Plant metabolomics: a new strategy and tool for quality evaluation of Chinese medicinal materials

Xiao, Qi; Mu, Xinlu; Liu, Jiushi; Li, Bin; Liu, Haitao; Zhang, Bengang; Xiao, Peigen

doi:10.1186/s13020-022-00601-y

Cited by 104Traditional Chinese Medicine AnalysisMetabolomics and Mass Spectrometry StudiesPhytochemistry and Biological Activities

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Plant metabolomics: a new strategy and tool for quality evaluation of Chinese medicinal materials

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Xiao, Qi, Mu, Xinlu, Liu, Jiushi, Li, Bin, Liu, Haitao, Zhang, Bengang, Xiao, Peigen·2022·Chinese Medicine

DOI 10.1186/s13020-022-00601-yPMC PMC8990502

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Abstract

The present quality control method of Chinese medicinal materials (CMM) has obvious deficiency, which cannot be compatible with the multi-target and multi-component characteristics and production process of CMM. Plant metabolomics with a huge impetus to comprehensively characterize the metabolites and clarify the complexity and integrity of CMM, has been widely used in the research of CMM. This article comprehensively reviewed the application of plant metabolomics in the quality control of CMM. It introduced the concept, technique, and application examples, discussed the prospects, limitations, improvements of plant metabolomics. MS and NMR, as important techniques for plant metabolomics, are mainly highlighted in the case references. The purpose of this article is to clarify the advantage of plants metabolomics for promoting the optimization of the CMM quality control system and proposing a system approach to realize the overall quality control of CMM based on plant metabolomics combined with multidisciplinary method.

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Untargeted metabolomics-based methods can identify geographical origin, species, and variety-specific variations.
“This includes the use of untargeted metabolomics-based methods to identify geographical origin, species, and variety-specific variations [11,12].”
From Rapid metabolic fingerprinting with the aid of chemometric models to identify authenticity of natural medicines: Turmeric, Ocimum, and Withania somnifera study (2023) · cites this paper as [12]
The Herbal source section describes metabolomics-based species identification and metabolite differences among geographical regions; Herbal marketing describes chemical differences among five Rhodiola varieties. The paper does not establish that the methods used for all three distinctions were untargeted: its explicit untargeted examples concern other applications, including adulteration detection. (LLM, conf=0.83)
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Authors: Xiao, Q., Mu, X., Liu, J., Li, B., Liu, H., Zhang, B., & Xiao, P.
Affiliations: Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Corresponding author: Liu, Haitao
ORCID: Mu, Xinlu
Liu, Jiushi
Li, Bin
Liu, Haitao
Zhang, Bengang
Venue: Chinese Medicine
Publisher: Springer Science and Business Media LLC
Published: 2022-04-08
Volume: 17
Issue: 1
Pages: 45-45
ISSN: 1749-8546 (ISSN-L)
DOI: 10.1186/s13020-022-00601-y
PMC: PMC8990502
OpenAlex: W4223445632
Cited by: 104
References: 102
Citations by year: 2026: 22 · 2025: 23 · 2024: 29 · 2023: 23 · 2022: 7
FWCI: 4.75
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Chinese Medicine (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: the ability establishment of sustainable use for valuable Chinese medicine resources (2060302-2002-05)
the National Natural Science Foundation of China (81872965)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Keywords: plant metabolomics, Chinese materia medica, quality control, metabolite profiling, mass spectrometry, NMR spectroscopy

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Plant metabolomics: a new strategy and tool for quality evaluation of Chinese medicinal materials

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