Cited by 104Traditional Chinese Medicine AnalysisMetabolomics and Mass Spectrometry StudiesPhytochemistry and Biological Activities

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Plant metabolomics: a new strategy and tool for quality evaluation of Chinese medicinal materials

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Xiao, Qi, Mu, Xinlu, Liu, Jiushi, Li, Bin, Liu, Haitao, Zhang, Bengang, Xiao, Peigen·2022·Chinese Medicine

DOI 10.1186/s13020-022-00601-yPMC PMC8990502

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Abstract

The present quality control method of Chinese medicinal materials (CMM) has obvious deficiency, which cannot be compatible with the multi-target and multi-component characteristics and production process of CMM. Plant metabolomics with a huge impetus to comprehensively characterize the metabolites and clarify the complexity and integrity of CMM, has been widely used in the research of CMM. This article comprehensively reviewed the application of plant metabolomics in the quality control of CMM. It introduced the concept, technique, and application examples, discussed the prospects, limitations, improvements of plant metabolomics. MS and NMR, as important techniques for plant metabolomics, are mainly highlighted in the case references. The purpose of this article is to clarify the advantage of plants metabolomics for promoting the optimization of the CMM quality control system and proposing a system approach to realize the overall quality control of CMM based on plant metabolomics combined with multidisciplinary method.

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Fig. 1 Comparison of existing CMM quality control system and metabolomics methodsCC BY · PubMed Central

Fig. 2 Process, technology and methods of plant metabolomics: A The process of plant metabolomics. B Contents included in the data processing [111–113]. C The classification of multivariate statistical methods and figure of PCA and OPLS-DA [114–118]CC BY · PubMed Central

Fig. 3 The application of plant metabolomics in the quality control of CMMCC BY · PubMed Central

Fig. 4 Schematic diagram of experimental steps of plant metabolomic in quality evaluation of CMMCC BY · PubMed Central

Fig. 5 Schematic diagram of multi-disciplinary application based on plant metabolomics to establish a comprehensive CMM quality control systemCC BY · PubMed Central

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Method
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See all 104

Authors: Xiao, Q., Mu, X., Liu, J., Li, B., Liu, H., Zhang, B., & Xiao, P.
Affiliations: Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Corresponding author: Liu, Haitao
ORCID: Mu, Xinlu
Liu, Jiushi
Li, Bin
Liu, Haitao
Zhang, Bengang
Venue: Chinese Medicine
Publisher: Springer Science and Business Media LLC
Published: 2022-04-08
Volume: 17
Issue: 1
Pages: 45-45
ISSN: 1749-8546 (ISSN-L)
DOI: 10.1186/s13020-022-00601-y
PMC: PMC8990502
OpenAlex: W4223445632
Cited by: 104
References: 102
Citations by year: 2026: 22 · 2025: 23 · 2024: 29 · 2023: 23 · 2022: 7
FWCI: 4.75
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0 (tdm)
creativecommons.org/licenses/by/4.0 (vor)
Locations: Chinese Medicine (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: the ability establishment of sustainable use for valuable Chinese medicine resources (2060302-2002-05)
the National Natural Science Foundation of China (81872965)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Keywords: plant metabolomics, Chinese materia medica, quality control, metabolite profiling, mass spectrometry, NMR spectroscopy

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Plant metabolomics: a new strategy and tool for quality evaluation of Chinese medicinal materials

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