Cited by 13Malaria Research and ControlVaccine Coverage and HesitancyTravel-related health issues

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

A narrative review of the RTS S AS01 malaria vaccine and its implementation in Africa to reduce the global malaria burden

Open access

Ogieuhi, Ikponmwosa Jude, Ajekiigbe, Victor Oluwatomiwa, Kolo-Manma, Kenneth, Akingbola, Adewunmi, Odeniyi, Temiloluwa Adebayo, Soyemi, Toluwalashe Sogbenga, Ayomide, Jagunmolu Habiblah, Thiyagarajan, Barkavi, Awolola, Busayo Dorcas·2024·Discover Public Health

DOI 10.1186/s12982-024-00284-w

Open this paper in CoChat — free account Open PDF

Abstract

The RTS, S/AS01 vaccine is a significant milestone in advancing malaria control, especially in Africa, where the heavy burden of this disease is prevalent. The objective of this study is to discuss the effectiveness and utilization of the RTS, S/AS01 vaccine in Africa while simultaneously addressing the gaps and associated issues. We also explore briefly the R21/Matrix-M vaccines recommended by the World Health Organization (WHO) for children aged five months and older. Essential considerations include but are not limited to the vaccine's effectiveness, implementation challenges, available funding sources, public acceptance, and compatibility with various conventional prevention methods for malaria, like insecticide-coated bed nets and antimalarial medicines. This paper also examines the global practices for integrating vaccines into public health systems and policies while emphasizing sustainable and equitable approaches. By drawing from the lessons learned from the implementations of pilot programs as well as early adoption of the RTS, S/AS01 malaria vaccine, this perspective study tries to identify the key factors that may enhance the impact of the vaccine in the fight against malaria and significantly contribute to the vision of complete eradication the disease. Further research needs to be carried out regarding the efficacy and duration of protection of the RTS, S/AS01 vaccine.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1186/s12982-024-00284-w

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015
Bhatt, S., Weiss, D. J., Cameron, E., Bisanzio, D., Mappin, B., Dalrymple, U., Battle, K. E., Moyes, C. L., Henry, A., Eckhoff, P. A., et al. (2015) · Nature · doi:10.1038/nature15535 · Cited by 3,225
Efficacy and safety of RTS,S/AS01 malaria vaccine with or without a booster dose in infants and children in Africa: final results of a phase 3, individually randomised, controlled trial
† (2015) · The Lancet · doi:10.1016/s0140-6736(15)60721-8 · Cited by 1,627
RTS,S/AS01 vaccine (Mosquirix™): an overview
Laurens, M. B. (2019) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2019.1669415 · Cited by 498
The 2023 WHO World malaria report
Venkatesan, P. (2024) · The Lancet Microbe · doi:10.1016/s2666-5247(24)00016-8 · Cited by 477
Efficacy of RTS,S/AS01E Vaccine against Malaria in Children 5 to 17 Months of Age
Bejon, P., Lusingu, J., Olotu, A., Leach, A. J., Lievens, M., Vekemans, J., Mshamu, S., Lang, T. A., Gould, J. H. M., Dubois, M., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0807381 · Cited by 448
The intolerable burden of malaria: a new look at the numbers
Jg, B., Egan, A. F., & Keusch, G. T. (2001) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2001.64.iv · Cited by 357
Unmet needs in modern vaccinology
Leroux-Roels, G. G. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.07.021 · Cited by 304
Malaria Vaccines: Recent Advances and New Horizons
Draper, S., Sack, B., King, C., Nielsen, C., Rayner, J., Higgins, M., Long, C. A., & Seder, R. (2018) · Cell Host and Microbe · doi:10.1016/j.chom.2018.06.008 · Cited by 299
Four-Year Efficacy of RTS,S/AS01E and Its Interaction with Malaria Exposure
Olotu, A., Fegan, G., Wambua, J., Nyangweso, G. M., Awuondo, K. O., Leach, A. J., Lievens, M., Leboulleux, D., Njuguna, P., Peshu, N. M., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1207564 · Cited by 281
Insecticide-treated nets for preventing malaria
Pryce, J., Richardson, M., & Lengeler, C. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000363.pub3 · Cited by 250
Malaria chemoprevention and drug resistance: a review of the literature and policy implications
Plowe, C. V. (2022) · Malaria Journal · doi:10.1186/s12936-022-04115-8 · Cited by 195
Increasing challenges of malaria control in sub-Saharan Africa: Priorities for public health research and policymakers
Oladipo, H. J., Tajudeen, Y. A., Oladunjoye, I. O., Yusuff, S. I., Yusuf, R. O., Egbewande, O. M., Muili, A. O., Adebisi, Y. A., & El‐Sherbini, M. S. (2022) · Annals of Medicine and Surgery · doi:10.1016/j.amsu.2022.104366 · Cited by 184
The emergence of artemisinin partial resistance in Africa: how do we respond?
Rosenthal, P. J., Asua, V., Bailey, J. A., Conrad, M. D., Ishengoma, D. S., Kamya, M. R., Rasmussen, C., Tadesse, F. G., Uwimana, A., & Fidock, D. A. (2024) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(24)00141-5 · Cited by 184
Current Status of Malaria Control and Elimination in Africa: Epidemiology, Diagnosis, Treatment, Progress and Challenges
Li, J., Docile, H. J., Fisher, D. P., Pronyuk, K., & Zhao, L. (2024) · Journal of Epidemiology and Global Health · doi:10.1007/s44197-024-00228-2 · Cited by 180
Evaluation of RTS,S/AS02A and RTS,S/AS01B in Adults in a High Malaria Transmission Area
Polhemus, M. E., Remich, S. A., Ogutu, B. R., Waitumbi, J. N., Otieno, L., Apollo, S., Cummings, J. F., Kester, K. E., Ockenhouse, C. F., Stewart, A., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006465 · Cited by 143
RTS,S: the first malaria vaccine
Zavala, F. (2022) · Journal of Clinical Investigation · doi:10.1172/jci156588 · Cited by 119
Malaria Vaccines: Progress to Date
Stanisic, D. I., & Good, M. F. (2023) · BioDrugs · doi:10.1007/s40259-023-00623-4 · Cited by 83
Seasonal vaccination with RTS,S/AS01E vaccine with or without seasonal malaria chemoprevention in children up to the age of 5 years in Burkina Faso and Mali: a double-blind, randomised, controlled, phase 3 trial
Dicko, A., Ouédraogo, J., Zongo, I., Sagara, I., Cairns, M. E., Yerbanga, R. S., Issiaka, D., Zoungrana, C., Sidibé, Y., Tapily, A., et al. (2023) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(23)00368-7 · Cited by 70
A systematic review and meta-analysis of the prevalence of caregiver acceptance of malaria vaccine for under-five children in low-income and middle-income countries (LMICs)
Sulaiman, S. K., Musa, M. S., Tsiga-Ahmed, F. I., Dayyab, F. M., Sulaiman, A. K., & Bako, A. T. (2022) · PLoS ONE · doi:10.1371/journal.pone.0278224 · Cited by 62
Phase I Clinical Trial of a Recombinant Malaria Vaccine Consisting of the Circumsporozoite Repeat Region of Plasmodium Falciparum Coupled to Hepatitis B Surface Antigen
Vreden, S., Verhave, J. P., Oettinger, T., Sauerwein, R. W., & Meuwissen, J. H. E. T. (1991) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1991.45.533 · Cited by 58
Policy uptake and implementation of the RTS,S/AS01 malaria vaccine in sub-Saharan African countries: status 2 years following the WHO recommendation
Osoro, C. B., Ochodo, E., Kwambai, T. K., Otieno, J. A., Were, L. M., Sagam, C. K., Owino, E. J., Kariuki, S., ter Kuile, F. O., & Hill, J. (2024) · BMJ Global Health · doi:10.1136/bmjgh-2023-014719 · Cited by 53
Factors associated with the risk of malaria among children: analysis of 2021 Nigeria Malaria Indicator Survey
Isiko, I., Nyegenye, S., Bett, D. K., Asingwire, J. M., Okoro, L. N., Emeribe, N. A., Koech, C. C., Ahgu, O., Bulus, N. G., Taremwa, K., et al. (2024) · Malaria Journal · doi:10.1186/s12936-024-04939-6 · Cited by 40
Assessing the safety, impact and effectiveness of RTS,S/AS01E malaria vaccine following its introduction in three sub-Saharan African countries: methodological approaches and study set-up
Praet, N., Asante, K. P., Bozonnat, M., Akité, E. J., Ansah, P. B., Baril, L., Boahen, O., Mendoza, Y. G., Haine, V., Kariuki, S., et al. (2022) · Malaria Journal · doi:10.1186/s12936-022-04144-3 · Cited by 39
Drivers of hesitancy towards recommended childhood vaccines in African settings: a scoping review of literature from Kenya, Malawi and Ethiopia
Adamu, A. A., Essoh, T.-A., Adeyanju, G. C., Jalo, R. I., Saleh, Y., Aplogan, A., & Wiysonge, C. S. (2021) · Expert Review of Vaccines · doi:10.1080/14760584.2021.1899819 · Cited by 38
RTS,S/AS01 malaria vaccine pilot implementation in western Kenya: a qualitative longitudinal study to understand immunisation barriers and optimise uptake
Hoyt, J., Okello, G. R., Bange, T., Kariuki, S., Jalloh, M. F., Webster, J., & Hill, J. (2023) · BMC Public Health · doi:10.1186/s12889-023-17194-2 · Cited by 32
Sulfadoxine/Pyrimethamine Intermittent Preventive Treatment for Malaria during Pregnancy
Deloron, P., Bertin, G. I., Briand, V., Massougbodji, A., & Cot, M. (2010) · Emerging infectious diseases · doi:10.3201/eid1611.101064 · Cited by 31
Integration of the RTS,S/AS01 malaria vaccine into the Essential Programme on Immunisation in western Kenya: a qualitative longitudinal study from the health system perspective
Hill, J., Bange, T., Hoyt, J., Kariuki, S., Jalloh, M. F., Webster, J., & Okello, G. R. (2024) · The Lancet Global Health · doi:10.1016/s2214-109x(24)00013-5 · Cited by 27
World-Wide Malaria Distribution, Prevalence, and Control
Russell, P. F. (1956) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1956.5.937 · Cited by 23
Child malaria vaccine uptake in Ghana: Factors influencing parents’ willingness to allow vaccination of their children under five (5) years
Saaka, S. A., Mohammed, K., Pienaah, C. K. A., & Luginaah, I. (2024) · PLoS ONE · doi:10.1371/journal.pone.0296934 · Cited by 22
Nigeria End Malaria Council: What to expect
Sokunbi, T. O., Omojuyigbe, J. O., Bakenne, H. A., & Adebisi, Y. A. (2022) · Annals of Medicine and Surgery · doi:10.1016/j.amsu.2022.104690 · Cited by 21
Factors associated with malaria vaccine uptake in Nsanje district, Malawi
Simbeye, A. J., Kumwenda, S., Cohee, L. M., Omondi, D., Masibo, P. K., Wao, H., & Awandu, S. S. (2024) · Malaria Journal · doi:10.1186/s12936-024-04938-7 · Cited by 21
Malaria vaccination in Africa: A mini-review of challenges and opportunities
Olawade, D. B., Wada, O. Z., Ezeagu, C. N., Aderinto, N., BALOGUN, M. A., Asaolu, F. T., & David-Olawade, A. C. (2024) · Medicine · doi:10.1097/md.0000000000038565 · Cited by 20
Ownership and usage of insecticide-treated nets in Ghana: a scoping review of facilitators and barriers
Doe, P. F., Druye, A. A., Azu, T. D., Boso, C. M., Commey, I. T., Agyare, D. F., Agyeiwaa, J., Berchie, G. O., Opoku-Danso, R., Owusu, G., et al. (2024) · Malaria Journal · doi:10.1186/s12936-024-05072-0 · Cited by 20
A review of combination adjuvants for malaria vaccines: a promising approach for vaccine development
Pirahmadi, S., Zakeri, S., Djadid, N. D., & Mehrizi, A. A. (2021) · International Journal for Parasitology · doi:10.1016/j.ijpara.2021.01.006 · Cited by 18
Implementation strategies for the introduction of the RTS,S/AS01 (RTS,S) malaria vaccine in countries with areas of highly seasonal transmission: workshop meeting report
Merle, C. S., RTSS-SMC working group, Badiane, N. A., Affoukou, C. D., Affo, S. Y., Djogbénou, L., Hounto, A. O., Kompaore, S. C. B., Ouedraogo, I., Ateba, J. M., et al. (2023) · Malaria Journal · doi:10.1186/s12936-023-04657-5 · Cited by 18
Malaria vaccine coverage estimation using age-eligible populations and service user denominators in Kenya
Moturi, A. K., Jalango, R. E., Cherono, A., Muchiri, S. K., Snow, R. W., & Okiro, E. A. (2023) · Malaria Journal · doi:10.1186/s12936-023-04721-0 · Cited by 18
Immunogenicity and safety of the RTS,S/AS01 malaria vaccine co-administered with measles, rubella and yellow fever vaccines in Ghanaian children: A phase IIIb, multi-center, non-inferiority, randomized, open, controlled trial
Asante, K. P., Ansong, D., Kaali, S., Adjei, S., Lievens, M., Badu, L. N., Agyapong, P. D., Buabeng, P. B. Y., Boahen, O., Rettig, T., et al. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.03.014 · Cited by 16
Bridging the gap to malaria vaccination in Africa: Challenges and opportunities
Okesanya, O. J., Atewologun, F. A., Lucero‐Prisno, D. E., Adigun, O. A., Oso, T. A., Manirambona, E., Olaleke, N. O., Eshun, G., Agboola, A. O., & Okon, I. I. (2024) · Journal of Medicine Surgery and Public Health · doi:10.1016/j.glmedi.2024.100059 · Cited by 13
Impact of exposure to malaria and nutritional status on responses to the experimental malaria vaccine ChAd63 MVA ME-TRAP in 5-17 month-old children in Burkina Faso
Morter, R., Tiono, A. B., Nébié, I., Hague, O., Ouédraogo, A., Diarra, A., Viebig, N. K., Hill, A. V. S., Ewer, K., & Sirima, S. B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1058227 · Cited by 10
Developing a human malaria sporozoite vaccine
Young, J. F., Ballou, W. R., & Hockmeyer, W. T. (1987) · Microbial Pathogenesis · doi:10.1016/0882-4010(87)90121-5 · Cited by 8
Impact of high human genetic diversity in Africa on immunogenicity and efficacy of RTS,S/AS01 vaccine
Tukwasibwe, S., Mboowa, G., Sserwadda, I., Nankabirwa, J. I., Arinaitwe, E., Ssewanyana, I., Taremwa, Y., Tumusiime, G., Kamya, M. R., Jagannathan, P., et al. (2023) · Immunogenetics · doi:10.1007/s00251-023-01306-8 · Cited by 8
Impact of Pyrethroid Plus Piperonyl Butoxide Synergist-Treated Nets on Malaria Incidence 24 Months after a National Distribution Campaign in Rwanda
Kabera, M., Mangala, J.-L. N., Soebiyanto, R. P., Mukarugwiro, B., Munguti, K., Mbituyumuremyi, A., Lucchi, N. W., & Hakizimana, E. (2023) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.23-0317 · Cited by 8
Routine malaria vaccinations start in Africa
Venkatesan, P. (2024) · The Lancet Microbe · doi:10.1016/s2666-5247(24)00073-9 · Cited by 8
Prevention of Malaria in Pregnancy: What Do the Pregnant Women of Nigeria Know and Do about It?
Kalu, S. O., Cleenewerck, L., Gulma, K. A., & Bhalla, D. (2022) · Infectious Diseases in Obstetrics and Gynecology · doi:10.1155/2022/7061548 · Cited by 5
Brugada syndrome following febrile episode caused by malarial infection: a case report
Aryal, E., Mainali, A., & Aryal, S. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002286 · Cited by 1

Research works printed but not linked: 5

WHO guidelines for malaria [Internet]. Geneva: World Health Organization: https://www.ncbi.nlm.nih.gov/books/NBK588130/. Accessed 16 Feb 2021
Ndeketa L, Mategula D, Terlouw DJ, Bar-Zeev N, Sauboin CJ, Biernaux S. Cost-effectiveness and public health impact of RTS, S/AS01 E malaria vaccine in Malawi, using a Markov static model. Welcome Open Res. 2021. https://doi.org/10.1268/wellcomeopenres.16224.2. · DOI
Mutombo AM, Mukuku O, Tshibanda KN, et al. Severe malaria and death risk factors among children under 5 years at Jason Sendwe hospital in democratic republic of Congo. Pan Afr Med J. 2018. https://doi.org/10.1160/pamj.2018.29.184.15235. · DOI
Hotez PJ. Vaccine preventable disease and vaccine hesitancy. Med Clin North Am. 2023;107(6):979–87. https://doi.org/10.1016/j.mcna.2023.05.01. · DOI
World Health Organization. Seasonal malaria chemoprevention with sulfadoxine–pyrimethamine plus amodiaquine in children: a field guide. Geneva: World Health Organization; 2023.

Sorted by citations

Current update on malaria in pregnancy: a systematic review
Minwuyelet, A., Yewhalaw, D., Siferih, M., & Atenafu, G. (2025) · Tropical Diseases, Travel Medicine and Vaccines · doi:10.1186/s40794-025-00248-1 · Cited by 49
The burden of malaria in East Africa: prevalence, risk factors, and control strategies
Bashir, S., Ahmed, N. I., Abdullahi, Y. B., Abdi, Y. H., Abdi, M. S., & Musa, M. K. (2025) · Malaria Journal · doi:10.1186/s12936-025-05492-6 · Cited by 19
Malaria in the 21st Century: Global Disease Burden, Epidemiological Insights, and Strategic Control Approaches
Alharbi, B. F., & Ahmed, M. (2026) · Biology · doi:10.3390/biology15070575 · Cited by 14
Experimental plasmonic sensing of malaria using an aluminum metasurface
Kiyumbi, A. S., & Tame, M. (2026) · Nanoscale Advances · doi:10.1039/d5na01083g · Cited by 7
Safety of RTS,S/AS01E vaccine for malaria in African children aged 5 to 17 months: A systematic review and meta-analysis of randomized controlled trials
Bindzi, J. B. A. Z., Linjouom, R.-M. N., Ndongo, M. N., & Nkeck, J. R. (2025) · PLOS Global Public Health · doi:10.1371/journal.pgph.0004387 · Cited by 5

See all 13

Authors: Ogieuhi, I. J., Ajekiigbe, V. O., Kolo-Manma, K., Akingbola, A., Odeniyi, T. A., Soyemi, T. S., Ayomide, J. H., Thiyagarajan, B., & Awolola, B. D.
Affiliations: Siberian State Medical University (RU)
Ladoke Akintola University of Technology (NG)
University of Cambridge (GB)
Far Eastern Federal University (RU)
Bowen University (NG)
Corresponding author: Ogieuhi, Ikponmwosa Jude
ORCID: Ogieuhi, Ikponmwosa Jude
Akingbola, Adewunmi
Venue: Discover Public Health
Publisher: Springer Science and Business Media LLC
Published: 2024-10-25
Volume: 21
Issue: 1
ISSN: 3005-0774 (ISSN-L)
DOI: 10.1186/s12982-024-00284-w
OpenAlex: W4403770875
Cited by: 13
References: 45
Citations by year: 2026: 7 · 2025: 6
FWCI: 1.15
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by-nc-nd
creativecommons.org/licenses/by-nc-nd/4.0 (tdm)
creativecommons.org/licenses/by-nc-nd/4.0 (vor)
Locations: Discover Public Health (publishedVersion, cc-by-nc-nd)
Apollo (University of Cambridge) (submittedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
Social Sciences › Health › Vaccine Coverage and Hesitancy
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Travel-related health issues
Keywords: RTS,S/AS01 vaccine, malaria vaccine, vaccine implementation, vaccine effectiveness, vaccine uptake, vaccine financing, insecticide-treated nets, antimalarial drugs, pilot project, malaria eradication

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

A narrative review of the RTS S AS01 malaria vaccine and its implementation in Africa to reduce the global malaria burden

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks