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Protocol: Adaptive Implementation of Effective Programs Trial (ADEPT): cluster randomized SMART trial comparing a standard versus enhanced implementation strategy to improve outcomes of a mood disorders program
Open accessAbstract
BACKGROUND: Despite the availability of psychosocial evidence-based practices (EBPs), treatment and outcomes for persons with mental disorders remain suboptimal. Replicating Effective Programs (REP), an effective implementation strategy, still resulted in less than half of sites using an EBP. The primary aim of this cluster randomized trial is to determine, among sites not initially responding to REP, the effect of adaptive implementation strategies that begin with an External Facilitator (EF) or with an External Facilitator plus an Internal Facilitator (IF) on improved EBP use and patient outcomes in 12 months. METHODS/DESIGN: This study employs a sequential multiple assignment randomized trial (SMART) design to build an adaptive implementation strategy. The EBP to be implemented is life goals (LG) for patients with mood disorders across 80 community-based outpatient clinics (N = 1,600 patients) from different U.S. regions. Sites not initially responding to REP (defined as < 50% patients receiving ≥ 3 EBP sessions) will be randomized to receive additional support from an EF or both EF/IF. Additionally, sites randomized to EF and still not responsive will be randomized to continue with EF alone or to receive EF/IF. The EF provides technical expertise in adapting LG in routine practice, whereas the on-site IF has direct reporting relationships to site leadership to support LG use in routine practice. The primary outcome is mental health-related quality of life; secondary outcomes include receipt of LG sessions, mood symptoms, implementation costs, and organizational change. DISCUSSION: This study design will determine whether an off-site EF alone versus the addition of an on-site IF improves EBP uptake and patient outcomes among sites that do not respond initially to REP. It will also examine the value of delaying the provision of EF/IF for sites that continue to not respond despite EF. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT02151331.
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“In a subsequent study, Kilbourne et al. (2014) are using SMART to examine an adaptive version of REP (64).”
From An Overview of Research and Evaluation Designs for Dissemination and Implementation (2017) · cites this paper as [64]
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An introduction to implementation science for the non-specialist
Bauer, M. S., Damschroder, L. J., Hagedorn, H., Smith, J. L., & Kilbourne, A. M. (2015) · BMC Psychology · doi:10.1186/s40359-015-0089-9 · Cited by 2,168
Self-citationEnhancing the Impact of Implementation Strategies in Healthcare: A Research Agenda
Powell, B. J., Fernandez, M. E., Williams, N. J., Aarons, G. A., Beidas, R. S., Lewis, C. C., McHugh, S. M., & Weiner, B. J. (2019) · Frontiers in Public Health · doi:10.3389/fpubh.2019.00003 · Cited by 775
Implementation science should give higher priority to health equity
Brownson, R. C., Kumanyika, S., Kreuter, M. W., & Haire-Joshu, D. L. (2021) · Implementation Science · doi:10.1186/s13012-021-01097-0 · Cited by 585
An Overview of Research and Evaluation Designs for Dissemination and Implementation
Brown, C. H., Curran, G., Palinkas, L. A., Aarons, G. A., Wells, K. B., Jones, L., Collins, L. M., Duan, N., Mittman, B. S., Wallace, A., et al. (2017) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-031816-044215 · Cited by 509
World Health Organization disability assessment schedule 2.0: An international systematic review
Federici, S., Bracalenti, M., Meloni, F., & Luciano, J. V. (2016) · Disability and Rehabilitation · doi:10.1080/09638288.2016.1223177 · Cited by 542
Metadata
- Authors
- Kilbourne, A. M., Almirall, D., Eisenberg, D., Waxmonsky, J., Goodrich, D. E., Fortney, J. C., Kirchner, J. E., Solberg, L. I., Main, D., Bauer, M. S., Kyle, J., Murphy, S. A., Nord, K. M., & Thomas, M. R.
- Affiliations
- VA Ann Arbor Healthcare System (US)
- University of Michigan (US)
- University of Colorado Anschutz (US)
- Health Services Research & Development (US)
- Quality Enhancement Research Initiative (US)
- HealthPartners (US)
- University of Colorado Denver (US)
- VA Boston Healthcare System (US)
- Corresponding author
- Kilbourne, Amy M
- ORCID
- Venue
- Implementation Science
- Published
- 2014-09-30
- Volume
- 9
- Issue
- 1
- Pages
- 132-132
- ISSN
- 1748-5908 (ISSN-L)
- PMC
- PMC4189548
- OpenAlex
- W1972388887
- Cited by
- 130
- References
- 143
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 20 · 2023: 14 · 2022: 25 · 2021: 12 · 2020: 14 · 2019: 10 · 2018: 8 · 2017: 8 · 2016: 5 · 2015: 3
- FWCI
- 9.63
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Implementation Science (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- U.S. Public Health Service (R01 099898)
- National Institute of Mental Health (R01MH099898)
- National Institute on Drug Abuse (P50DA010075)
- Topics
- Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
- Social Sciences › Psychology › Clinical Psychology › Psychiatric care and mental health services
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Keywords
- evidence-based practice uptake, mood disorders, external facilitators, community-based outpatient clinics, mental health-related quality of life, implementation costs, organizational change, sequential multiple assignment randomized trial, ADEPT
- MeSH terms
- Community Mental Health Services, Humans, Program Development, Evidence-Based Medicine, Mood Disorders, Quality Improvement, Patient Outcome Assessment
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