The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Targeting CD47 for cancer immunotherapy
Open accessAbstract
Much progress has been made in targeting CD47 for cancer immunotherapy in solid tumors (ST) and hematological malignancies. We summarized the CD47-related clinical research and analyzed the research trend both in the USA and in China. As of August 28, 2021, there are a total 23 related therapeutic agents with 46 clinical trials in the NCT registry platform. Among these trials, 29 are in ST, 14 in hematological malignancies and 3 in both solid tumor and hematological malignancy. The ST include gastric cancer, head and neck squamous cell carcinoma and leiomyosarcoma, while the hematological malignancies include non-Hodgkin's lymphoma, acute myeloid leukemia, myelodysplastic syndrome, multiple myeloma and chronic myeloid leukemia. Majority of the CD47-related clinical trials are at the early phases, such as 31 at phase I, 14 at phase II and 1 at phase III in the USA and 9, 6, 1, in China, respectively. The targets and spectrums of mechanism of action include 26 with mono-specific and 20 with bi-specific targets in the USA and 13 with mono-specific and 3 with bi-specific targets in China. The new generation CD47 antibodies have demonstrated promising results, and it is highly hopeful that some candidate agents will emerge and make into clinical application to meet the urgent needs of patients.
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Cites
Regulation and Function of the PD-L1 Checkpoint
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CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis
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CD47 Blockade by Hu5F9-G4 and Rituximab in Non-Hodgkin’s Lymphoma
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The CD47-SIRPα Immune Checkpoint
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CD47-blocking antibodies restore phagocytosis and prevent atherosclerosis
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Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential
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Cited by
Lu, Q., Yang, D., Li, H., Zhu, Z., Zhang, Z., Chen, Y., Yang, N., Li, J., Wang, Z., Niu, T., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216660 · Cited by 15
Zhou, E., Xing, Z., Wang, M., Lu, D., Hao, M., Tang, G., Li, S., Chen, Y., Zhang, W., Li, X., et al. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118198
Metadata
- Authors
- Jiang, Z., Sun, H., Yu, J., Tian, W., & Song, Y.
- Venue
- Journal of Hematology & Oncology
- Published
- 2021-10-30
- Volume
- 14
- Issue
- 1
- Pages
- 180-180
- ISSN
- 1756-8722 (ISSN-L)
- OpenAlex
- W3210890261
- Cited by
- 346
- References
- 75
- FWCI
- 18.30
- Type
- journal article
- Language
- en
- Open access
- gold
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