The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke
Open accessAbstract
Emerging evidence suggests that gut-brain-microbiota axis (GBMAx) may play a pivotal role linking gastrointestinal and neuronal disease. In this review, we summarize the latest advances in studies of GBMAx in inflammatory bowel disease (IBD) and ischemic stroke. A more thorough understanding of the GBMAx could advance our knowledge about the pathophysiology of IBD and ischemic stroke and help to identify novel therapeutic targets via modulation of the GBMAx.
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“Bacterial metabolites, also known as post-antibiotics (121) or postbiotics, were treated with the bacterial product butyrate, an SCFA, in a study with SOD1G93A mice (50).”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [50]
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“Butyrate treatment improves intestinal integrity and microbial homeostasis, acting along the brain–gut axis, and was found to have beneficial effects in SOD1G93A mice in terms of extending the lifespan and delaying the progression of ALS.”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [50]
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Citations
Cites
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Items 101–113 of 113
Upregulation of CXCL1 and FCGR1A is Associated With the ischemic stroke and Crohn’s DiseasePreprint
Zhang, W., Li, Y., Xu, H., Li, C., Zhang, Y., & Han, B. (2023) · Research Square · doi:10.21203/rs.3.rs-2676536/v1
Boamah, V. E., Ekuadzi, E., & Mante, P. K. (2023) · Research Square · doi:10.21203/rs.3.rs-2775005/v1
Microbiome and multiple sclerosis
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(2023) · International Journal of Biology Pharmacy and Allied Sciences · doi:10.31032/ijbpas/2023/12.10.1031
Probiotic: Global Market, Mechanisms of Action, and Beneficial Effects on Health
Cissé, H., Oumar, D. A., Ouédraogo, G. A., Sawadogo, A., Zongo, C., Tidjani, A., & Savadogo, A. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1007311
Crosstalk between gut-brain axis and brain components along with associated neurological disorders
Bindal, P., Kaushal, S., Singh, C., & Singh, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-21680-0.00005-5
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GETECCU position paper on fragility, advanced age and inflammatory bowel disease
Mañosa, M., Calafat, M., Francia, E., Riba, F., Mesonero, F., Suárez, C., García-López, S., Callau, F. L., Calvet, X., Domènech, E., et al. (2025) · Gastroenterología y Hepatología (English Edition) · doi:10.1016/j.gastre.2025.502529
Stroke in paediatric Crohn’s disease
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“In fact, studies have shown a bidirectional relationship between the gut and the brain via multiple communication pathways [30–32].”
Li, Z., Fu, J., Pu, J., Qian, Y., Gai, X., & Li, L. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1773086
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Kuang, X., & Zheng, X. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27167291
“Within the brainstem, these signals are primarily integrated into the nucleus tractus solitarius (NTS) and the dorsal motor nucleus of the vagus (DMV) [56].”
Metadata
- Authors
- Zhao, L., Xiong, Q., Stary, C. M., Mahgoub, O. K., Ye, Y., Gu, L., Xiong, X., & Zhu, S.
- Affiliations
- Renmin Hospital of Wuhan University (CN)
- Stanford Medicine (US)
- First Affiliated Hospital Zhejiang University (CN)
- Corresponding author
- Xiong, Xiaoxing
- Zhu, Shengmei
- Venue
- Journal of Neuroinflammation
- Published
- 2018-12
- Volume
- 15
- Issue
- 1
- Pages
- 339-339
- ISSN
- 1742-2094 (ISSN-L)
- PMC
- PMC6290529
- OpenAlex
- W2904712122
- Cited by
- 113
- References
- 97
- Citations by year
- 2026: 5 · 2025: 11 · 2024: 13 · 2023: 23 · 2022: 23 · 2021: 17 · 2020: 14 · 2019: 7
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Neuroinflammation (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81571147, 81870939)
- American Heart Association (14FTF19970029)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- gut-brain-microbiota axis, inflammatory bowel disease, ischemic stroke, gut microbiota, neuroinflammation, two-way communication, therapeutic target
- MeSH terms
- Gastrointestinal Microbiome, Animals, Brain Ischemia, Humans, Inflammatory Bowel Diseases
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