The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Functions of lncRNA HOTAIR in lung cancer
Open accessAbstract
Long non-coding RNAs (lncRNAs) govern fundamental biochemical and cellular processes. lncRNA HOX transcript antisense RNA (HOTAIR) represses gene expression through recruitment of chromatin modifiers. The expression of HOTAIR is elevated in lung cancer and correlates with metastasis and poor prognosis. Moreover, HOTAIR promotes proliferation, survival, invasion, metastasis, and drug resistance in lung cancer cells. Here we review the molecular mechanisms underlying HOTAIR-mediated aggressive phenotypes of lung cancer. We also discuss HOTAIR's potential in diagnosis and treatment of lung cancer, as well as the challenges of exploiting HOTAIR for intervention of lung cancer.
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Cited by
MALAT1: a druggable long non-coding RNA for targeted anti-cancer approaches
Amodio, N., Raimondi, L., Juli, G., Stamato, M. A., Caracciolo, D., Tagliaferri, P., & Tassone, P. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0606-4 · Cited by 348
Hua, Q., Jin, M., Mi, B., Xu, F., Li, T., Zhao, L., Liu, J., & Huang, G. (2019) · Journal of Hematology & Oncology · doi:10.1186/s13045-019-0773-y · Cited by 267
Metadata
- Authors
- Loewen, G., Jayawickramarajah, J., Zhuo, Y., & Shan, B.
- Venue
- Journal of Hematology & Oncology
- Published
- 2014-12
- Volume
- 7
- Issue
- 1
- Pages
- 90-90
- ISSN
- 1756-8722 (ISSN-L)
- OpenAlex
- W2119043602
- Cited by
- 454
- References
- 117
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- gold
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- Loewen, G., Jayawickramarajah, J., Zhuo, Y., & Shan, B. (2014). Functions of lncRNA HOTAIR in lung cancer. Journal of Hematology & Oncology. https://doi.org/10.1186/s13045-014-0090-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
