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Trends in ectopic pregnancy, hydatidiform mole and miscarriage in the largest obstetrics and gynaecology hospital in China from 2003 to 2013
Open accessAbstract
BACKGROUND: Ectopic pregnancies, miscarriages and hydatidiform moles are the major types of pathological pregnancies in the early gestations of pregnancy and constitute an important public health problem. The trends and incidences of these pathological pregnancies may vary by ethnicity and geographical regions. This has not been fully investigated in the Chinese population. In this study we retrospectively report the trends of pathological pregnancies in Chinese population. METHODS: Data on 22,511 women with ectopic pregnancy, hydatidiform mole and miscarriage were collected from the largest obstetrics and gynaecology hospital in China from 2003 to 2013. Data included age at diagnosis and the annual number of women with diagnosed ectopic pregnancy, hydatidiform mole and miscarriage. RESULTS: The total number of ectopic pregnancy, hydatidiform mole and miscarriage was increased 3.5folds in 2013 compared to 2003. Ectopic pregnancy is the leading pathological pregnancy and miscarriage is increasing at a greater rate among the pathological pregnancies. The median age of women with hydatidiform mole at diagnosis significantly increased from 25.5 years to 29 years (p = 0.002), however the median age for other pathological pregnancies was not different between 2003 and 2013. The number of women with hydatidiform mole at diagnosis who were over 40 years old has increased. The mean maternal age is increased from 28.1 years old in 2003 to 29.4 years old in 2013 in this hospital. CONCLUSION: We speculate that the increased maternal age may contribute to the increase in these pathological pregnancies between 2003 and 2013 in China.
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The literature search identified nine large cohort studies that reported on miscarriage risk in an aggregated total of 4,638,974 pregnancies.
“Our literature search identified nine large cohort studies that reported on miscarriage risk in an aggregated total of 4,638,974 pregnancies (Table 2). 24-31”
From Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss (2021) · cites this paper as [24]
The Methods and Results describe a retrospective hospital study that recorded 6,897 miscarriages among 22,511 women with pathological pregnancies. It can be identified as a study reporting miscarriage cases, but it does not follow a cohort of pregnancies to estimate miscarriage risk. The cited paper also cannot establish the citing authors’ literature-search count or aggregate of 4,638,974 pregnancies. (LLM, conf=0.85)
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Metadata
- Authors
- Li, X.-L., Du, D.-F., Chen, S.-J., Zheng, S.-H., Lee, A. C., & Chen, Q.
- Affiliations
- Shanghai Medical College of Fudan University (CN)
- University of Auckland (NZ)
- Corresponding author
- Chen, Qi
- Venue
- Reproductive Health
- Published
- 2016-05-20
- Volume
- 13
- Issue
- 1
- Pages
- 58-58
- ISSN
- 1742-4755 (ISSN-L)
- PMC
- PMC4875747
- OpenAlex
- W2402102387
- Cited by
- 25
- References
- 25
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 3
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Reproductive Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ResearchSpace (University of Auckland) (submittedVersion, cc-by)
- Funders
- traditional Chinese medicine research fund of Shanghai Municipal Commission of Health and Family Planning (2014JP002A)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Trophoblastic Disease Studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Keywords
- ectopic pregnancy, hydatidiform mole, miscarriage, pathological pregnancy, temporal trends, maternal age, age at diagnosis
- MeSH terms
- Abortion, Spontaneous, Adult, Age Factors, China, Female, Hospitals, Humans, Hydatidiform Mole, Maternal Age, Pregnancy, Pregnancy, Ectopic, Retrospective Studies, Incidence
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