Delivery of CD47-SIRPα checkpoint blocker by BCMA-directed UCAR-T cells enhances antitumor efficacy in multiple myeloma
Abstract
In the treatment of relapsed or refractory multiple myeloma patients, BCMA-directed autologous CAR-T cells have showed excellent anti-tumor activity. However, their widespread application is limited due to the arguably cost and time-consuming. Multiple myeloma cells highly expressed CD47 molecule and interact with the SIRPα ligand on the surface of macrophages, in which evade the clearance of macrophages through the activation of "don't eat me" signal. In this study, a BCMA-directed universal CAR-T cells, BC404-UCART, secreting a CD47-SIRPα blocker was developed using CRISPR/Cas9 gene-editing system. BC404-UCART cells significantly inhibited tumor growth and prolonged the survival of mice in the xenograft model. The anti-tumor activity of BC404-UCART cells was achieved via two mechanisms, on the one hand, the UCAR-T cells directly killed tumor cells, on the other hand, the BC404-UCART cells enhanced the phagocytosis of macrophages by secreting anti-CD47 nanobody hu404-hfc fusion that blocked the "don't eat me" signal between macrophages and tumor cells, which provides a potential strategy for the development of novel "off-the-shelf" cellular immunotherapies for the treatment of multiple myeloma.
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BC404-UCART cells were shown to significantly inhibit the growth of MM tumor cells and prolong the survival of mice in a xenograft model.
“BC404-UCART cells were shown to significantly inhibit the growth of MM tumor cells and prolong the survival of mice in a xenograft model.”
From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [265]
The use of a CD47-SIRPα blocker may enhance the efficacy of CAR-T cell therapy by overcoming immune evasion mechanisms employed by tumor cells.
“The use of a CD47-SIRPα blocker may enhance the efficacy of CAR-T cell therapy by overcoming immune evasion mechanisms employed by tumor cells [265].”
From Multiple myeloma: signaling pathways and targeted therapy (2024) · cites this paper as [265]
Cites
Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection
Eyquem, J., Mansilla-Soto, J., Giavridis, T., van der Stegen, S. J. C., Hamieh, M., Cunanan, K. M., Odak, A., Gönen, M., & Sadelain, M. (2017) · Nature · doi:10.1038/nature21405 · Cited by 1,831 · see citing works
Shultz, L. D., Lyons, B. L., Burzenski, L. M., Gott, B., Chen, X., Chaleff, S., Kotb, M., Gillies, S. D., King, M., Mangada, J., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6477 · Cited by 1,736 · see citing works
Daratumumab, Bortezomib, and Dexamethasone for Multiple Myeloma
Palumbo, A., Chanan-Khan, A., Weisel, K., Nooka, A. K., Masszi, T., Beksac, M., Spicka, I., Hungria, V., Munder, M., Mateos, M. V., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1606038 · Cited by 1,522 · see citing works
Bruhns, P., Iannascoli, B., England, P., Mancardi, D. A., Fernandez, N., Jorieux, S., & Daëron, M. (2009) · Blood · doi:10.1182/blood-2008-09-179754 · Cited by 1,479 · see citing works
‘Off-the-shelf’ allogeneic CAR T cells: development and challenges
Depil, S., Duchateau, P. N., Grupp, S. A., Mufti, G. J., & Poirot, L. (2020) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0051-2 · Cited by 1,238 · see citing works
Kumar, S. K., Rajkumar, S. V., Kyle, R. A., van Duin, M., Sonneveld, P., Mateos, M., Gay, F., & Anderson, K. C. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.46 · Cited by 1,235 · see citing works
Diagnosis and Management of Multiple Myeloma
Cowan, A. J., Green, D. J., Kwok, M., Lee, S., Coffey, D. G., Holmberg, L., Tuazon, S. A., Gopal, A. K., & Libby, E. N. (2022) · JAMA · doi:10.1001/jama.2022.0003 · Cited by 1,054 · see citing works
Divergent Immunoglobulin G Subclass Activity Through Selective Fc Receptor Binding
Nimmerjahn, F., & Ravetch, J. V. (2005) · Science · doi:10.1126/science.1118948 · Cited by 1,040 · see citing works
Multiplex genome editing to generate universal CAR T cells resistant to PD1 inhibition
Ren, J., Liu, X., Fang, C., Jiang, S., June, C. H., & Zhao, Y. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-1300 · Cited by 942 · see citing works
Phagocytosis checkpoints as new targets for cancer immunotherapy
Feng, M., Jiang, W., Kim, B. Y. S., Zhang, C. C., Fu, Y., & Weissman, I. L. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-019-0183-z · Cited by 914 · see citing works
Kyle, R. A., & Rajkumar, S. V. (2008) · Blood · doi:10.1182/blood-2007-10-078022 · Cited by 857 · see citing works
CD47 blockade triggers T cell–mediated destruction of immunogenic tumors
Liu, X., Pu, Y., Cron, K. R., Deng, L., Kline, J. P., Frazier, W. A., Xu, H., Peng, H., Fu, Y., & Xu, M. M. (2015) · Nature Medicine · doi:10.1038/nm.3931 · Cited by 770 · see citing works
The CD47-SIRPα Immune Checkpoint
Logtenberg, M. E. W., Scheeren, F. A., & Schumacher, T. N. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.011 · Cited by 750 · see citing works
Vincke, C., Loris, R., Saerens, D., Martínez‐Rodríguez, S., Muyldermans, S., & Conrath, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806889200 · Cited by 577 · see citing works
The CD47‐SIRPα signaling axis as an innate immune checkpoint in cancer
Matlung, H. L., Szilagyi, K., Barclay, N., & van den Berg, T. K. (2017) · Immunological Reviews · doi:10.1111/imr.12527 · Cited by 563 · see citing works
Shah, N., Chari, A., Scott, E., Mezzi, K., & Usmani, S. Z. (2020) · Leukemia · doi:10.1038/s41375-020-0734-z · Cited by 490 · see citing works
CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer
Weiskopf, K., Jahchan, N. S., Schnorr, P. J., Cristea, S., Ring, A. M., Maute, R. L., Volkmer, A. K., Volkmer, J.-P., Liu, J., Lim, J. S., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci81603 · Cited by 441 · see citing works
Self-citationCRISPR-Cas9-mediated multiplex gene editing in CAR-T cells
Liu, X., Zhang, Y., Cheng, C., Cheng, A. W., Zhang, X., Li, N., Xia, C., Wei, X., Liu, X., & Wang, H. (2016) · Cell Research · doi:10.1038/cr.2016.142 · Cited by 396 · see citing works
A versatile system for rapid multiplex genome-edited CAR T cell generation
Ren, J., Zhang, X., Liu, X., Fang, C., Jiang, S., June, C. H., & Zhao, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.15218 · Cited by 395 · see citing works
King, M. A., Covassin, L., Brehm, M. A., Racki, W. J., Pearson, T., Leif, J., Laning, J. C., Fodor, W. L., Foreman, O., Burzenski, L. M., et al. (2009) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2009.03933.x · Cited by 389 · see citing works
Shultz, L. D., Saito, Y., Najima, Y., Tanaka, S., Ochi, T., Tomizawa, M., Doi, T., Sone, A., Suzuki, N., Fujiwara, H., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000475107 · Cited by 366 · see citing works
Tai, Y., Acharya, C., An, G., Moschetta, M., Zhong, M. Y., Feng, X., Cea, M., Cagnetta, A., Wen, K., van Eenennaam, H., et al. (2016) · Blood · doi:10.1182/blood-2016-01-691162 · Cited by 352 · see citing works
Targeting CD47 for cancer immunotherapy
Jiang, Z., Sun, H., Yu, J., Tian, W., & Song, Y. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01197-w · Cited by 349 · see citing works
The proteasome and proteasome inhibitors in multiple myeloma
Gandolfi, S., Laubach, J. P., Hideshima, T., Chauhan, D., Anderson, K. C., & Richardson, P. G. G. (2017) · Cancer and Metastasis Reviews · doi:10.1007/s10555-017-9707-8 · Cited by 342 · see citing works
Universal CARs, universal T cells, and universal CAR T cells
Zhao, J., Lin, Q., Song, Y., & Liu, D. (2018) · Journal of Hematology & Oncology · doi:10.1186/s13045-018-0677-2 · Cited by 315 · see citing works
Fricker, L. D. (2020) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010919-023603 · Cited by 309 · see citing works
Chim, C. S., Kumar, S. K., Orlowski, R. Z., Cook, G., Richardson, P. G., Gertz, M. A., Giralt, S., Mateos, M. V., Leleu, X., & Anderson, K. C. (2018) · Leukemia · doi:10.1038/leu.2017.329 · Cited by 305 · see citing works
Hu, Y., Zhou, Y., Zhang, M., Ge, W., Li, Y., Yang, L., Wei, G., Han, L., Wang, H., Yu, S., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-3863 · Cited by 287 · see citing works
Self-citationAffinity of human IgG subclasses to mouse Fc gamma receptors
Dekkers, G., Bentlage, A. E. H., Stegmann, T. C., Howie, H. L., Lissenberg‐Thunnissen, S. N., Zimring, J. C., Rispens, T., & Vidarsson, G. (2017) · mAbs · doi:10.1080/19420862.2017.1323159 · Cited by 281 · see citing works
Immunomodulatory Drugs in Multiple Myeloma: Mechanisms of Action and Clinical Experience
Holstein, S. A., & McCarthy, P. L. (2017) · Drugs · doi:10.1007/s40265-017-0689-1 · Cited by 258 · see citing works
Mailankody, S., Matous, J. V., Chhabra, S., Liedtke, M., Sidana, S., Oluwole, O. O., Malik, S., Nath, R., Anwer, F., Cruz, J. C., et al. (2023) · Nature Medicine · doi:10.1038/s41591-022-02182-7 · Cited by 257 · see citing works
Anti-CD47 antibodies promote phagocytosis and inhibit the growth of human myeloma cells
Kim, D., Wang, J., Willingham, S. B., Martin, R. K., Wernig, G., & Weissman, I. L. (2012) · Leukemia · doi:10.1038/leu.2012.141 · Cited by 249 · see citing works
Crosstalk between Human IgG Isotypes and Murine Effector Cells
Overdijk, M. B., Verploegen, S. A. B. W., Buijsse, A. O., Vink, T., Leusen, J. H. W., Bleeker, W. K., & Parren, P. W. H. I. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200356 · Cited by 224 · see citing works
CD47/SIRPα pathway mediates cancer immune escape and immunotherapy
Jia, X., Yan, B., Tian, X., Liu, Q., Jin, J., Shi, J., & Hou, Y. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.60782 · Cited by 205 · see citing works
Steplewski, Z., Sun, L. K., Shearman, C. W., Ghrayeb, J., Daddona, P. E., & Koprowski, H. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.13.4852 · Cited by 204 · see citing works
Kagoya, Y., Guo, T., Yeung, B., Saso, K., Anczurowski, M., Wang, C.-H., Murata, K., Sugata, K., Saijo, H., Matsunaga, Y., et al. (2020) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0508 · Cited by 179 · see citing works
Ottaviano, G., Georgiadis, C., Gkazi, S. A., Syed, F., Zhan, H., Etuk, A., Preece, R., Chu, J., Kubat, A., Adams, S., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abq3010 · Cited by 175 · see citing works
Wang, S., Wu, Q., Chen, T., Su, R., Pan, C., Qian, J., Huang, H., Yin, S., Xie, H., Zhou, L., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.03.011 · Cited by 167 · see citing works
Daratumumab in multiple myeloma
Nooka, A. K., Kaufman, J. L., Hofmeister, C. C., Joseph, N. S., Heffner, T. L., Gupta, V. A., Sullivan, H. C., Neish, A. S., Dhodapkar, M. V., & Lonial, S. (2019) · Cancer · doi:10.1002/cncr.32065 · Cited by 166 · see citing works
Emerging immunotherapies in multiple myeloma
Shah, U. A., & Mailankody, S. (2020) · BMJ · doi:10.1136/bmj.m3176 · Cited by 157 · see citing works
Hu, T., Liu, H., Liang, Z., Wang, F., Zhou, C., Zheng, X., Zhang, Y., Song, Y., Hu, J., He, X., et al. (2020) · Theranostics · doi:10.7150/thno.40860 · Cited by 156 · see citing works
Belantamab Mafodotin: First Approval
Markham, A. (2020) · Drugs · doi:10.1007/s40265-020-01404-x · Cited by 145 · see citing works
Allogeneic CAR Cell Therapy—More Than a Pipe Dream
Caldwell, K. J., Gottschalk, S. M., & Talleur, A. C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.618427 · Cited by 133 · see citing works
Xu, B., Tian, L., Chen, J., Wang, J., Ma, R., Dong, W., Li, A., Zhang, J., Chiocca, E. A., Kaur, B., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26003-6 · Cited by 110 · see citing works
Du, K., Li, Y., Liu, J., Chen, W., Wei, Z., Luo, Y., Liu, H., Qi, Y., Wang, F., & Sui, J. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.01.006 · Cited by 107 · see citing works
Xie, Y. J., Dougan, M. L., Ingram, J. R., Pishesha, N., Fang, T., Momin, N., & Ploegh, H. L. (2020) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-19-0734 · Cited by 99 · see citing works
Kwong, L. S., Brown, M. H., Barclay, A. N., & Hatherley, D. (2014) · Immunology · doi:10.1111/imm.12290 · Cited by 96 · see citing works
Yu, L., Ding, Y., Wan, T., Deng, T., Huang, H., & Liu, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.768115 · Cited by 95 · see citing works
Kang, C. (2022) · Drugs · doi:10.1007/s40265-022-01793-1 · Cited by 92 · see citing works
Lu, Q., Zhang, Z., Li, H., Zhong, K., Zhao, Q., Wang, Z., Wu, Z., Yang, D., Sun, S., Yang, N., et al. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00768-w · Cited by 89 · see citing works
Self-citationTargeting CD47 as a Novel Immunotherapy for Multiple Myeloma
Sun, J., Muz, B., Alhallak, K., Markovic, M., Gurley, S., Wang, Z., Guenthner, N., Wasden, K., Fiala, M. A., King, J. A., et al. (2020) · Cancers · doi:10.3390/cancers12020305 · Cited by 86 · see citing works
Self-citationSheng, Y., Wang, K., Lu, Q., Ji, P., Liu, B., Zhu, J., Liu, Q., Sun, Y., Zhang, J., Zhou, E., et al. (2019) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0468-0 · Cited by 81 · see citing works
Self-citationFDA approves first BCMA-targeted CAR-T cell therapy
Mullard, A. (2021) · Nature Reviews Drug Discovery · doi:10.1038/d41573-021-00063-1 · Cited by 81 · see citing works
Dhillon, S. (2020) · Drugs · doi:10.1007/s40265-020-01311-1 · Cited by 79 · see citing works
Tipanee, J., Samara-Kuko, E., Gevaert, T., Chuah, M. K., & VandenDriessche, T. (2022) · Molecular Therapy · doi:10.1016/j.ymthe.2022.06.006 · Cited by 76 · see citing works
FDA approves second BCMA-targeted CAR-T cell therapy
Mullard, A. (2022) · Nature Reviews Drug Discovery · doi:10.1038/d41573-022-00048-8 · Cited by 68 · see citing works
Tian, L., Xu, B., Teng, K.-Y., Song, M., Zhu, Z., Chen, Y., Wang, J., Zhang, J., Feng, M., Kaur, B., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-21-1248 · Cited by 66 · see citing works
Self-citationRastgoo, N., Wu, J., Liu, M., Pourabdollah, M., Atenafu, E. G., Reece, D. E., Chen, W., & Chang, H. (2019) · Haematologica · doi:10.3324/haematol.2019.227579 · Cited by 62 · see citing works
Delivery of CD47 blocker SIRPα-Fc by CAR-T cells enhances antitumor efficacy
Chen, H., Yang, Y., Deng, Y., Wei, F., Zhao, Q., Liu, Y., Liu, Z., Yu, B., & Huang, Z. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003737 · Cited by 61 · see citing works
Cao, X., Wang, Y., Zhang, W., Zhong, X., Gunes, E. G., Dang, J., Wang, J., Epstein, A. L., Querfeld, C., Sun, Z., et al. (2022) · Blood · doi:10.1182/blood.2021013901 · Cited by 59 · see citing works
Yu, J., Li, S., Chen, D., Liu, D., Guo, H., Yang, C., Zhang, W., Zhang, L., Zhao, G., Tu, X., et al. (2022) · Journal of Hematology & Oncology · doi:10.1186/s13045-022-01385-2 · Cited by 55 · see citing works
Gupta, M., Dillon, S. R., Ziesmer, S. C., Feldman, A. L., Witzig, T. E., Ansell, S. M., Cerhan, J. R., & Novak, A. J. (2009) · Blood · doi:10.1182/blood-2008-09-179762 · Cited by 52 · see citing works
Wang, R., Zhang, C., Cao, Y., Wang, J., Jiao, S., Zhang, J., Wang, M., Tang, P., Ouyang, Z., Liang, W., et al. (2022) · Theranostics · doi:10.7150/thno.79367 · Cited by 49 · see citing works
Keam, S. J. (2023) · Drugs · doi:10.1007/s40265-023-01945-x · Cited by 48 · see citing works
Lu, Q., Li, X., Zhao, J., Zhu, J.-H., Luo, Y., Duan, H. Q., Ji, P., Wang, K., Liu, B., Wang, X., et al. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-019-0568-x · Cited by 47 · see citing works
Self-citationDhillon, S. (2023) · Drugs · doi:10.1007/s40265-023-01954-w · Cited by 47 · see citing works
Dacek, M. M., Kurtz, K. G., Wallisch, P., Pierre, S. A., Khayat, S., Bourne, C. M., Gardner, T. J., Vogt, K. C., Aquino, N., Younes, A., et al. (2023) · Blood · doi:10.1182/blood.2022016101 · Cited by 45 · see citing works
Sanchez, E., Smith, E. J., Yashar, M. A., Patil, S., Li, M., Porter, A. L., Tanenbaum, E. J., Schlossberg, R. E., Soof, C. M., Hekmati, T., et al. (2017) · Targeted Oncology · doi:10.1007/s11523-017-0538-x · Cited by 43 · see citing works
Elotuzumab: First Global Approval
Markham, A. (2016) · Drugs · doi:10.1007/s40265-016-0540-0 · Cited by 34 · see citing works
Søndergaard, H., Kvist, P. H., & Haase, C. (2012) · Clinical & Experimental Immunology · doi:10.1111/cei.12051 · Cited by 33 · see citing works
Engineering primary T cells with chimeric antigen receptors for rewired responses to soluble ligands
Chang, Z., Hou, A. J., & Chen, Y. Y. (2020) · Nature Protocols · doi:10.1038/s41596-020-0294-8 · Cited by 25 · see citing works
Self-citationPaul, B. A., Liedtke, M., Khouri, J., Rifkin, R. M., Gandhi, M. D., Kin, A. D., Levy, M. Y., Silbermann, R. W., Cottini, F., Sborov, D. W., et al. (2023) · Future Oncology · doi:10.2217/fon-2022-0975 · Cited by 20 · see citing works
Wilson, W. C., Richards, J. O., Puro, R. J., Andrejeva, G., Capoccia, B. J., Donio, M. J., Hiebsch, R. R., Chakraborty, P., Sung, V., & Pereira, D. S. (2020) · Blood · doi:10.1182/blood-2020-139655 · Cited by 20 · see citing works
Patel, K., Orlowski, R. Z., Doucette, K., Maris, M. B., Pianko, M. J., Ramchandren, R., Stevens, D. A., Vesole, D. H., Uger, R. A., Scheuber, A., et al. (2022) · Journal of Clinical Oncology · doi:10.1200/jco.2022.40.16_suppl.tps8071 · Cited by 9 · see citing works
Flagged first, then by citations
1 of the 75 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Multiple myeloma: signaling pathways and targeted therapy
Lu, Q., Yang, D., Li, H., Niu, T., & Tong, A. (2024) · Molecular biomedicine · doi:10.1186/s43556-024-00188-w · Cited by 90 · see citing works
Self-citationMartins, T. A., Kaymak, D., Tatari, N., Gerster, F., Hogan, S., Ritz, M.-F., Sabatino, V., Wieboldt, R., Bartoszek, E. M., McDaid, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-54129-w · Cited by 54 · see citing works
Jiang, C., Sun, H., Jiang, Z., Tian, W., Cang, S., & Yu, J. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1378647 · Cited by 47 · see citing works
Recent advances in universal chimeric antigen receptor T cell therapy
Jiang, N., Yang, Z., Miao, H., Xing, S., Wang, S., & Li, N. (2025) · Journal of Hematology & Oncology · doi:10.1186/s13045-025-01737-8 · Cited by 39 · see citing works
The burden of multiple myeloma in China: Trends from 1990 to 2021 and forecasts for 2050
Dou, X., Duan, G., Zhong, Y., Liu, Y., Peng, N., Lei, W., Qi, J., Zhou, M., Zhang, X., & Lu, J. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217440 · Cited by 34 · see citing works
The mechanisms and countermeasures for CAR-T cell expansion and persistence deficiency
Bao, Y.-T., Lv, M., Huang, X., & Zhao, X. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217771 · Cited by 11 · see citing works
CAR-T Therapy in Multiple Myeloma: Looking Beyond
Maiorana, G., Antolino, G., Verde, G. L., & Tafuri, A. (2024) · Hemato · doi:10.3390/hemato5020015 · Cited by 4 · see citing works
Blood cancer therapy with synthetic receptors and CRISPR technology
Zhang, H., Zhong, M., Zhang, J., & Chen, C. (2025) · Leukemia Research · doi:10.1016/j.leukres.2025.107646 · Cited by 4 · see citing works
Zhou, Y., Zou, Y., Lv, S., Tan, D., Li, G., Fu, W., Lei, C., Lu, M., & Hu, S. (2025) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2025.101417 · Cited by 3 · see citing works
Li, H., Lu, Q., Yu, Z., Wu, Z., Zhu, Z., Li, J., Zhang, Z., Wang, Z., Yang, N., Chen, Y., et al. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003588 · Cited by 3 · see citing works
Self-citationStrategies and mechanisms for the enhancement of chimeric antigen receptor T-cell functions
Han, S. Z., Yue, J., Zheng, H., Huang, Y., Kong, D., Wei, G., Hu, Y., & Huang, H. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3061-8 · Cited by 2 · see citing works
Osborne, M., & Maher, J. F. (2025) · Biology · doi:10.3390/biology14121790 · Cited by 1 · see citing works
Zhang, H., Li, W., Xiao, P., Lu, Z., Tian, Y., & Xu, Y. (2026) · The Journal of Pathology · doi:10.1002/path.70031 · Cited by 1 · see citing works
CAR-T and nanotechnology: A comparative Perspective on autoimmune disease and cancer
Pavithra, A. J., & Ragavendran, C. (2025) · Advances in Biomarker Sciences and Technology · doi:10.1016/j.abst.2025.03.002 · Cited by 1 · see citing works
Innate immune dysregulation in multiple myeloma: molecular basis and mechanistic interventions
Wang, G., Gao, H., Xie, T., & Zi, F. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116996
- Authors
- Lu, Q., Yang, D., Li, H., Zhu, Z., Zhang, Z., Chen, Y., Yang, N., Li, J., Wang, Z., Niu, T., & Tong, A.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Northwest A&F University (CN)
- Sichuan University (CN)
- Corresponding author
- Niu, Ting
- Tong, Aiping
- ORCID
- Venue
- Cancer Letters
- Publisher
- Elsevier BV
- Published
- 2024-03
- Volume
- 585
- Pages
- 216660
- ISSN
- 0304-3835 (ISSN-L)
- OpenAlex
- W4391116732
- Cited by
- 15
- References
- 75
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 4
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Cancer Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Oncology › CAR-T cell therapy research
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Keywords
- multiple myeloma, BCMA, universal CAR-T cells, off-the-shelf CAR-T, macrophage phagocytosis, don't eat me signal, CRISPR/Cas9 genome editing, autologous CAR T cells, relapsed/refractory multiple myeloma
- MeSH terms
- Animals, Antigens, Differentiation, Humans, Multiple Myeloma, Neoplasms, Phagocytosis, Receptors, Immunologic, T-Lymphocytes, Mice, CD47 Antigen, B-Cell Maturation Antigen
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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