The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
A narrative review of the RTS S AS01 malaria vaccine and its implementation in Africa to reduce the global malaria burden
Open accessAbstract
The RTS, S/AS01 vaccine is a significant milestone in advancing malaria control, especially in Africa, where the heavy burden of this disease is prevalent. The objective of this study is to discuss the effectiveness and utilization of the RTS, S/AS01 vaccine in Africa while simultaneously addressing the gaps and associated issues. We also explore briefly the R21/Matrix-M vaccines recommended by the World Health Organization (WHO) for children aged five months and older. Essential considerations include but are not limited to the vaccine's effectiveness, implementation challenges, available funding sources, public acceptance, and compatibility with various conventional prevention methods for malaria, like insecticide-coated bed nets and antimalarial medicines. This paper also examines the global practices for integrating vaccines into public health systems and policies while emphasizing sustainable and equitable approaches. By drawing from the lessons learned from the implementations of pilot programs as well as early adoption of the RTS, S/AS01 malaria vaccine, this perspective study tries to identify the key factors that may enhance the impact of the vaccine in the fight against malaria and significantly contribute to the vision of complete eradication the disease. Further research needs to be carried out regarding the efficacy and duration of protection of the RTS, S/AS01 vaccine.
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“There are no other vaccines available at this time for the prevention of malaria in pregnancy, apart from RTS, S, which is used in malaria-endemic regions, particularly during the second or third trimester of pregnancy [218, 219].”
From Current update on malaria in pregnancy: a systematic review (2025) · cites this paper as [219]
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“Currently, RTS, S/AS01 (RTS, S) is the only malaria vaccine specifically recommended for use in pregnant women.”
From Current update on malaria in pregnancy: a systematic review (2025) · cites this paper as [219]
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Citations
Cites
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RTS,S/AS01 vaccine (Mosquirix™): an overview
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Four-Year Efficacy of RTS,S/AS01E and Its Interaction with Malaria Exposure
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Cited by
Sorted by citations
Current update on malaria in pregnancy: a systematic review
Minwuyelet, A., Yewhalaw, D., Siferih, M., & Atenafu, G. (2025) · Tropical Diseases, Travel Medicine and Vaccines · doi:10.1186/s40794-025-00248-1 · Cited by 49
The burden of malaria in East Africa: prevalence, risk factors, and control strategies
Bashir, S., Ahmed, N. I., Abdullahi, Y. B., Abdi, Y. H., Abdi, M. S., & Musa, M. K. (2025) · Malaria Journal · doi:10.1186/s12936-025-05492-6 · Cited by 19
Alharbi, B. F., & Ahmed, M. (2026) · Biology · doi:10.3390/biology15070575 · Cited by 14
Experimental plasmonic sensing of malaria using an aluminum metasurface
Kiyumbi, A. S., & Tame, M. (2026) · Nanoscale Advances · doi:10.1039/d5na01083g · Cited by 7
Bindzi, J. B. A. Z., Linjouom, R.-M. N., Ndongo, M. N., & Nkeck, J. R. (2025) · PLOS Global Public Health · doi:10.1371/journal.pgph.0004387 · Cited by 5
Metadata
- Authors
- Ogieuhi, I. J., Ajekiigbe, V. O., Kolo-Manma, K., Akingbola, A., Odeniyi, T. A., Soyemi, T. S., Ayomide, J. H., Thiyagarajan, B., & Awolola, B. D.
- Affiliations
- Siberian State Medical University (RU)
- Ladoke Akintola University of Technology (NG)
- University of Cambridge (GB)
- Far Eastern Federal University (RU)
- Bowen University (NG)
- Corresponding author
- Ogieuhi, Ikponmwosa Jude
- Venue
- Discover Public Health
- Published
- 2024-10-25
- Volume
- 21
- Issue
- 1
- ISSN
- 3005-0774 (ISSN-L)
- OpenAlex
- W4403770875
- Cited by
- 13
- References
- 45
- Citations by year
- 2026: 7 · 2025: 6
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Discover Public Health (publishedVersion, cc-by-nc-nd)
- Apollo (University of Cambridge) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Travel-related health issues
- Keywords
- RTS,S/AS01 vaccine, malaria vaccine, vaccine implementation, vaccine effectiveness, vaccine uptake, vaccine financing, insecticide-treated nets, antimalarial drugs, pilot project, malaria eradication
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