointestinal-brain-microbiota axis: a promising therapeutic target for ischemic stroke
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BackgroundThe Involvement of Immune Cells Between Ischemic Stroke and Gut Microbiota
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BackgroundBifidobacteria and Psychobiotic Therapy: Current Evidence and Future Prospects
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“Gut microbiota–brain interaction opens a new window for better understanding the pathogenesis of many diseases such as inflammatory bowel disease (IBD) [4], autism [5], and major depressive disorder (MDD) [6].”
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“Previous studies have reported that iNOS-derived NO following chronic stress may induce depressive-like behaviors in mice (Zhou et al., 2007).”
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“and microbiota composition, thus leading to a paradigm shift in modern medicine and science (Zhao et al., 2018).”
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Beyond the Brain: Attention Deficit/Hyperactivity Disorder and the Gut-Brain Axis
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“The bidirectional feedback loop is closed by regulatory signals from the brain via the ENS and the VN to influence gut motility, hormonal secretion, immune function and permeability [8,43].”
InfluentialThe gut-brain connection: Inflammatory bowel disease increases risk of acute ischemic stroke
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Bibliometric analysis of the gut microbiota and stroke from 2002 to 2022
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“In particular, dysregulation of the gut-brain-microbiota axis consisting of bidirectional interactions between the gut and brainmay play a unique role in the pathophysiology connecting IBD to AIS [13].”
BackgroundQuiescent ulcerative colitis and Crohn’s disease have potential effect on cognitive function
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“This implies that the balance of gut microbiota will have significant effects on the brain function (Zhao et al .”
BackgroundMañosa, M., Calafat, M., Francia, E., Riba, F., Mesonero, F., Suárez, C., García‐López, S., Callau, F. L., Calvet, X., Domènech, E., et al. (2025) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2025.502529 · Cited by 2
Influence of diet on the gut microbiota
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Elucidating the Role of Gut-Brain-Axis in Neuropsychiatric and Neurological Disorders
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“This inflammatory cascade may further aggravate barrier injury and contribute to a pathological feedback loop between the brain and gut (Zhao et al., 2014; Zhao et al., 2018).”
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“…когнитивных функций пациента целесообразно применение опрос-ника MMSE (Mini Mental state Examination), шкалы демен-ции Матиса, батареи тестов для оценки лобных дисфунк-ций, FAB (Frontal Assessment Bullory) и шкалы глобального клинического снижения (Global Deterioration Scale – GDS) [4, 15, 19].”
Gut Microbiota Regulation of Cerebral Stroke
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Kaitan Antara Gangguan Perkembangan dan Perilaku Anak dengan Gut-Brain Axis
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The Link between Brain Infarction and the Gut Microbiome —— Brain-Gut Axis
Li, Y., Lin, H., & Yu, T. (2022) · MEDS Clinical Medicine · doi:10.23977/medsc.2022.030508
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Metadata
- Authors
- Zhao, L., Xiong, Q., Stary, C. M., Mahgoub, O. K., Ye, Y., Gu, L., Xiong, X., & Zhu, S.
- Affiliations
- Renmin Hospital of Wuhan University (CN)
- Stanford Medicine (US)
- First Affiliated Hospital Zhejiang University (CN)
- Corresponding author
- Xiong, Xiaoxing
- Zhu, Shengmei
- Venue
- Journal of Neuroinflammation
- Published
- 2018-12
- Volume
- 15
- Issue
- 1
- Pages
- 339-339
- ISSN
- 1742-2094 (ISSN-L)
- PMC
- PMC6290529
- OpenAlex
- W2904712122
- Cited by
- 113
- References
- 97
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 13 · 2023: 23 · 2022: 23 · 2021: 17 · 2020: 14 · 2019: 7
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Neuroinflammation (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81571147, 81870939)
- American Heart Association (14FTF19970029)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut-brain-microbiota axis, inflammatory bowel disease, ischemic stroke, gut microbiota, neuroinflammation, two-way communication, therapeutic target
- MeSH terms
- Gastrointestinal Microbiome, Animals, Brain Ischemia, Humans, Inflammatory Bowel Diseases
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