Body Fatness and Cancer — Viewpoint of the IARC Working Group
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The International Agency for Research on Cancer convened a workshop on the relationship between body fatness and cancer, from which an IARC handbook on the topic will appear. An executive summary of the evidence is presented.
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A large prospective analysis of more than 900,000 Americans found greater than a 50% increase in cancer mortality among patients with the highest body mass index.
“Many epidemiological studies report associations between obesity and cancer, and a large prospective analysis of more than 900,000 Americans found greater than a 50% increase in cancer mortality in patients with the highest body mass index (15, 16).”
From Metabolic reprogramming and cancer progression (2020) · cites this paper as [16]
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“that excess body fat is a major risk factor for many cancers, including esophageal, pancreatic, colorectal, postmenopausal breast , endometrial, renal, ovarian, gallbladder, hepatic and gastric cardia, among others[8].”
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- Authors
- Lauby-Secretan, B., Scoccianti, C., Loomis, D., Grosse, Y., Bianchini, F., & Straif, K.
- Affiliations
- German Cancer Research Center (DE)
- Venue
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Published
- 2016-08-25
- Volume
- 375
- Issue
- 8
- Pages
- 794-798
- ISSN
- 0028-4793 (ISSN-L)
- 1533-4406
- PMC
- PMC6754861
- OpenAlex
- W2510411424
- Cited by
- 3,596
- References
- 35
- Citations by year
- 2026: 342 · 2025: 398 · 2024: 456 · 2023: 448 · 2022: 435 · 2021: 454 · 2020: 365 · 2019: 297 · 2018: 226 · 2017: 143 · 2016: 26 · 2015: 1
- FWCI
- 123.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- New England Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion, other-oa)
- Middlesex University Research Repository (Middlesex University Of London) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Discovery Research Portal (University of Dundee) (submittedVersion, other-oa)
- Funders
- World Health Organization
- Deutsches Krebsforschungszentrum
- Centre International de Recherche sur le Cancer
- Cancer Research UK (17962)
- National Cancer Institute (R01CA189184, R01CA207371, U01CA206110)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- adiposity, obesity, cancer risk, cancer prevention, cancer epidemiology
- MeSH terms
- Adolescent, Adult, Child, Congresses as Topic, Disease Susceptibility, Female, Humans, Male, Neoplasms, Obesity, Risk Factors, Advisory Committees
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