The DOI matches its Crossref record; 119 of the 119 references it cites were found in a registry or an index.
m6A-binding proteins: the emerging crucial performers in epigenetics
Open accessAbstract
N 6-methyladenosine (m 6 A) is a well-known post-transcriptional modification that is the most common type of methylation in eukaryotic mRNAs. The regulation of m 6 A is dynamic and reversible, which is erected by m 6 A methyltransferases (“writers”) and removed by m 6 A demethylases (“erasers”). Notably, the effects on targeted mRNAs resulted by m 6 A predominantly depend on the functions of different m 6 A-binding proteins (“readers”) including YT521-B homology (YTH) domain family, heterogeneous nuclear ribonucleoproteins (HNRNPs), and insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs). Indeed, m 6 A readers not only participate in multiple procedures of RNA metabolism, but also are involved in a variety of biological processes. In this review, we summarized the specific functions and underlying mechanisms of m 6 A-binding proteins in tumorigenesis, hematopoiesis, virus replication, immune response, and adipogenesis.
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2 retracted
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Neoantigens in cancer immunotherapy
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N6-methyladenosine-dependent regulation of messenger RNA stability
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Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons
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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
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BackgroundInfluentialTumor Metastasis: Molecular Insights and Evolving Paradigms
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ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
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Cited by
Role of m6A RNA methylation in cardiovascular disease (Review)
Qin, Y., Li, L., Luo, E., Hou, J., Yan, G., Wang, D., Qiao, Y., & Tang, C. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4746 · Cited by 328
Chen, Y., Zhao, Y., Chen, J., Peng, C., Zhang, Y., Tong, R., Cheng, Q., Yang, B., Feng, X., Lu, Y., et al. (2020) · Molecular Cancer · doi:10.1186/s12943-020-01239-w · Cited by 284
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Metadata
- Authors
- Zhao, Y., Shi, Y., Shen, H., & Xie, W.
- Venue
- Journal of Hematology & Oncology
- Published
- 2020-04-10
- Volume
- 13
- Issue
- 1
- Pages
- 35-35
- ISSN
- 1756-8722 (ISSN-L)
- OpenAlex
- W3015493900
- Cited by
- 316
- References
- 119
- FWCI
- 12.86
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zhao, Y., Shi, Y., Shen, H., & Xie, W. (2020). m6A-binding proteins: the emerging crucial performers in epigenetics. Journal of Hematology & Oncology. https://doi.org/10.1186/s13045-020-00872-8
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