The DOI matches its Crossref record; 192 of the 192 references it cites were found in a registry or an index.
Metabolism, metabolites, and macrophages in cancer
Open accessAbstract
Tumour-associated macrophages (TAMs) are crucial components of the tumour microenvironment and play a significant role in tumour development and drug resistance by creating an immunosuppressive microenvironment. Macrophages are essential components of both the innate and adaptive immune systems and contribute to pathogen resistance and the regulation of organism homeostasis. Macrophage function and polarization are closely linked to altered metabolism. Generally, M1 macrophages rely primarily on aerobic glycolysis, whereas M2 macrophages depend on oxidative metabolism. Metabolic studies have revealed that the metabolic signature of TAMs and metabolites in the tumour microenvironment regulate the function and polarization of TAMs. However, the precise effects of metabolic reprogramming on tumours and TAMs remain incompletely understood. In this review, we discuss the impact of metabolic pathways on macrophage function and polarization as well as potential strategies for reprogramming macrophage metabolism in cancer treatment.
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Cites
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Cited by
Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
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Self-citation
Metadata
- Authors
- Li, M., Yang, Y., Xiong, L., Jiang, P., Wang, J., & Li, C.
- Venue
- Journal of Hematology & Oncology
- Published
- 2023-07-25
- Volume
- 16
- Issue
- 1
- Pages
- 80-80
- ISSN
- 1756-8722 (ISSN-L)
- OpenAlex
- W4385241089
- Cited by
- 507
- References
- 192
- FWCI
- 44.71
- Type
- journal article
- Language
- en
- Open access
- gold
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- Li, M., Yang, Y., Xiong, L., Jiang, P., Wang, J., & Li, C. (2023). Metabolism, metabolites, and macrophages in cancer. Journal of Hematology & Oncology. https://doi.org/10.1186/s13045-023-01478-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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