The DOI matches its Crossref record; 282 of the 282 references it cites were found in a registry or an index.
The MAPK and AMPK signalings: interplay and implication in targeted cancer therapy
Open accessAbstract
Cancer is characterized as a complex disease caused by coordinated alterations of multiple signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined pathways in cancer biology, and its hyperactivation is responsible for over 40% human cancer cases. To drive carcinogenesis, this signaling promotes cellular overgrowth by turning on proliferative genes, and simultaneously enables cells to overcome metabolic stress by inhibiting AMPK signaling, a key singular node of cellular metabolism. Recent studies have shown that AMPK signaling can also reversibly regulate hyperactive MAPK signaling in cancer cells by phosphorylating its key components, RAF/KSR family kinases, which affects not only carcinogenesis but also the outcomes of targeted cancer therapies against the MAPK signaling. In this review, we will summarize the current proceedings of how MAPK-AMPK signalings interplay with each other in cancer biology, as well as its implications in clinic cancer treatment with MAPK inhibition and AMPK modulators, and discuss the exploitation of combinatory therapies targeting both MAPK and AMPK as a novel therapeutic intervention.
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1 retracted
Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function
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Regulation of PD-L1 expression in the tumor microenvironment
Yi, M., Niu, M., Xu, L., Luo, S., & Wu, K. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-01027-5 · Cited by 681
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MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma
Moon, H., & Ro, S. W. (2021) · Cancers · doi:10.3390/cancers13123026 · Cited by 326
Ren, X., Li, Y., Zhou, Y., Hu, W., Yang, C., Jing, Q., Zhou, C., Wang, X., Hu, J., Wang, L., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102122 · Cited by 313
Self-citation
Metadata
- Authors
- Yuan, J., Dong, X., Yap, J., & Hu, J.
- Venue
- Journal of Hematology & Oncology
- Published
- 2020-08-17
- Volume
- 13
- Issue
- 1
- Pages
- 113-113
- ISSN
- 1756-8722 (ISSN-L)
- OpenAlex
- W3049642946
- Cited by
- 493
- References
- 282
- FWCI
- 15.84
- Type
- journal article
- Language
- en
- Open access
- gold
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