The DOI matches its Crossref record; 162 of the 162 references it cites were found in a registry or an index.
Current status and perspectives of patient-derived xenograft models in cancer research
Open accessAbstract
Cancers remain a major public health problem worldwide, which still require profound research in both the basic and preclinical fields. Patient-derived xenograft (PDX) models are created when cancerous cells or tissues from patients' primary tumors are implanted into immunodeficient mice to simulate human tumor biology in vivo, which have been extensively used in cancer research. The routes of implantation appeared to affect the outcome of PDX research, and there has been increasing applications of patient-derived orthotopic xenograft (PDOX) models. In this review, we firstly summarize the methodology to establish PDX models and then go over recent application and function of PDX models in basic cancer research on the areas of cancer characterization, initiation, proliferation, metastasis, and tumor microenvironment and in preclinical explorations of anti-cancer targets, drugs, and therapeutic strategies and finally give our perspectives on the future prospects of PDX models.
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1 retracted
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Immunogenic chemotherapy: Dose and schedule dependence and combination with immunotherapy
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A Beginner’s Guide to Cell Culture: Practical Advice for Preventing Needless Problems
Weiskirchen, S., Schröder, S. K., Buhl, E. M., & Weiskirchen, R. (2023) · Cells · doi:10.3390/cells12050682 · Cited by 148
Ng, S., Tan, W. J., Pek, M. M. X., Tan, M.-H., & Kurisawa, M. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119400 · Cited by 105
Wang, E., Xiang, K., Zhang, Y., & Wang, X.-F. (2022) · Journal of the National Cancer Center · doi:10.1016/j.jncc.2022.10.001 · Cited by 56
Metadata
- Authors
- Lai, Y., Wei, X., Lin, S., Qin, L., Cheng, L., & Li, P.
- Venue
- Journal of Hematology & Oncology
- Published
- 2017-05-12
- Volume
- 10
- Issue
- 1
- Pages
- 106-106
- ISSN
- 1756-8722 (ISSN-L)
- OpenAlex
- W2612901302
- Cited by
- 295
- References
- 162
- FWCI
- 13.36
- Type
- journal article
- Language
- en
- Open access
- gold
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- Lai, Y., Wei, X., Lin, S., Qin, L., Cheng, L., & Li, P. (2017). Current status and perspectives of patient-derived xenograft models in cancer research. Journal of Hematology & Oncology. https://doi.org/10.1186/s13045-017-0470-7
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
