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Cited by 7Neurotransmitter Receptor Influence on BehaviorAttention Deficit Hyperactivity DisorderChild and Adolescent Psychosocial and Emotional Development

Association of tryptophan hydroxylase-2 polymorphisms with oppositional defiant disorder in a Chinese Han population

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Wang, Chang-Hong, Liu, Cong, Cong, En-Zhao, Xu, Gai-Ling, Lv, Ting-Ting, Zhang, Ying-Li, Ning, Qiu-Fen, Wang, Ji-Kang +2 more·2016·Behavioral and Brain Functions
DOI 10.1186/s12993-016-0113-0PMC PMC5117514
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Abstract

BACKGROUND: Oppositional defiant disorder (ODD) is a behavioral disorder of school-age population. It is well known that 5-HT dysfunction is correlated with impulsivity, which is one of the common characteristics of ODD. The enzyme tryptophan hydroxylase-2 (TPH-2) synthesizes 5-HT in serotonergic neurons of the midbrain raphe. The purposes of this study were to investigate the potential association of TPH-2 polymorphisms with susceptibility to ODD in a Han Chinese school population. METHODS: Four polymorphisms (rs4570625, rs11178997, rs1386494 and rs7305115) of the TPH-2 gene were analyzed by using polymerase chain reaction and DNA microarray hybridization in a case-control study of 276 Han Chinese individuals (124 ODD and 152 controls). RESULTS: = 3.930, P = 0.047) of rs1386494 between ODD and control groups. Haplotype analyses revealed higher frequencies of haplotypes TA (rs4570625-rs11178997), TAG (rs4570625-rs11178997-rs1386494), TAA (rs4570625-rs11178997-rs7305115) and TAGA (rs4570625-rs11178997-rs1386494-rs7305115), but lower frequencies of haplotypes GA (rs4570625-rs11178997) and GAG (rs4570625-rs11178997-rs1386494) in ODD compared to control groups. CONCLUSIONS: These findings suggest the role of these TPH-2 gene variants in susceptibility to ODD. Some haplotypes might be the risk factors for Chinese Han children with ODD, while others might be preventable factors.

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  • Serotonin dysfunction plays a mediator role in ADHD-related hyperactive and impulsive behaviours, inducing impaired control of impulses, violent behaviour, concentration and appetite.

    “Serotonin dysfunction plays a mediator role in ADHD-related hyperactive and impulsive behaviours [91] inducing impaired control of impulses, violent behaviour, concentration and appetite [89].”

    From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [91]

    The citation [91] is attached to the first clause; the later list of effects is cited to [89]. The Background says serotonin dysfunction is correlated with impulsivity, a characteristic of ADHD, and the Discussion links reduced serotonin activity to impulsive behavior. Neither passage establishes a mediating role or specifically links serotonin dysfunction to ADHD-related hyperactivity. (LLM, conf=0.85)

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Authors
Wang, C.-H., Liu, C., Cong, E.-Z., Xu, G.-L., Lv, T.-T., Zhang, Y.-L., Ning, Q.-F., Wang, J.-K., Nie, H.-Y., & Li, Y.
Affiliations
  • Henan Psychiatric Hospital (CN)
  • Zhengzhou University (CN)
Corresponding author
  • Nie, Hui-Yao
  • Li, Yan
ORCID
Li, Yan
Venue
Behavioral and Brain Functions
Publisher
Springer Science and Business Media LLC
Published
2016-11-21
Volume
12
Issue
1
Pages
30-30
ISSN
1744-9081 (ISSN-L)
DOI
10.1186/s12993-016-0113-0
PMC
PMC5117514
OpenAlex
W2549876459
Cited by
7
References
53
Citations by year
2026: 2 · 2024: 1 · 2022: 1 · 2019: 1 · 2018: 2
FWCI
0.56
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Behavioral and Brain Functions (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • Medical Technology Foundation of Henan Province (142300410025, 112102310211)
  • Scientific Research Fund of Xinxiang Medical University (2013ZD117)
  • Ministry of Health research fund projects in China (20090103)
  • Henan Provincial Department of Science and Technology Research Project (102101310400)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
oppositional defiant disorder, tryptophan hydroxylase 2, serotonin, serotonergic system, genetic susceptibility, haplotypes, Han Chinese children, elementary school students, impulsivity
MeSH terms
Adolescent, Child, China, Ethnicity, Female, Gene Frequency, Haplotypes, Humans, Male, Tryptophan Hydroxylase, Linkage Disequilibrium, Case-Control Studies, Attention Deficit and Disruptive Behavior Disorders, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Asian People, Genetic Association Studies

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