The DOI matches its Crossref record; 92 of the 92 references it cites were found in a registry or an index.
New development in CAR-T cell therapy
Open accessAbstract
Chimeric antigen receptor (CAR)-engineered T cells (CAR-T cells) have yielded unprecedented efficacy in B cell malignancies, most remarkably in anti-CD19 CAR-T cells for B cell acute lymphoblastic leukemia (B-ALL) with up to a 90% complete remission rate. However, tumor antigen escape has emerged as a main challenge for the long-term disease control of this promising immunotherapy in B cell malignancies. In addition, this success has encountered significant hurdles in translation to solid tumors, and the safety of the on-target/off-tumor recognition of normal tissues is one of the main reasons. In this mini-review, we characterize some of the mechanisms for antigen loss relapse and new strategies to address this issue. In addition, we discuss some novel CAR designs that are being considered to enhance the safety of CAR-T cell therapy in solid tumors.
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Li, X., Liu, R., Su, X., Pan, Y., Han, X., Shao, C., & Shi, Y. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1102-3 · Cited by 364
Perna, F., Berman, S. H., Soni, R. K., Mansilla-Soto, J., Eyquem, J., Hamieh, M., Hendrickson, R. C., Brennan, C. W., & Sadelain, M. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.09.004 · Cited by 346
Metadata
- Authors
- Wang, Z., Wu, Z., Liu, Y., & Han, W.
- Venue
- Journal of Hematology & Oncology
- Published
- 2017-02-21
- Volume
- 10
- Issue
- 1
- Pages
- 53-53
- ISSN
- 1756-8722 (ISSN-L)
- OpenAlex
- W2590004183
- Cited by
- 396
- References
- 92
- FWCI
- 16.37
- Type
- journal article
- Language
- en
- Open access
- gold
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