Stem cells, cancer, and cancer stem cells
Open accessAbstract
Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine. Perhaps the most important and useful property of stem cells is that of self-renewal. Through this property, striking parallels can be found between stem cells and cancer cells: tumours may often originate from the transformation of normal stem cells, similar signalling pathways may regulate self-renewal in stem cells and cancer cells, and cancer cells may include 'cancer stem cells' - rare cells with indefinite potential for self-renewal that drive tumorigenesis.
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Cancer is a genetic disorder.
“In the end, cancer is a genetic disorder [88,89].”
From The Tumor-on-Chip: Recent Advances in the Development of Microfluidic Systems to Recapitulate the Physiology of Solid Tumors (2019) · cites this paper as [89]
Mesenchymal stromal cells and cancer cells are thought to use similar signaling pathways regulating self-renewal and differentiation, namely the Wnt/β-catenin, Notch, Shh and BMP pathways.
“MSCs and cancer cells are thought to use similar signaling pathways regulating self-renewal and differentiation, namely the Wnt/β-catenin, Notch, Shh and BMP pathways [23], [54].”
From Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice (2019) · cites this paper as [54]
If the first mutation acquired leads to clonal expansion without malignant transformation, it should be possible to identify a pre-malignant stage in which only the initiating lesion is present.
“If the first mutation to be acquired leads to clonal expansion without malignant transformation, it should be possible to identify a pre-malignant stage in which only the initiating lesion is present 21.”
From Clonal hematopoiesis in human aging and disease (2019) · cites this paper as [21]
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- Authors
- Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L.
- Affiliations
- Duke University (US)
- Howard Hughes Medical Institute (US)
- University of Michigan (US)
- Stanford Medicine (US)
- Corresponding author
- Weissman, Irving L.
- Venue
- Nature
- Published
- 2001-11
- Volume
- 414
- Issue
- 6859
- Pages
- 105-111
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2102085111
- Cited by
- 9,738
- References
- 3
- Citations by year
- 2026: 90 · 2025: 179 · 2024: 261 · 2023: 344 · 2022: 338 · 2021: 422 · 2020: 421 · 2019: 454 · 2018: 441 · 2017: 552 · 2016: 544 · 2015: 647 · 2014: 630 · 2013: 648 · 2012: 650
- FWCI
- 10.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Keywords
- stem cells, cancer stem cells, self-renewal, hematopoietic stem cells, adult stem cells, progenitor cells, carcinogenesis, signaling pathways, regenerative medicine
- MeSH terms
- Animals, Cell Division, Cell Transformation, Neoplastic, Hematopoietic Stem Cells, Humans, Leukemia, Mutation, Neoplasms, Regeneration, Stem Cells, Signal Transduction
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