Evaluation of circulating sRAGE in osteoporosis according to BMI, adipokines and fracture risk: a pilot observational study
Open accessAbstract
BACKGROUND: Osteoporosis is a systemic metabolic disease based on age-dependent imbalance between the rates of bone formation and bone resorption. Recent studies on the pathogenesis of this disease identified that bone remodelling impairment, at the base of osteoporotic bone fragility, could be related to protein glycation, in association to oxidative stress. The glycation reactions lead to the generation of glycation end products (AGEs) which, in turn, accumulates into bone, where they binds to the receptor for AGE (RAGE). The aim of this study is to investigate the potential role of circulating sRAGE in osteoporosis, in particular evaluating the correlation of sRAGE with the fracture risk, in association with bone mineral density, the fracture risk marker FGF23, and lipid metabolism. RESULTS: Circulating level of soluble RAGE correlate with osteopenia and osteoporosis level. Serum sRAGE resulted clearly associated on the one hand to bone fragility and, on the other hand, with BMI and leptin. sRAGE is particularly informative because serum sRAGE is able to provide, as a single marker, information about both the aspects of osteoporotic disease, represented by bone fragility and lipid metabolism. CONCLUSIONS: The measure serum level of sRAGE could have a potential diagnostic role in the monitoring of osteoporosis progression, in particular in the evaluation of fracture risk, starting from the prevention and screening stage, to the osteopenic level to osteoporosis.
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Circulating levels of sRAGE have been shown to correlate with osteopenia, osteoporosis, and bone fragility, which has led to the suggestion that increased sRAGE levels in the blood may reflect increased osteoclast activity systemically.
“Although increased levels of sRAGE might be expected to inhibit bone resorption, circulating levels of sRAGE have been shown to correlate with osteopenia, osteoporosis, and bone fragility, which has led to the suggestion that increased sRAGE levels in the blood may reflect increased osteoclast activity systemically (52).”
From Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight (2020) · cites this paper as [52]
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- Authors
- Galliera, E., Marazzi, M. G., Gazzaruso, C., Gallotti, P., Coppola, A., Montalcini, T., Pujia, A., & Corsi Romanelli, M. M.
- Affiliations
- University of Milan (IT)
- Magna Graecia University (IT)
- Corresponding author
- Galliera, Emanuela
- ORCID
- Venue
- Immunity & Ageing
- Published
- 2017-06-14
- Volume
- 14
- Issue
- 1
- Pages
- 13-13
- ISSN
- 1742-4933 (ISSN-L)
- PMC
- PMC5471670
- OpenAlex
- W2625541827
- Cited by
- 18
- References
- 56
- Citations by year
- 2026: 2 · 2024: 2 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 3
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Immunity & Ageing (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Banca del Monte di Lombardia (15-5-3017000568)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- osteoporosis, soluble receptor for advanced glycation end products, fracture risk, bone mineral density, body mass index, leptin, adipokines, fibroblast growth factor 23, lipid metabolism, bone fragility, advanced glycation end products, oxidative stress, osteopenia, biomarkers
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