The DOI matches its Crossref record; 101 of the 102 references it cites were found in a registry or an index.
Plant metabolomics: a new strategy and tool for quality evaluation of Chinese medicinal materials
Open accessAbstract
The present quality control method of Chinese medicinal materials (CMM) has obvious deficiency, which cannot be compatible with the multi-target and multi-component characteristics and production process of CMM. Plant metabolomics with a huge impetus to comprehensively characterize the metabolites and clarify the complexity and integrity of CMM, has been widely used in the research of CMM. This article comprehensively reviewed the application of plant metabolomics in the quality control of CMM. It introduced the concept, technique, and application examples, discussed the prospects, limitations, improvements of plant metabolomics. MS and NMR, as important techniques for plant metabolomics, are mainly highlighted in the case references. The purpose of this article is to clarify the advantage of plants metabolomics for promoting the optimization of the CMM quality control system and proposing a system approach to realize the overall quality control of CMM based on plant metabolomics combined with multidisciplinary method.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
![Fig. 2 Process, technology and methods of plant metabolomics: A The process of plant metabolomics. B Contents included in the data processing [111–113]. C The classification of multivariate statistical methods and figure of PCA and OPLS-DA [114–118]](/paper-figures/9b7b2740e0034604b732b222d1c90388/plant-metabolomics-a-new-strategy-and-tool-for-quality-evaluation-of-chinese-figure-2.jpg)
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This includes the use of untargeted metabolomics-based methods to identify geographical origin, species, and variety-specific variations [11,12].”
From Rapid metabolic fingerprinting with the aid of chemometric models to identify authenticity of natural medicines: Turmeric, Ocimum, and Withania somnifera study (2023) · cites this paper as [12]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mass spectrometry‐based metabolomics
Dettmer, K., Aronov, P. A., & Hammock, B. D. (2006) · Mass Spectrometry Reviews · doi:10.1002/mas.20108 · Cited by 2,379
The future of NMR-based metabolomics
Markley, J. L., Brüschweiler, R., Edison, A. S., Eghbalnia, H. R., Powers, R., Raftery, D., & Wishart, D. S. (2016) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2016.08.001 · Cited by 918
Standardization of herbal medicines - A review
Kunle (2012) · International Journal of Biodiversity and Conservation · doi:10.5897/ijbc11.163 · Cited by 737
Triba, M. N., Moyec, L. L., Amathieu, R., Goossens, C., Bouchemal, N., Nahon, P., Rutledge, D. N., & Savarin, P. (2014) · Molecular BioSystems · doi:10.1039/c4mb00414k · Cited by 709
Applications of Fourier transform-infrared spectroscopy to edible oils
Vlachos, N., Skopelitis, Y., Psaroudaki, M., Konstantinidou, V., Chatzilazarou, A., & Tegou, E. (2006) · Analytica Chimica Acta · doi:10.1016/j.aca.2006.05.034 · Cited by 700
Metabolomics: applications to food science and nutrition research
Wishart, D. S. (2008) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2008.03.003 · Cited by 694
Advantages of application of UPLC in pharmaceutical analysis
Nováková, L., Matysová, L., & Solich, P. (2005) · Talanta · doi:10.1016/j.talanta.2005.06.035 · Cited by 463
Boccard, J., & Rutledge, D. N. (2013) · Analytica Chimica Acta · doi:10.1016/j.aca.2013.01.022 · Cited by 392
High-resolution magic-angle-spinning NMR spectroscopy for metabolic profiling of intact tissues
Beckonert, O. P., Coen, M., Keun, H. C., Wang, Y., Ebbels, T. M. D., Holmes, E. C., Lindon, J. C., & Nicholson, J. K. (2010) · Nature Protocols · doi:10.1038/nprot.2010.45 · Cited by 388
Sample preparation for plant metabolomics
Kim, H. K., & Verpoorte, R. (2009) · Phytochemical Analysis · doi:10.1002/pca.1188 · Cited by 372
Research works printed but not linked: 16
- Liu ZJ. Innovation and development of quality control and evaluation pattern of CMM. Clin J Chin Med. 2014;89:567.
- Chunmei LU, Cui X. Research Progress in TCM Quality Control and Toxicity Evaluation Based on Metabolomics Technology. Chin J Inform Tradit Chin Med. 2019;8:78.
- Tu XM, Wu H, Wu KY. Research and Application on Traditional Chinese Medicine Fingerprint. Strait Pharma J. 2016;9:7.
- Xie PS. A Feasible Strategy for Applying Chromatography Fingerprint to Assess Quality of Chinese Herbal Medicine. Tradit Chin Drug Res Clin Pharmacol. 2001;98:6799.
- Liu Y, Yu B, Pang N, Liao Y, Liu H. Applications of LC-MS and CE-MS in the analysis of traditional Chinese medicine. Sciencepaper Online. 2009;89:6.
- Alessia V, Veronica G, Gaia M, Cristina L, Takis PG, Leonardo T, Paola T, Claudio L. High-throughput metabolomics by 1D NMR. Angew Chem Int Ed. 2018;8:243.
- Liu CX. Recognizing healthy development of Chinese medicine industry from resourcesquality-quality markers of Chinese medicine. Chin Tradition Herb Drugs. 2016;47:3149–54.
- Yang X, Jia S, Zhan W. Study on Quality Influencing Factor and Preparation of CMM Hard Capsules. Western J Tradit Chin Med. 2013;98:5682.
- Shihao, H.U., Xinyue, Y.U., Ruiting, L.I., Xiaoxia, W.U., Yang, X., Han, Z., Huang, Y., Department, P. Analysis of the differential compounds in Astragalus membranaceus from different geographical origins by UFLC-IT-TOF/MS. J China Pharma Univer. 2019;89:78.
- Hussain K, Ismail Z, Sadikun A, Ibrahim P. Evaluation of Metabolic Changes in Fruit of Piper Sarmentosum in Various Seasons by Metabolomics Using Fourier Transform Infrared (FTIR) Spectroscopy. Int J Pharm Clin Res. 2009;1(2):68–71.
- Chen, J.K., Zeng, R., University, S.M. Application of metabolomics approach to study on chemical constituents in different parts of Gentiana crasicaulis based on UPLC-ESI-HRMS~n. Chin Tradit Herbal Drugs. 2018;49(10):2328–35.
- Meng Y, Peng WU, Zhang XL, Jiang HQ, Hui-Fen LI, Zhang QQ, Wang JX. Rapid Identification of Chemical Components in Raw and Processed Products of Polygalae Radix by HPLC-TOF/MS. Chin J Exp Tradit Med Formulae. 2015;34:5.
- Su X, Wu Y, Li Y, Huang Y, Liu Y, Luo P, Zhang Z. Molecules. 2019;24:17.
- Tokimatsu T, Sakurai N, Suzuki H, Shibata D. KaPPA-View: A Tool for Integrating Transcriptomic and Metabolomic Data on Plant Metabolic Pathway Maps. Biotechnol Agric For. 2006;57:209.
- Acharya S, Hedda GV, Kankariya AJ, et al. Hairy roots of ‘dashmula’ plant Uraria picta as a promising alternative to its medicinally valued true roots - functional and metabolomic analysis. Plant Cell Tiss Organ Cult. 2021;145:533–44. · DOI
- Andreev, V.P., Rejtar, T., Karger, B.L., Matched Filtration with Experimental Noise Determination for Denoising, Peak Picking and Quantitation in LC-MS (MEND).
Cited by
Sorted by citations
Current Trends in Toxicity Assessment of Herbal Medicines: A Narrative Review
Jităreanu, A., Trifan, A., Vieriu, M., Caba, I.-C., Mârţu, I., & Agoroaei, L. (2022) · Processes · doi:10.3390/pr11010083 · Cited by 166
Astragali radix (Huangqi): a time-honored nourishing herbal medicine
Zhang, Y., Chen, Z., Chen, L., Dong, Q., Yang, D., Zhang, Q., Zeng, J., Wang, Y., Liu, X., Yuan, C., et al. (2024) · Chinese Medicine · doi:10.1186/s13020-024-00977-z · Cited by 77
Multi-Omics Techniques for Soybean Molecular Breeding
Cao, P., Zhao, Y., Wu, F., Xin, D., Liu, C., Wu, X., Lv, J. C., Chen, Q., & Qi, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094994 · Cited by 58
Khan, S., Rai, A. K., Singh, A., Singh, S., Dubey, B. K., Lal, R. K., Negi, A. S., Birse, N., Trivedi, P. K., Elliott, C. T., et al. (2023) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.04.018 · Cited by 34
“This includes the use of untargeted metabolomics-based methods to identify geographical origin, species, and variety-specific variations [11,12].”
MethodWu, J., Deng, S., Yu, X., Wu, Y. S., Hua, X., Zhang, Z., & Huang, Y. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155201 · Cited by 33
Metadata
- Authors
- Xiao, Q., Mu, X., Liu, J., Li, B., Liu, H., Zhang, B., & Xiao, P.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Corresponding author
- Liu, Haitao
- Venue
- Chinese Medicine
- Published
- 2022-04-08
- Volume
- 17
- Issue
- 1
- Pages
- 45-45
- ISSN
- 1749-8546 (ISSN-L)
- PMC
- PMC8990502
- OpenAlex
- W4223445632
- Cited by
- 104
- References
- 102
- Citations by year
- 2026: 22 · 2025: 23 · 2024: 29 · 2023: 23 · 2022: 7
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Chinese Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- the ability establishment of sustainable use for valuable Chinese medicine resources (2060302-2002-05)
- the National Natural Science Foundation of China (81872965)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- plant metabolomics, Chinese materia medica, quality control, metabolite profiling, mass spectrometry, NMR spectroscopy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
